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- W4313482857 endingPage "e202201594" @default.
- W4313482857 startingPage "e202201594" @default.
- W4313482857 abstract "Replication licensing, a prerequisite of DNA replication, helps to ensure once-per-cell-cycle genome duplication. Some DNA replication-initiation proteins are sequentially loaded onto replication origins to form pre-replicative complexes (pre-RCs). ORC and Noc3p bind replication origins throughout the cell cycle, providing a platform for pre-RC assembly. We previously reported that cell cycle-dependent ORC dimerization is essential for the chromatin loading of the symmetric MCM double-hexamers. Here, we used Saccharomyces cerevisiae separation-of-function NOC3 mutants to confirm the separable roles of Noc3p in DNA replication and ribosome biogenesis. We also show that an essential and cell cycle-dependent Noc3p dimerization cycle regulates the ORC dimerization cycle. Noc3p dimerizes at the M-to-G1 transition and de-dimerizes in S-phase. The Noc3p dimerization cycle coupled with the ORC dimerization cycle enables replication licensing, protects nascent sister replication origins after replication initiation, and prevents re-replication. This study has revealed a new mechanism of replication licensing and elucidated the molecular mechanism of Noc3p as a mediator of ORC dimerization in pre-RC formation." @default.
- W4313482857 created "2023-01-06" @default.
- W4313482857 creator A5003815010 @default.
- W4313482857 creator A5013267503 @default.
- W4313482857 creator A5013824415 @default.
- W4313482857 creator A5033436119 @default.
- W4313482857 creator A5064347182 @default.
- W4313482857 creator A5068260072 @default.
- W4313482857 creator A5068851873 @default.
- W4313482857 creator A5070475024 @default.
- W4313482857 creator A5088432822 @default.
- W4313482857 date "2023-01-04" @default.
- W4313482857 modified "2023-10-02" @default.
- W4313482857 title "An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing" @default.
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- W4313482857 doi "https://doi.org/10.26508/lsa.202201594" @default.