FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313479139> ?p ?o ?g. }

• W4313479139 endingPage "100401" @default.
• W4313479139 startingPage "100401" @default.
• W4313479139 abstract "Caralluma dalzielii belongs to the family of Asclepiadiaceae. It is a succulent perennial plant widely distributed across the Sahel region from Senegal to Northwest Nigeria. Extracts from Caralluma dalzielii are used traditionally in the treatment of pain, infertility, epilepsy and other neurological diseases. The aim of the present study was to evaluate the anticonvulsant effects of aqueous extracts of aerial parts of Caralluma dalzielii using various experimental models. The anticonvulsant effect of the plant extract (250, 500 and 1000 mg/kg p.o) were assessed using maximal electroshock (MES) model in chicks, pentylenetetrazole (PTZ) and strychnine (STN)-induced seizures models in mice. Diazepam-induced sleep in chicks was used to study the sedative property of the plant. In the anticonvulsant and sedative property studies, the onset and duration of seizures and sleep were recorded respectively. The oral acute toxicity study was assessed. The extract was screened preliminarily for its phytochemicals and was further analysed using Gas chromatography-mass spectrometry (GC–MS) to identify its major chemical components. The oral acute toxicity studies showed that the LD50 was greater than 5000 mg/kg in mice. Pre-treatment of mice with the aqueous extract of Caralluma dalzielii produced a dose-dependent protection against PTZ-induced seizures and mortality with 100% protection at the highest dose of the extract. The extract also significantly increased the latency/onset of myoclonic jerks and reduced the duration of tonic seizures dose dependently. In STN-induced seizure, the extract had no protection against seizure induction similar to diazepam the positive control. However, it significantly (p < 0.05) prolonged the latency of seizure and increased the survival time before death in a dose dependent manner. Caralluma dalzielii had zero protection against maximal electroshock. Phytochemical screening showed the presence of flavonoids, tannins, saponins, steroids, glycosides, cardiac glycosides and phenols. GC–MS analysis revealed the presence of some compounds. The extract of Caralluma dalzielii possesses anticonvulsant activity with less marked sedative activity. It also contains several phytochemicals which may be responsible for the activity. This study serves to validate the use of this plant in folkloric medicine for the treatment of epilepsy and convulsions." @default.
• W4313479139 created "2023-01-06" @default.
• W4313479139 creator A5006060895 @default.
• W4313479139 creator A5026402366 @default.
• W4313479139 creator A5032426705 @default.
• W4313479139 creator A5049913947 @default.
• W4313479139 creator A5055339216 @default.
• W4313479139 creator A5065466817 @default.
• W4313479139 date "2023-02-01" @default.
• W4313479139 modified "2023-10-05" @default.
• W4313479139 title "An experimental evaluation of anticonvulsant activity of aqueous extract of Caralluma dalzielii N.E. Brown" @default.
• W4313479139 cites W1513502492 @default.
• W4313479139 cites W1975515446 @default.
• W4313479139 cites W1983417225 @default.
• W4313479139 cites W1988606072 @default.
• W4313479139 cites W2003731160 @default.
• W4313479139 cites W2020466457 @default.
• W4313479139 cites W2071489304 @default.
• W4313479139 cites W2089118340 @default.
• W4313479139 cites W2098742258 @default.
• W4313479139 cites W2102809109 @default.
• W4313479139 cites W2120091670 @default.
• W4313479139 cites W2161325705 @default.
• W4313479139 cites W2181121996 @default.
• W4313479139 cites W2367812079 @default.
• W4313479139 cites W2424607363 @default.
• W4313479139 cites W2518011077 @default.
• W4313479139 cites W2557017807 @default.
• W4313479139 cites W2563036039 @default.
• W4313479139 cites W2594644573 @default.
• W4313479139 cites W2607219456 @default.
• W4313479139 cites W2726666234 @default.
• W4313479139 cites W2763935507 @default.
• W4313479139 cites W2809625000 @default.
• W4313479139 cites W2890417736 @default.
• W4313479139 cites W2995459561 @default.
• W4313479139 cites W3044094857 @default.
• W4313479139 cites W3093317405 @default.
• W4313479139 cites W3130176330 @default.
• W4313479139 cites W3157699658 @default.
• W4313479139 cites W4200413925 @default.
• W4313479139 cites W4214486827 @default.
• W4313479139 cites W4220738089 @default.
• W4313479139 cites W4220848857 @default.
• W4313479139 doi "https://doi.org/10.1016/j.phyplu.2022.100401" @default.
• W4313479139 hasPublicationYear "2023" @default.
• W4313479139 type Work @default.
• W4313479139 citedByCount "2" @default.
• W4313479139 countsByYear W43134791392023 @default.
• W4313479139 crossrefType "journal-article" @default.
• W4313479139 hasAuthorship W4313479139A5006060895 @default.
• W4313479139 hasAuthorship W4313479139A5026402366 @default.
• W4313479139 hasAuthorship W4313479139A5032426705 @default.
• W4313479139 hasAuthorship W4313479139A5049913947 @default.
• W4313479139 hasAuthorship W4313479139A5055339216 @default.
• W4313479139 hasAuthorship W4313479139A5065466817 @default.
• W4313479139 hasBestOaLocation W43134791391 @default.
• W4313479139 hasConcept C116263406 @default.
• W4313479139 hasConcept C118552586 @default.
• W4313479139 hasConcept C126322002 @default.
• W4313479139 hasConcept C185592680 @default.
• W4313479139 hasConcept C2775858608 @default.
• W4313479139 hasConcept C2776175493 @default.
• W4313479139 hasConcept C2777010014 @default.
• W4313479139 hasConcept C2777602617 @default.
• W4313479139 hasConcept C2778186239 @default.
• W4313479139 hasConcept C29730261 @default.
• W4313479139 hasConcept C556039675 @default.
• W4313479139 hasConcept C71924100 @default.
• W4313479139 hasConcept C98274493 @default.
• W4313479139 hasConceptScore W4313479139C116263406 @default.
• W4313479139 hasConceptScore W4313479139C118552586 @default.
• W4313479139 hasConceptScore W4313479139C126322002 @default.
• W4313479139 hasConceptScore W4313479139C185592680 @default.
• W4313479139 hasConceptScore W4313479139C2775858608 @default.
• W4313479139 hasConceptScore W4313479139C2776175493 @default.
• W4313479139 hasConceptScore W4313479139C2777010014 @default.
• W4313479139 hasConceptScore W4313479139C2777602617 @default.
• W4313479139 hasConceptScore W4313479139C2778186239 @default.
• W4313479139 hasConceptScore W4313479139C29730261 @default.
• W4313479139 hasConceptScore W4313479139C556039675 @default.
• W4313479139 hasConceptScore W4313479139C71924100 @default.
• W4313479139 hasConceptScore W4313479139C98274493 @default.
• W4313479139 hasIssue "1" @default.
• W4313479139 hasLocation W43134791391 @default.
• W4313479139 hasOpenAccess W4313479139 @default.
• W4313479139 hasPrimaryLocation W43134791391 @default.
• W4313479139 hasRelatedWork W1505263022 @default.
• W4313479139 hasRelatedWork W2010246924 @default.
• W4313479139 hasRelatedWork W2044989620 @default.
• W4313479139 hasRelatedWork W2181386121 @default.
• W4313479139 hasRelatedWork W2431487876 @default.
• W4313479139 hasRelatedWork W2472926793 @default.
• W4313479139 hasRelatedWork W2736917669 @default.
• W4313479139 hasRelatedWork W2921289179 @default.
• W4313479139 hasRelatedWork W2967874650 @default.
• W4313479139 hasRelatedWork W2174961586 @default.
• W4313479139 hasVolume "3" @default.

• next