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- W4313479975 abstract "Antimicrobial peptides (AMPs) play essential roles in defending against various invading pathogens. Although antibacterial or antifungal properties of AMPs have been well characterized, the contribution of AMPs to immune defenses against viruses especially baculoviruses is still unclear. In this study, four full-length AMP genes (Ldcec, Ldatt, Ldglo and Ldmor) that encode the cecropin, attacin, gloverin and moricin, respectively, were characterized in Lymantria dispar (Asian gypsy moth). All four AMPs were cationic peptides and exhibited hydrophilicity. Structural analysis showed that the Ldcec and Ldmor were α-helical peptides. Tissue-specific Ldcec expression was the highest in fat body, while expression of Ldatt, Ldglo and Ldmor was the highest in epidermis. All four AMP genes were expressed during all developmental stages with the highest expression in the pupa and adult. Compared to mock infection, expression of these four AMP genes were significantly induced following Lymantria dispar multiple nucleopolyhedrovirus (LdMNPV) challenge and sharply increased at 72 h post infection. After Ldglo gene silencing, the DNA replication levels of LdMNPV in L. dispar larvae significantly increased at 48 and 72 h post infection, indicating that the Ldglo could suppress the DNA replication of LdMNPV. Our results suggest that four AMPs of L. dispar may play important roles in antiviral immunity against LdMNPV." @default.
- W4313479975 created "2023-01-06" @default.
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- W4313479975 date "2023-02-01" @default.
- W4313479975 modified "2023-09-27" @default.
- W4313479975 title "Four antimicrobial peptides of Asian gypsy moth respond to infection of its viral pathogen, nucleopolyhedrovirus (LdMNPV)" @default.
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- W4313479975 doi "https://doi.org/10.1016/j.pestbp.2022.105335" @default.
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