FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313481927> ?p ?o ?g. }

• W4313481927 abstract "The lateral cortex of the inferior colliculus (LCIC) is a midbrain shell region that receives multimodal inputs that target discrete zones of its compartmental (modular-matrix) framework. This arrangement emerges perinatally in mice (postnatal day, P0-P12) as somatosensory and auditory inputs segregate into their respective modular and matrix terminal patterns. Microglial cells (MGCs) perform a variety of critical functions in the developing brain, among them identifying areas of active circuit assembly and selectively pruning exuberant or underutilized connections. Recent evidence in other brain structures suggest considerable MGC heterogeneity across the lifespan, particularly during established developmental critical periods. The present study examines the potential involvement of classical complement cascade signaling (C3-CR3/CD11b) in refining early multisensory networks, and identifies several microglial subsets exhibiting distinct molecular signatures within the nascent LCIC. Immunostaining was performed in GAD67-green fluorescent protein (GFP) and CX3CR1-GFP mice throughout and after the defined LCIC critical period. GAD labeling highlights the emerging LCIC modularity, while CX3CR1 labeling depicts MGCs expressing the fractalkine receptor. C3 expression is widespread throughout the LCIC neuropil early on, prior to its conspicuous absence from modular zones at P8, and more global disappearance following critical period closure. CD11b-expressing microglia while homogeneously distributed at birth, are biased to modular fields at P8 and then the surrounding matrix by P12. Temporal and spatial matching of the disappearance of C3 by LCIC compartment (i.e., modules then matrix) with CD11b-positive MGC occupancy implicates complement signaling in the selective refinement of early LCIC connectivity. Multiple-labeling studies for a variety of established MGC markers (CD11b, CX3CR1, Iba1, TMEM119) indicate significant MGC heterogeneity in the LCIC as its compartments and segregated multisensory maps emerge. Marker colocalization was the exception rather than the rule, suggesting that unique MGC subpopulations exist in the LCIC and perhaps serve distinct developmental roles. Potential mechanisms whereby microglia sculpt early multisensory LCIC maps and how such activity/inactivity may underlie certain neurodevelopmental conditions, including autism spectrum disorder and schizophrenia, are discussed." @default.
• W4313481927 created "2023-01-06" @default.
• W4313481927 creator A5045470462 @default.
• W4313481927 creator A5056065914 @default.
• W4313481927 creator A5090065725 @default.
• W4313481927 date "2023-01-04" @default.
• W4313481927 modified "2023-09-30" @default.
• W4313481927 title "Microglial heterogeneity and complement component 3 elimination within emerging multisensory midbrain compartments during an early critical period" @default.
• W4313481927 cites W1168911763 @default.
• W4313481927 cites W1560207168 @default.
• W4313481927 cites W1611849651 @default.
• W4313481927 cites W1963788090 @default.
• W4313481927 cites W1974072126 @default.
• W4313481927 cites W1980789245 @default.
• W4313481927 cites W1995647101 @default.
• W4313481927 cites W1996055705 @default.
• W4313481927 cites W1997318952 @default.
• W4313481927 cites W2018686878 @default.
• W4313481927 cites W2018794746 @default.
• W4313481927 cites W2019710604 @default.
• W4313481927 cites W2021208291 @default.
• W4313481927 cites W2023962370 @default.
• W4313481927 cites W2029778231 @default.
• W4313481927 cites W2033617297 @default.
• W4313481927 cites W2038171883 @default.
• W4313481927 cites W2046117723 @default.
• W4313481927 cites W2062121261 @default.
• W4313481927 cites W2064919242 @default.
• W4313481927 cites W2076939471 @default.
• W4313481927 cites W2090645044 @default.
• W4313481927 cites W2096327192 @default.
• W4313481927 cites W2105107414 @default.
• W4313481927 cites W2105467224 @default.
• W4313481927 cites W2108994842 @default.
• W4313481927 cites W2113946516 @default.
• W4313481927 cites W2116428649 @default.
• W4313481927 cites W2120911948 @default.
• W4313481927 cites W2122037893 @default.
• W4313481927 cites W2137395087 @default.
• W4313481927 cites W2137578797 @default.
• W4313481927 cites W2151241903 @default.
• W4313481927 cites W2161057248 @default.
• W4313481927 cites W2163487275 @default.
• W4313481927 cites W2167279371 @default.
• W4313481927 cites W2225188179 @default.
• W4313481927 cites W2235653833 @default.
• W4313481927 cites W2280077905 @default.
• W4313481927 cites W2327995800 @default.
• W4313481927 cites W2546098128 @default.
• W4313481927 cites W2581555582 @default.
• W4313481927 cites W2615653072 @default.
• W4313481927 cites W2621173100 @default.
• W4313481927 cites W2725043130 @default.
• W4313481927 cites W2738168854 @default.
• W4313481927 cites W2740570637 @default.
• W4313481927 cites W2744052980 @default.
• W4313481927 cites W2758053316 @default.
• W4313481927 cites W2767486883 @default.
• W4313481927 cites W2791010802 @default.
• W4313481927 cites W2888906443 @default.
• W4313481927 cites W2896935109 @default.
• W4313481927 cites W2901838561 @default.
• W4313481927 cites W2902505080 @default.
• W4313481927 cites W2914756534 @default.
• W4313481927 cites W2949996247 @default.
• W4313481927 cites W2950077279 @default.
• W4313481927 cites W2950336920 @default.
• W4313481927 cites W2959600977 @default.
• W4313481927 cites W2989325449 @default.
• W4313481927 cites W2990866005 @default.
• W4313481927 cites W3004544639 @default.
• W4313481927 cites W3032487381 @default.
• W4313481927 cites W3040942181 @default.
• W4313481927 cites W3043564097 @default.
• W4313481927 cites W3047765583 @default.
• W4313481927 cites W3066755902 @default.
• W4313481927 cites W3114419121 @default.
• W4313481927 cites W3126069866 @default.
• W4313481927 cites W3139537842 @default.
• W4313481927 cites W3157093074 @default.
• W4313481927 cites W3199494145 @default.
• W4313481927 cites W4200608662 @default.
• W4313481927 cites W4225854549 @default.
• W4313481927 doi "https://doi.org/10.3389/fnins.2022.1072667" @default.
• W4313481927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36685243" @default.
• W4313481927 hasPublicationYear "2023" @default.
• W4313481927 type Work @default.
• W4313481927 citedByCount "0" @default.
• W4313481927 crossrefType "journal-article" @default.
• W4313481927 hasAuthorship W4313481927A5045470462 @default.
• W4313481927 hasAuthorship W4313481927A5056065914 @default.
• W4313481927 hasAuthorship W4313481927A5090065725 @default.
• W4313481927 hasBestOaLocation W43134819271 @default.
• W4313481927 hasConcept C12823836 @default.
• W4313481927 hasConcept C13373296 @default.
• W4313481927 hasConcept C169760540 @default.
• W4313481927 hasConcept C170493617 @default.
• W4313481927 hasConcept C203014093 @default.
• W4313481927 hasConcept C2775980177 @default.
• W4313481927 hasConcept C2776914184 @default.

• next