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• W4313480143 endingPage "100582" @default.
• W4313480143 startingPage "100582" @default.
• W4313480143 abstract "Ibuprofen, a non-steroidal, anti-inflammatory drug, modulates inflammation but may also have neuroprotective effects on brain health that are poorly understood. Astrocyte-enriched extracellular vesicles (AEEVs) facilitate cell-to-cell communication and - among other functions - regulate inflammation and metabolism via microribonucleic acids (miRNAs). Dysfunctions in reward-related processing and inflammation have been proposed to be critical pathophysiological pathways in individuals with mood disorders. This investigation examined whether changes in AEEV cargo induced by an anti-inflammatory agent results in inflammatory modulation that is associated with reward-related processing. Data from a double-blind, randomized, repeated-measures study in healthy volunteers were used to examine the effects of AEEV miRNAs on brain activation during reward-related processing. In three separate visits, healthy participants (N = 20) received a single dose of either placebo, 200 mg, or 600 mg of ibuprofen, completed the monetary incentive delay task during functional magnetic resonance imaging, and provided a blood sample for cytokine and AEEV collection. AEEV miRNA content profiling showed that ibuprofen dose-dependently increased AEEV miR-23b-3p expression with greater increase following the 600 mg administration than placebo. Those individuals who received 600 mg and showed the highest miR-23b-3p expression also showed the (a) lowest serum tumor necrosis factor (TNF) and interleukin-17A (IL-17A) concentrations; and had the (b) highest striatal brain activation during reward anticipation. These results support the hypothesis that ibuprofen alters the composition of miRNAs in AEEVs. This opens the possibility that AEEV cargo could be used to modulate brain processes that are important for mental health." @default.
• W4313480143 created "2023-01-06" @default.
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• W4313480143 date "2023-02-01" @default.
• W4313480143 modified "2023-10-14" @default.
• W4313480143 title "Association between inflammation, reward processing, and ibuprofen-induced increases of miR-23b in astrocyte-enriched extracellular vesicles: A randomized, placebo-controlled, double-blind, exploratory trial in healthy individuals" @default.
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• W4313480143 cites W1591138153 @default.
• W4313480143 cites W1594747697 @default.
• W4313480143 cites W1967922673 @default.
• W4313480143 cites W1968499632 @default.
• W4313480143 cites W1971210455 @default.
• W4313480143 cites W1973155283 @default.
• W4313480143 cites W2000897683 @default.
• W4313480143 cites W2012129255 @default.
• W4313480143 cites W2015519617 @default.
• W4313480143 cites W2018681635 @default.
• W4313480143 cites W202007074 @default.
• W4313480143 cites W2042095978 @default.
• W4313480143 cites W2074661552 @default.
• W4313480143 cites W2098622411 @default.
• W4313480143 cites W2100036649 @default.
• W4313480143 cites W2104907299 @default.
• W4313480143 cites W2111583447 @default.
• W4313480143 cites W2116641097 @default.
• W4313480143 cites W2117140276 @default.
• W4313480143 cites W2117649346 @default.
• W4313480143 cites W2138889905 @default.
• W4313480143 cites W2140131793 @default.
• W4313480143 cites W2150557231 @default.
• W4313480143 cites W2159967773 @default.
• W4313480143 cites W2163199119 @default.
• W4313480143 cites W2170688212 @default.
• W4313480143 cites W2266423547 @default.
• W4313480143 cites W2331763492 @default.
• W4313480143 cites W2369811890 @default.
• W4313480143 cites W2511346649 @default.
• W4313480143 cites W2562654369 @default.
• W4313480143 cites W2571510181 @default.
• W4313480143 cites W2586399847 @default.
• W4313480143 cites W2592834759 @default.
• W4313480143 cites W2594599876 @default.
• W4313480143 cites W2599601965 @default.
• W4313480143 cites W2600760992 @default.
• W4313480143 cites W2606283522 @default.
• W4313480143 cites W2734508223 @default.
• W4313480143 cites W2744386347 @default.
• W4313480143 cites W2752476591 @default.
• W4313480143 cites W2786215739 @default.
• W4313480143 cites W2801610489 @default.
• W4313480143 cites W2809808727 @default.
• W4313480143 cites W2809933832 @default.
• W4313480143 cites W2811095131 @default.
• W4313480143 cites W2892840228 @default.
• W4313480143 cites W2911503339 @default.
• W4313480143 cites W2937452922 @default.
• W4313480143 cites W2943996957 @default.
• W4313480143 cites W2944182731 @default.
• W4313480143 cites W2944192957 @default.
• W4313480143 cites W2944697917 @default.
• W4313480143 cites W2973656741 @default.
• W4313480143 cites W2983808795 @default.
• W4313480143 cites W2989977128 @default.
• W4313480143 cites W2999291880 @default.
• W4313480143 cites W3013857818 @default.
• W4313480143 cites W3045916251 @default.
• W4313480143 cites W3082537212 @default.
• W4313480143 cites W3119992058 @default.
• W4313480143 cites W3124342844 @default.
• W4313480143 cites W3164179953 @default.
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• W4313480143 cites W3204631913 @default.
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• W4313480143 doi "https://doi.org/10.1016/j.bbih.2022.100582" @default.
• W4313480143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36605933" @default.
• W4313480143 hasPublicationYear "2023" @default.
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