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- W4313478359 abstract "PurposeTo identify the vascular biomarkers of peripheral capillary non-perfusion in patients affected by naïve central retinal vein occlusion (CRVO), and to analyze their changes over the follow-up.Study DesignConsecutive prospective case series with a planned follow-up of two years.Participants35 patients affected by CRVO and 35 healthy gender- and age-matched subjects were enrolled in the studyMethodsOphthalmologic examination included best corrected visual acuity (BCVA), ultra-widefield fluorescein angiography (UWFFA), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA).Main outcome measuresVessel density (VD) at the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were calculated on OCTA images. The ischemic index was calculated on UWFFA.ResultsThe mean baseline ischemic index was 37%, increasing to 40% at the end of the follow-up, whereas it was 4.9% in the patients’ fellow eyes, and 4.5% in the control group, with no change over the follow-up. OCTA revealed VD reduction in the DCP, considering both 3x3mm and 12x12mm scans. The correlation analyses revealed that DCP VD was the only parameter showing a statistically significant correlation with the foveal avascular zone area, BCVA, and ischemic index.ConclusionsDCP VD impairment is detectable in all CRVO cases, variably involving both the central retina (with enlarged foveal avascular zone) and the periphery (with VD reduction in the peripheral retina). The severity of DCP VD reduction has correlates with various clinical markers. DCP VD may represent a crucial biomarker to characterize CRVO, and further studies are necessary to identify the cutoff thresholds for the different clinical manifestations." @default.
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- W4313478359 date "2023-06-01" @default.
- W4313478359 modified "2023-10-14" @default.
- W4313478359 title "Deep Capillary Plexus as Biomarker of Peripheral Capillary Nonperfusion in Central Retinal Vein Occlusion" @default.
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- W4313478359 doi "https://doi.org/10.1016/j.xops.2022.100267" @default.
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