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- W4313478249 startingPage "172" @default.
- W4313478249 abstract "Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most common characteristics of cancer. Hypoxia shapes the landscape of the tumor microenvironment (TME) into a pro-tumorigenic and pro-metastatic niche through arrays of pathological alterations such as abnormal vasculature, altered metabolism, immune-suppressive phenotype, etc. In addition, emerging evidence suggests that limited efficacy or the development of resistance towards antitumor therapy may be largely due to the hypoxic TME. This review will focus on summarizing the knowledge about the molecular machinery that mediates the hypoxic cellular responses and adaptations, as well as highlighting the effects and consequences of hypoxia, especially for angiogenesis regulation, cellular metabolism alteration, and immunosuppressive response within the TME. We also outline the current advances in novel therapeutic implications through targeting hypoxia in TME. A deep understanding of the basics and the role of hypoxia in the tumor will help develop better therapeutic avenues in cancer treatment." @default.
- W4313478249 created "2023-01-06" @default.
- W4313478249 creator A5013743722 @default.
- W4313478249 creator A5025681399 @default.
- W4313478249 creator A5025851882 @default.
- W4313478249 creator A5075596275 @default.
- W4313478249 date "2023-01-01" @default.
- W4313478249 modified "2023-10-18" @default.
- W4313478249 title "Tumor hypoxia: From basic knowledge to therapeutic implications" @default.
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