FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313482947> ?p ?o ?g. }

• W4313482947 abstract "Objective To describe the clinical and radiological features, as well as outcomes following glucocorticoid therapy and recurrence in adults suffering from cortical encephalitis associated with myelin oligodendrocyte glycoprotein (MOG) antibody. Methods The clinical information of nine adult patients suffering from cortical encephalitis associated with MOG antibody admitted to the Affiliated Brain Hospital of Nanjing Medical University from 2020 to 2022 was systematically reviewed. The clinical symptoms, laboratory data, imaging results, outcomes following glucocorticoid therapy and recurrence were evaluated. Result A total of 9 patients positive for MOG antibody and suffering from cortical encephalitis were included in our study (55.6% men, median age 29 years, 15–57 years). The most common clinical symptoms included headache (77.8%), fever (66.7%), and generalized seizures (55.6%). Some patients also experienced limb shaking (22.2%), leg numbness (22.2%), transient motor aphasia (11.1%), and vision loss (11.1%). The main features of cerebrospinal fluid () examination were increased intracranial pressure, pleocytosis, and elevated cerebrospinal fluid (CSF) protein. In addition, N-methyl-D-aspartate receptor (NMDAR) and MOG antibodies were found in the CSF of 3 patients, and NMDAR, MOG, and glial fibrillary acidic protein antibodies were found in the CSF of 1 patient. All patients were subjected to magnetic resonance imaging (MRI) and the images of eight of them showed T2 and/flair image hyperintense lesions, three showed meningeal or lesion enhancement and four showed white matter lesions, which were mostly located in the midline structures (75%). All patients received glucocorticoid therapy in the acute phase and in remission, and eight of them received an intravenous high dose of methylprednisolone, including one patient who received a simultaneous immunoglobulin therapy. One patient was treated with low-dose prednisolone tablets. Seven (77.8%) patients were wholly recovered at discharge, and 2 (22.2%) patients were left with slight symptoms. During the median 9-month follow-up (range: 2–36 months), 2 (22.2%) patients developed recurrence. Conclusion The clinical manifestations of adult MOG antibody-associated cortical encephalitis were significantly different from those of the typical MOG antibody-associated disease (MOGAD). Patients in the acute phase of the disease were prone to show signs similar to central nervous system infection, requiring clinicians to have the ability to recognize the disease to avoid misdiagnosis. In addition, seizures were common in MOG antibody-related encephalitis, and the type of seizures was age-related. Brain MRI results showed that the distribution of cerebral cortex lesions was closely related to the classification of cortical encephalitis. Based on the patient’s response to the treatment, glucocorticoid therapy was effective against MOG antibody-associated cortical encephalitis, which is consistent with the treatment response and clinical prognosis of MOGAD. Therefore, our opinion was that MOG antibody might be the “responsible antibody” in MOG antibody-associated cortical encephalitis, although further studies are needed to confirm this hypothesis." @default.
• W4313482947 created "2023-01-06" @default.
• W4313482947 creator A5038991638 @default.
• W4313482947 creator A5061612331 @default.
• W4313482947 creator A5062284542 @default.
• W4313482947 creator A5062361637 @default.
• W4313482947 creator A5064360081 @default.
• W4313482947 creator A5069586887 @default.
• W4313482947 date "2023-01-04" @default.
• W4313482947 modified "2023-10-14" @default.
• W4313482947 title "Clinical characteristic of myelin oligodendrocyte glycoprotein antibody associated cortical encephalitis in adults and outcomes following glucocorticoid therapy" @default.
• W4313482947 cites W2051552021 @default.
• W4313482947 cites W2052652578 @default.
• W4313482947 cites W2067553108 @default.
• W4313482947 cites W2078631326 @default.
• W4313482947 cites W2103812851 @default.
• W4313482947 cites W2131887019 @default.
• W4313482947 cites W2154982729 @default.
• W4313482947 cites W2159831122 @default.
• W4313482947 cites W2163022996 @default.
• W4313482947 cites W2206286096 @default.
• W4313482947 cites W2280783985 @default.
• W4313482947 cites W2511961989 @default.
• W4313482947 cites W2542372902 @default.
• W4313482947 cites W2578761578 @default.
• W4313482947 cites W2588433579 @default.
• W4313482947 cites W2751535586 @default.
• W4313482947 cites W2757463541 @default.
• W4313482947 cites W2800192720 @default.
• W4313482947 cites W2810793640 @default.
• W4313482947 cites W2888355099 @default.
• W4313482947 cites W2902136400 @default.
• W4313482947 cites W2903500787 @default.
• W4313482947 cites W2905137679 @default.
• W4313482947 cites W2914411623 @default.
• W4313482947 cites W2941915623 @default.
• W4313482947 cites W2956073307 @default.
• W4313482947 cites W2956114581 @default.
• W4313482947 cites W3004592781 @default.
• W4313482947 cites W3006216901 @default.
• W4313482947 cites W3040956781 @default.
• W4313482947 cites W3113265471 @default.
• W4313482947 cites W3115895696 @default.
• W4313482947 cites W3139533812 @default.
• W4313482947 cites W3171431518 @default.
• W4313482947 cites W3194868089 @default.
• W4313482947 cites W3195674796 @default.
• W4313482947 cites W3196931109 @default.
• W4313482947 cites W4220896822 @default.
• W4313482947 cites W4306181642 @default.
• W4313482947 doi "https://doi.org/10.3389/fnagi.2022.1076361" @default.
• W4313482947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36688157" @default.
• W4313482947 hasPublicationYear "2023" @default.
• W4313482947 type Work @default.
• W4313482947 citedByCount "0" @default.
• W4313482947 crossrefType "journal-article" @default.
• W4313482947 hasAuthorship W4313482947A5038991638 @default.
• W4313482947 hasAuthorship W4313482947A5061612331 @default.
• W4313482947 hasAuthorship W4313482947A5062284542 @default.
• W4313482947 hasAuthorship W4313482947A5062361637 @default.
• W4313482947 hasAuthorship W4313482947A5064360081 @default.
• W4313482947 hasAuthorship W4313482947A5069586887 @default.
• W4313482947 hasBestOaLocation W43134829471 @default.
• W4313482947 hasConcept C101070640 @default.
• W4313482947 hasConcept C126322002 @default.
• W4313482947 hasConcept C126838900 @default.
• W4313482947 hasConcept C142724271 @default.
• W4313482947 hasConcept C143409427 @default.
• W4313482947 hasConcept C203014093 @default.
• W4313482947 hasConcept C2522874641 @default.
• W4313482947 hasConcept C2777483564 @default.
• W4313482947 hasConcept C2778609137 @default.
• W4313482947 hasConcept C2779357208 @default.
• W4313482947 hasConcept C2779651940 @default.
• W4313482947 hasConcept C2780841215 @default.
• W4313482947 hasConcept C529278444 @default.
• W4313482947 hasConcept C71924100 @default.
• W4313482947 hasConcept C83455156 @default.
• W4313482947 hasConcept C90924648 @default.
• W4313482947 hasConceptScore W4313482947C101070640 @default.
• W4313482947 hasConceptScore W4313482947C126322002 @default.
• W4313482947 hasConceptScore W4313482947C126838900 @default.
• W4313482947 hasConceptScore W4313482947C142724271 @default.
• W4313482947 hasConceptScore W4313482947C143409427 @default.
• W4313482947 hasConceptScore W4313482947C203014093 @default.
• W4313482947 hasConceptScore W4313482947C2522874641 @default.
• W4313482947 hasConceptScore W4313482947C2777483564 @default.
• W4313482947 hasConceptScore W4313482947C2778609137 @default.
• W4313482947 hasConceptScore W4313482947C2779357208 @default.
• W4313482947 hasConceptScore W4313482947C2779651940 @default.
• W4313482947 hasConceptScore W4313482947C2780841215 @default.
• W4313482947 hasConceptScore W4313482947C529278444 @default.
• W4313482947 hasConceptScore W4313482947C71924100 @default.
• W4313482947 hasConceptScore W4313482947C83455156 @default.
• W4313482947 hasConceptScore W4313482947C90924648 @default.
• W4313482947 hasLocation W43134829471 @default.
• W4313482947 hasLocation W43134829472 @default.
• W4313482947 hasLocation W43134829473 @default.
• W4313482947 hasOpenAccess W4313482947 @default.
• W4313482947 hasPrimaryLocation W43134829471 @default.

• next