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• W4313480122 startingPage "105" @default.
• W4313480122 abstract "RNautophagy/DNautophagy (RDA) is an autophagic process that refers to the direct uptake of nucleic acids by lysosomes for degradation. Autophagy relies on lysosomes and lysosomal acidification is crucial for the degradation of intracellular components. However, whether lysosomal acidification interferes with nucleic acid uptake during RDA is unclear. In this study, we focused on vacuolar H+-ATPase (V-ATPase), the major proton pump responsible for maintaining an acidic pH in lysosomes. Our results show that lysosomes take up nucleic acids independently of the intralysosomal acidic pH during RDA. Isolated lysosomes treated with bafilomycin A1, a potent V-ATPase inhibitor, did not degrade, but took up RNA at similar levels as the control lysosomes. Similarly, the knockdown of Atp6v1a, the gene that encodes V-ATPase catalytic subunit A, did not affect the RNA uptake ability of isolated lysosomes. In addition, we demonstrated that nucleic acid uptake by isolated lysosomes necessitates ATP consumption, although V-ATPase is not required for the uptake process. These results broaden our understanding of the mechanisms underlying nucleic acid degradation via autophagy." @default.
• W4313480122 created "2023-01-06" @default.
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• W4313480122 date "2023-02-01" @default.
• W4313480122 modified "2023-10-14" @default.
• W4313480122 title "Nucleic acid uptake occurs independent of lysosomal acidification but dependent on ATP consumption during RNautophagy/DNautophagy" @default.
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• W4313480122 doi "https://doi.org/10.1016/j.bbrc.2022.12.090" @default.
• W4313480122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36640664" @default.
• W4313480122 hasPublicationYear "2023" @default.
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