Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313480024> ?p ?o ?g. }
- W4313480024 endingPage "100988" @default.
- W4313480024 startingPage "100988" @default.
- W4313480024 abstract "We have synthesized fourteen thiazole bearing thiourea derivatives (1–14), characterized through different techniques i.e., NMR, HR-EIMS and tested against acetylcholinesterase and butyrylcholinesterase inhibitory potentials. All analogues showed inhibitory potential having varied IC50 values ranged from 2.10 ± 0.02 to 109.40 ± 0.04 µM (for AChE) and 3.10 ± 0.01 to 102.20 ± 0.04 µM (for BuChE) as compared to standard drug Eserine (IC50 = 0.85 ± 0.0001 & 0.04 ± 0.0001 µM respectively). Among the series, analogues 6, 11, 7 and 12 displayed excellent inhibitory potential against acetylcholinesterase. Analogue 14 (IC50 = 3.10 ± 0.01 µM) was found to be most potent against butyrylcholinesterase. Structure activity relationship (SAR) was established depend upon nature, position and number of substituent/s attached to the phenyl ring of basic nucleus. Molecular docking study was carried out to check the binding interaction of most potent analogues with the active site of enzyme." @default.
- W4313480024 created "2023-01-06" @default.
- W4313480024 creator A5007069121 @default.
- W4313480024 creator A5022664070 @default.
- W4313480024 creator A5037474094 @default.
- W4313480024 creator A5039833072 @default.
- W4313480024 creator A5047089632 @default.
- W4313480024 creator A5047672519 @default.
- W4313480024 creator A5058571254 @default.
- W4313480024 creator A5066602866 @default.
- W4313480024 creator A5081708163 @default.
- W4313480024 creator A5086422606 @default.
- W4313480024 date "2023-04-01" @default.
- W4313480024 modified "2023-09-27" @default.
- W4313480024 title "Synthesis, acetylcholinesterase and butyrylcholinesterase inhibitory potential and molecular docking study of thiazole bearing thiourea analogues" @default.
- W4313480024 cites W1174807774 @default.
- W4313480024 cites W1948326274 @default.
- W4313480024 cites W1965778750 @default.
- W4313480024 cites W1971048984 @default.
- W4313480024 cites W1981775239 @default.
- W4313480024 cites W2000103982 @default.
- W4313480024 cites W2006522535 @default.
- W4313480024 cites W2018919593 @default.
- W4313480024 cites W2085130089 @default.
- W4313480024 cites W2089303115 @default.
- W4313480024 cites W2107857520 @default.
- W4313480024 cites W2108507435 @default.
- W4313480024 cites W2111863354 @default.
- W4313480024 cites W2143120360 @default.
- W4313480024 cites W2268366841 @default.
- W4313480024 cites W2396511775 @default.
- W4313480024 cites W2399368015 @default.
- W4313480024 cites W2460062919 @default.
- W4313480024 cites W2505843028 @default.
- W4313480024 cites W2603725361 @default.
- W4313480024 cites W2737373991 @default.
- W4313480024 cites W2737953027 @default.
- W4313480024 cites W2742338598 @default.
- W4313480024 cites W2765227482 @default.
- W4313480024 cites W2766407160 @default.
- W4313480024 cites W2770086810 @default.
- W4313480024 cites W2792473069 @default.
- W4313480024 cites W2805853181 @default.
- W4313480024 cites W2810415842 @default.
- W4313480024 cites W2883630285 @default.
- W4313480024 cites W2947766942 @default.
- W4313480024 cites W2948910904 @default.
- W4313480024 cites W2951402893 @default.
- W4313480024 cites W2969863496 @default.
- W4313480024 cites W2979460486 @default.
- W4313480024 cites W2982033718 @default.
- W4313480024 cites W2996843863 @default.
- W4313480024 cites W3014685272 @default.
- W4313480024 cites W3025112645 @default.
- W4313480024 cites W3035948179 @default.
- W4313480024 cites W3039476755 @default.
- W4313480024 cites W3088617420 @default.
- W4313480024 cites W3092513245 @default.
- W4313480024 cites W3177448875 @default.
- W4313480024 cites W3203521117 @default.
- W4313480024 cites W4205392357 @default.
- W4313480024 cites W4296354130 @default.
- W4313480024 cites W4307944928 @default.
- W4313480024 cites W4312054457 @default.
- W4313480024 cites W4312070909 @default.
- W4313480024 cites W857389971 @default.
- W4313480024 doi "https://doi.org/10.1016/j.cdc.2022.100988" @default.
- W4313480024 hasPublicationYear "2023" @default.
- W4313480024 type Work @default.
- W4313480024 citedByCount "0" @default.
- W4313480024 crossrefType "journal-article" @default.
- W4313480024 hasAuthorship W4313480024A5007069121 @default.
- W4313480024 hasAuthorship W4313480024A5022664070 @default.
- W4313480024 hasAuthorship W4313480024A5037474094 @default.
- W4313480024 hasAuthorship W4313480024A5039833072 @default.
- W4313480024 hasAuthorship W4313480024A5047089632 @default.
- W4313480024 hasAuthorship W4313480024A5047672519 @default.
- W4313480024 hasAuthorship W4313480024A5058571254 @default.
- W4313480024 hasAuthorship W4313480024A5066602866 @default.
- W4313480024 hasAuthorship W4313480024A5081708163 @default.
- W4313480024 hasAuthorship W4313480024A5086422606 @default.
- W4313480024 hasConcept C159110408 @default.
- W4313480024 hasConcept C169760540 @default.
- W4313480024 hasConcept C17077164 @default.
- W4313480024 hasConcept C178790620 @default.
- W4313480024 hasConcept C181199279 @default.
- W4313480024 hasConcept C185592680 @default.
- W4313480024 hasConcept C202751555 @default.
- W4313480024 hasConcept C2777752497 @default.
- W4313480024 hasConcept C2778464347 @default.
- W4313480024 hasConcept C2778689049 @default.
- W4313480024 hasConcept C2778816929 @default.
- W4313480024 hasConcept C2779059548 @default.
- W4313480024 hasConcept C2779101902 @default.
- W4313480024 hasConcept C2780538656 @default.
- W4313480024 hasConcept C41685203 @default.
- W4313480024 hasConcept C55493867 @default.
- W4313480024 hasConcept C71240020 @default.