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- W4313482875 abstract "Aging is accompanied with progressive deterioration of immune responses and tissue's function. Using 12-month-old mice as model, we showed that conditioned medium of human cord blood mesenchymal stem cells (CBMSC-CM) significantly reduced the population percentage of CD3-CD335+ NK and CD4+CD25+ regulatory T-cells in peripheral blood. The CBMSC-CM administration also increased naïve T-cells number and restored the ratio of naïve to memory T-cells in CD4+ T-cells population. These results indicated that CBMSC-CM improved the immune response efficiency of aged mice. Moreover, we also found CBMSC-CM treatment significantly reduced the number of senescenT-cells in kidney tissues. Finally, we demonstrated that CBMSC-CM remarkably attenuated hydrogen peroxide triggered T-cell response and ameliorated oxidative stress induced cellular senescence. All of these data suggest a prominent anti-aging effect of secretome of CBMSCs." @default.
- W4313482875 created "2023-01-06" @default.
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- W4313482875 date "2023-01-04" @default.
- W4313482875 modified "2023-09-29" @default.
- W4313482875 title "Conditioned medium from human cord blood mesenchymal stem cells attenuates age-related immune dysfunctions" @default.
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- W4313482875 doi "https://doi.org/10.3389/fcell.2022.1042609" @default.
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