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• W4313479581 endingPage "130914" @default.
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• W4313479581 abstract "Smart drug delivery systems are responsive to stimulus factors such as temperature and frequency. However, there is no model for estimating the amount of drug release temperature and frequency from a nanocarrier moving in the human body in the literature. Therefore, this study aims to provide a mathematical model for estimating the amount of drug release temperature and frequency from a nanocarrier passing through the shunt pathway of skin layers. For this purpose, using the Timoshenko-Gere torsional theory, displacement field equations in the shunt pathway for the lipid nano-tubule are obtained. Then, using these equations, the strain energy of the lipid nano-tubule, as well as its kinetic energy, is calculated. After that, using kinetic energy, strain energy, skin temperature, and axial force, the governing equation of lipid nano-tubule dynamics in the skin layers is obtained. By solving the governing equation on the torsional movement of the nanocarrier, the critical temperature and the natural frequency in the presence of temperature are obtained. The obtained results show a drug release region from the nanocarrier, which depends on the body's internal conditions, has been obtained. This obtained region demonstrates that for a given temperature of the skin layers, there is a given stimulation frequency, which causes the collapse of the nano-lipid structure. Hence, the proposed model makes it possible to estimate the critical temperature and frequency stimulus for drug release in the skin layers. This model can be used to design smart drug release systems." @default.
• W4313479581 created "2023-01-06" @default.
• W4313479581 creator A5022184463 @default.
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• W4313479581 date "2023-03-01" @default.
• W4313479581 modified "2023-10-18" @default.
• W4313479581 title "Torsional vibration characteristics of lipid nanocarriers passing through skin layers" @default.
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• W4313479581 doi "https://doi.org/10.1016/j.colsurfa.2022.130914" @default.
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