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• W4313481518 endingPage "101473" @default.
• W4313481518 startingPage "101473" @default.
• W4313481518 abstract "Although polyetheretherketone has prospective applications in bone repair, its biological inertness limits its application. In this article, a high-strength porous polyetheretherketone/hydroxyapatite composite (hp-PK-HA) was developed through thermally induced phase separation and hydrothermal synthesis methods. The synthesized hp-PK-HA possesses an interconnected pore structure. The mechanical properties and porosity can be adjusted by changing the solid content. The maximum compressive modulus of the synthesized material is close to 1 GPa, and the porosity is between 30% and 60%, which conforms to the physical structure of the human skeleton. In vitro osteoblast differentiation experiments, compared with nonporous injection-molded polyetheretherketone (IM-PK) and high-strength porous polyetheretherketone (hp-PK, without HA), hp-PK-HA exhibited an outstanding osteogenic differentiation capacity in alkaline phosphatase (ALP), alizarin red S (ARS) and polymerase chain reaction (PCR) assays. In rat calvarial defects experiments, hp-PK-HA exhibited excellent osseointegration and bone regeneration ability and was confirmed by microcomputed tomography analysis, hard tissue sections, and immunohistochemistry staining. Overall, polyetheretherketone/hydroxyapatite composites may provide an efficient platform for the treatment of bone defects." @default.
• W4313481518 created "2023-01-06" @default.
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• W4313481518 date "2023-02-01" @default.
• W4313481518 modified "2023-09-30" @default.
• W4313481518 title "High-strength porous polyetheretherketone/hydroxyapatite composite for the treatment of bone defect" @default.
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• W4313481518 doi "https://doi.org/10.1016/j.coco.2022.101473" @default.
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