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- W4313478237 abstract "Glucosylceramide (GlcCer) is composed of a glucose moiety attached to ceramides (Cer). GlcCer was reported to reduce the intestinal impairments in vivo and suppress in vitro intestinal inflammation. In this study, to clarify the effect of GlcCer on intestinal impairments in vivo, we compared the effects of shiitake mushroom-derived GlcCer (fungal GlcCer) on the formation of aberrant crypt foci (ACF) and colon inflammation with those of fungal Cer having the same Cer moiety of the fungal GlcCer. Fungal GlcCer- or Cer-supplemented diets significantly suppressed ACF formation in 1,2-dimethylhydrazine (DMH)-treated mice. Dietary fungal GlcCer reduced the expression of inflammation-related cytokines and apoptosis-related proteins induced by DMH, whereas dietary fungal Cer hardly reduced their expression upon intestinal injuries. Furthermore, when fungal GlcCer was ingested to the mice, only a small amount of fungal Cer was detected in the feces. These results indicate that the ingested fungal GlcCer might be hardly metabolized to fungal Cer and the GlcCer itself might suppress ACF formation in DMH-treated mice by suppressing intestinal inflammation." @default.
- W4313478237 created "2023-01-06" @default.
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- W4313478237 date "2023-01-02" @default.
- W4313478237 modified "2023-10-16" @default.
- W4313478237 title "Dietary Fungal Glucosylceramide and Ceramide Reduce the Formation of Aberrant Crypt Foci in 1,2-Dimethylhydrazine-Treated Mice: Differences in the Role of Glucosylceramide and Ceramide" @default.
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- W4313478237 doi "https://doi.org/10.1021/acsfoodscitech.2c00290" @default.
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