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• W4313479535 startingPage "115405" @default.
• W4313479535 abstract "Mitochondria and mitochondrial proteins represent a group of promising pharmacological target candidates in the search of new molecular targets and drugs to counteract the onset of hypertension and more in general cardiovascular diseases (CVDs). Indeed, several mitochondrial pathways result impaired in CVDs, showing ATP depletion and ROS production as common traits of cardiac tissue degeneration. Thus, targeting mitochondrial dysfunction in cardiomyocytes can represent a successful strategy to prevent heart failure. In this context, the identification of new pharmacological targets among mitochondrial proteins paves the way for the design of new selective drugs. Thanks to the advances in omics approaches, to a greater availability of mitochondrial crystallized protein structures and to the development of new computational approaches for protein 3D-modelling and drug design, it is now possible to investigate in detail impaired mitochondrial pathways in CVDs. Furthermore, it is possible to design new powerful drugs able to hit the selected pharmacological targets in a highly selective way to rescue mitochondrial dysfunction and prevent cardiac tissue degeneration. The role of mitochondrial dysfunction in the onset of CVDs appears increasingly evident, as reflected by the impairment of proteins involved in lipid peroxidation, mitochondrial dynamics, respiratory chain complexes, and membrane polarization maintenance in CVD patients. Conversely, little is known about proteins responsible for the cross-talk between mitochondria and cytoplasm in cardiomyocytes. Mitochondrial transporters of the SLC25A family, in particular, are responsible for the translocation of nucleotides (e.g., ATP), amino acids (e.g., aspartate, glutamate, ornithine), organic acids (e.g. malate and 2-oxoglutarate), and other cofactors (e.g., inorganic phosphate, NAD+, FAD, carnitine, CoA derivatives) between the mitochondrial and cytosolic compartments. Thus, mitochondrial transporters play a key role in the mitochondria-cytosol cross-talk by leading metabolic pathways such as the malate/aspartate shuttle, the carnitine shuttle, the ATP export from mitochondria, and the regulation of permeability transition pore opening. Since all these pathways are crucial for maintaining healthy cardiomyocytes, mitochondrial carriers emerge as an interesting class of new possible pharmacological targets for CVD treatments." @default.
• W4313479535 created "2023-01-06" @default.
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• W4313479535 date "2023-02-01" @default.
• W4313479535 modified "2023-10-05" @default.
• W4313479535 title "Targeting mitochondrial impairment for the treatment of cardiovascular diseases: From hypertension to ischemia-reperfusion injury, searching for new pharmacological targets" @default.
• W4313479535 cites W1518164444 @default.
• W4313479535 cites W1525841471 @default.
• W4313479535 cites W1530242502 @default.
• W4313479535 cites W1537523901 @default.
• W4313479535 cites W1555206873 @default.
• W4313479535 cites W1561394207 @default.
• W4313479535 cites W1573108780 @default.
• W4313479535 cites W1591646293 @default.
• W4313479535 cites W1597832360 @default.
• W4313479535 cites W1597914047 @default.
• W4313479535 cites W1603358246 @default.
• W4313479535 cites W1642939539 @default.
• W4313479535 cites W1657534147 @default.
• W4313479535 cites W1676981804 @default.
• W4313479535 cites W1715970343 @default.
• W4313479535 cites W1816261981 @default.
• W4313479535 cites W1818341268 @default.
• W4313479535 cites W1887914177 @default.
• W4313479535 cites W1936034626 @default.
• W4313479535 cites W1964690839 @default.
• W4313479535 cites W1967299846 @default.
• W4313479535 cites W1968320351 @default.
• W4313479535 cites W1968510168 @default.
• W4313479535 cites W1969913237 @default.
• W4313479535 cites W1970468997 @default.
• W4313479535 cites W1970822787 @default.
• W4313479535 cites W1973205178 @default.
• W4313479535 cites W1973399749 @default.
• W4313479535 cites W1973870901 @default.
• W4313479535 cites W1974395224 @default.
• W4313479535 cites W1974543672 @default.
• W4313479535 cites W1974689713 @default.
• W4313479535 cites W1975234868 @default.
• W4313479535 cites W1977142594 @default.
• W4313479535 cites W1978225623 @default.
• W4313479535 cites W1979415999 @default.
• W4313479535 cites W1980339513 @default.
• W4313479535 cites W1980560097 @default.
• W4313479535 cites W1980756616 @default.
• W4313479535 cites W1981168356 @default.
• W4313479535 cites W1981575376 @default.
• W4313479535 cites W1982479074 @default.
• W4313479535 cites W1982615445 @default.
• W4313479535 cites W1983330930 @default.
• W4313479535 cites W1987774527 @default.
• W4313479535 cites W1988936830 @default.
• W4313479535 cites W1989545610 @default.
• W4313479535 cites W1989760304 @default.
• W4313479535 cites W1993103335 @default.
• W4313479535 cites W1994270731 @default.
• W4313479535 cites W1995496906 @default.
• W4313479535 cites W1995873637 @default.
• W4313479535 cites W1995952100 @default.
• W4313479535 cites W1996001543 @default.
• W4313479535 cites W1996146434 @default.
• W4313479535 cites W1996583548 @default.
• W4313479535 cites W1997997206 @default.
• W4313479535 cites W1998869530 @default.
• W4313479535 cites W1999699035 @default.
• W4313479535 cites W1999952910 @default.
• W4313479535 cites W2000148777 @default.
• W4313479535 cites W2000221281 @default.
• W4313479535 cites W2000501615 @default.
• W4313479535 cites W2000864465 @default.
• W4313479535 cites W2001265990 @default.
• W4313479535 cites W2002088627 @default.
• W4313479535 cites W2002139629 @default.
• W4313479535 cites W2002926498 @default.
• W4313479535 cites W2003409824 @default.
• W4313479535 cites W2003991063 @default.
• W4313479535 cites W2004100670 @default.
• W4313479535 cites W2004224253 @default.
• W4313479535 cites W2004428815 @default.
• W4313479535 cites W2004691285 @default.

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