FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313478854> ?p ?o ?g. }

• W4313478854 endingPage "104138" @default.
• W4313478854 startingPage "104138" @default.
• W4313478854 abstract "A single-layer osmotic controlled-release tablet, also referred to as an extrudable core system (ECS) tablet, has been modelled to predict the drug release rate as function of various parameters related to the excipients and the active pharmaceutical ingredient, the geometry of the tablet and the coating thickness. The analysis leads to a better understanding of the drug release process resulting in a mathematical tool for design of new formulations. The model accounts for all the main events occurring during the drug release process from a tablet coated with a semi-permeable membrane, namely, the solvent influx driven by the difference in osmotic pressure across the coating, dispersion of core components (drug, polymer and osmogen), swelling of the tablet due to solvent accumulation, build-up of hydrostatic pressure inside the tablet, tensile stress acting on the coating, the extrusion of the dispersed core components and dissolution of drug particles outside the tablet in the bulk. We also derive the condition for successful entrainment of drug particles based on the viscosity of the hydrated phase and other parameters of the system. The model was validated by comparing the predictions with drug release data for two drugs of varying solubility. The agreement between the predicted release and the measurements confirmed the suitability of the model in describing the drug release process in the osmotic controlled-release tablet." @default.
• W4313478854 created "2023-01-06" @default.
• W4313478854 creator A5008702877 @default.
• W4313478854 creator A5016134338 @default.
• W4313478854 creator A5053069304 @default.
• W4313478854 creator A5069254991 @default.
• W4313478854 creator A5070593067 @default.
• W4313478854 creator A5085286170 @default.
• W4313478854 date "2023-02-01" @default.
• W4313478854 modified "2023-09-25" @default.
• W4313478854 title "A model to predict drug release from a single-layer osmotic controlled-release tablet" @default.
• W4313478854 cites W197368718 @default.
• W4313478854 cites W1986998634 @default.
• W4313478854 cites W1995687288 @default.
• W4313478854 cites W1998333711 @default.
• W4313478854 cites W2022066406 @default.
• W4313478854 cites W2024610761 @default.
• W4313478854 cites W2030951340 @default.
• W4313478854 cites W2032087356 @default.
• W4313478854 cites W2044643145 @default.
• W4313478854 cites W2046601630 @default.
• W4313478854 cites W2046627126 @default.
• W4313478854 cites W2057252013 @default.
• W4313478854 cites W2062374144 @default.
• W4313478854 cites W2062810479 @default.
• W4313478854 cites W2065993845 @default.
• W4313478854 cites W2067925169 @default.
• W4313478854 cites W2083296191 @default.
• W4313478854 cites W2120397493 @default.
• W4313478854 cites W2137358252 @default.
• W4313478854 cites W2147300912 @default.
• W4313478854 cites W2994663251 @default.
• W4313478854 cites W3034861237 @default.
• W4313478854 doi "https://doi.org/10.1016/j.jddst.2022.104138" @default.
• W4313478854 hasPublicationYear "2023" @default.
• W4313478854 type Work @default.
• W4313478854 citedByCount "0" @default.
• W4313478854 crossrefType "journal-article" @default.
• W4313478854 hasAuthorship W4313478854A5008702877 @default.
• W4313478854 hasAuthorship W4313478854A5016134338 @default.
• W4313478854 hasAuthorship W4313478854A5053069304 @default.
• W4313478854 hasAuthorship W4313478854A5069254991 @default.
• W4313478854 hasAuthorship W4313478854A5070593067 @default.
• W4313478854 hasAuthorship W4313478854A5085286170 @default.
• W4313478854 hasConcept C127413603 @default.
• W4313478854 hasConcept C14029885 @default.
• W4313478854 hasConcept C155574463 @default.
• W4313478854 hasConcept C159985019 @default.
• W4313478854 hasConcept C163588942 @default.
• W4313478854 hasConcept C171250308 @default.
• W4313478854 hasConcept C178790620 @default.
• W4313478854 hasConcept C185592680 @default.
• W4313478854 hasConcept C192562407 @default.
• W4313478854 hasConcept C2776035855 @default.
• W4313478854 hasConcept C2778540859 @default.
• W4313478854 hasConcept C2778958987 @default.
• W4313478854 hasConcept C2779820397 @default.
• W4313478854 hasConcept C2781448156 @default.
• W4313478854 hasConcept C42360764 @default.
• W4313478854 hasConcept C43617362 @default.
• W4313478854 hasConcept C45904493 @default.
• W4313478854 hasConcept C521977710 @default.
• W4313478854 hasConcept C55493867 @default.
• W4313478854 hasConcept C71924100 @default.
• W4313478854 hasConcept C77281830 @default.
• W4313478854 hasConcept C88380143 @default.
• W4313478854 hasConcept C9603476 @default.
• W4313478854 hasConcept C98274493 @default.
• W4313478854 hasConceptScore W4313478854C127413603 @default.
• W4313478854 hasConceptScore W4313478854C14029885 @default.
• W4313478854 hasConceptScore W4313478854C155574463 @default.
• W4313478854 hasConceptScore W4313478854C159985019 @default.
• W4313478854 hasConceptScore W4313478854C163588942 @default.
• W4313478854 hasConceptScore W4313478854C171250308 @default.
• W4313478854 hasConceptScore W4313478854C178790620 @default.
• W4313478854 hasConceptScore W4313478854C185592680 @default.
• W4313478854 hasConceptScore W4313478854C192562407 @default.
• W4313478854 hasConceptScore W4313478854C2776035855 @default.
• W4313478854 hasConceptScore W4313478854C2778540859 @default.
• W4313478854 hasConceptScore W4313478854C2778958987 @default.
• W4313478854 hasConceptScore W4313478854C2779820397 @default.
• W4313478854 hasConceptScore W4313478854C2781448156 @default.
• W4313478854 hasConceptScore W4313478854C42360764 @default.
• W4313478854 hasConceptScore W4313478854C43617362 @default.
• W4313478854 hasConceptScore W4313478854C45904493 @default.
• W4313478854 hasConceptScore W4313478854C521977710 @default.
• W4313478854 hasConceptScore W4313478854C55493867 @default.
• W4313478854 hasConceptScore W4313478854C71924100 @default.
• W4313478854 hasConceptScore W4313478854C77281830 @default.
• W4313478854 hasConceptScore W4313478854C88380143 @default.
• W4313478854 hasConceptScore W4313478854C9603476 @default.
• W4313478854 hasConceptScore W4313478854C98274493 @default.
• W4313478854 hasFunder F4320307765 @default.
• W4313478854 hasFunder F4320320719 @default.
• W4313478854 hasFunder F4320323448 @default.
• W4313478854 hasFunder F4320334771 @default.
• W4313478854 hasLocation W43134788541 @default.
• W4313478854 hasOpenAccess W4313478854 @default.

• next