Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313483818> ?p ?o ?g. }
- W4313483818 endingPage "761" @default.
- W4313483818 startingPage "752" @default.
- W4313483818 abstract "Acute viral infections can have durable functional impacts on the immune system long after recovery, but how they affect homeostatic immune states and responses to future perturbations remain poorly understood1-4. Here we use systems immunology approaches, including longitudinal multimodal single-cell analysis (surface proteins, transcriptome and V(D)J sequences) to comparatively assess baseline immune statuses and responses to influenza vaccination in 33 healthy individuals after recovery from mild, non-hospitalized COVID-19 (mean, 151 days after diagnosis) and 40 age- and sex-matched control individuals who had never had COVID-19. At the baseline and independent of time after COVID-19, recoverees had elevated T cell activation signatures and lower expression of innate immune genes including Toll-like receptors in monocytes. Male individuals who had recovered from COVID-19 had coordinately higher innate, influenza-specific plasmablast, and antibody responses after vaccination compared with healthy male individuals and female individuals who had recovered from COVID-19, in part because male recoverees had monocytes with higher IL-15 responses early after vaccination coupled with elevated prevaccination frequencies of 'virtual memory'-like CD8+ T cells poised to produce more IFNγ after IL-15 stimulation. Moreover, the expression of the repressed innate immune genes in monocytes increased by day 1 to day 28 after vaccination in recoverees, therefore moving towards the prevaccination baseline of the healthy control individuals. By contrast, these genes decreased on day 1 and returned to the baseline by day 28 in the control individuals. Our study reveals sex-dimorphic effects of previous mild COVID-19 and suggests that viral infections in humans can establish new immunological set-points that affect future immune responses in an antigen-agnostic manner." @default.
- W4313483818 created "2023-01-06" @default.
- W4313483818 creator A5000950209 @default.
- W4313483818 creator A5001669383 @default.
- W4313483818 creator A5004671892 @default.
- W4313483818 creator A5007316328 @default.
- W4313483818 creator A5007617765 @default.
- W4313483818 creator A5015292974 @default.
- W4313483818 creator A5015417610 @default.
- W4313483818 creator A5019096863 @default.
- W4313483818 creator A5020973283 @default.
- W4313483818 creator A5025869235 @default.
- W4313483818 creator A5030115420 @default.
- W4313483818 creator A5030496508 @default.
- W4313483818 creator A5030865384 @default.
- W4313483818 creator A5031895384 @default.
- W4313483818 creator A5036320447 @default.
- W4313483818 creator A5045197971 @default.
- W4313483818 creator A5045226464 @default.
- W4313483818 creator A5048338544 @default.
- W4313483818 creator A5050975581 @default.
- W4313483818 creator A5051638054 @default.
- W4313483818 creator A5055170129 @default.
- W4313483818 creator A5057459858 @default.
- W4313483818 creator A5058300486 @default.
- W4313483818 creator A5058739804 @default.
- W4313483818 creator A5058836905 @default.
- W4313483818 creator A5063383626 @default.
- W4313483818 creator A5063689575 @default.
- W4313483818 creator A5064349182 @default.
- W4313483818 creator A5071330243 @default.
- W4313483818 creator A5078288473 @default.
- W4313483818 creator A5079432854 @default.
- W4313483818 creator A5080101975 @default.
- W4313483818 creator A5085809326 @default.
- W4313483818 creator A5087235925 @default.
- W4313483818 creator A5090497477 @default.
- W4313483818 date "2023-01-04" @default.
- W4313483818 modified "2023-10-15" @default.
- W4313483818 title "Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19" @default.
- W4313483818 cites W1630221068 @default.
- W4313483818 cites W1859890325 @default.
- W4313483818 cites W1969218538 @default.
- W4313483818 cites W1978153508 @default.
- W4313483818 cites W1979424337 @default.
- W4313483818 cites W1993900061 @default.
- W4313483818 cites W1999277453 @default.
- W4313483818 cites W2010457001 @default.
- W4313483818 cites W2039521726 @default.
- W4313483818 cites W2049998759 @default.
- W4313483818 cites W2059980695 @default.
- W4313483818 cites W2062690397 @default.
- W4313483818 cites W2093274439 @default.
- W4313483818 cites W2107940314 @default.
- W4313483818 cites W2110065044 @default.
- W4313483818 cites W2118306668 @default.
- W4313483818 cites W2118362676 @default.
- W4313483818 cites W2130116522 @default.
- W4313483818 cites W2131271579 @default.
- W4313483818 cites W2137526110 @default.
- W4313483818 cites W2138207763 @default.
- W4313483818 cites W2146512944 @default.
- W4313483818 cites W2159707944 @default.
- W4313483818 cites W2160395304 @default.
- W4313483818 cites W2179438025 @default.
- W4313483818 cites W2345654247 @default.
- W4313483818 cites W2406250479 @default.
- W4313483818 cites W2518536270 @default.
- W4313483818 cites W2541841360 @default.
- W4313483818 cites W2613641182 @default.
- W4313483818 cites W2626120438 @default.
- W4313483818 cites W2644728868 @default.
- W4313483818 cites W2728919089 @default.
- W4313483818 cites W2739492614 @default.
- W4313483818 cites W2774307122 @default.
- W4313483818 cites W2900562404 @default.
- W4313483818 cites W2911922390 @default.
- W4313483818 cites W2944434778 @default.
- W4313483818 cites W2944948027 @default.
- W4313483818 cites W2949177718 @default.
- W4313483818 cites W2949836416 @default.
- W4313483818 cites W2951506174 @default.
- W4313483818 cites W2966564986 @default.
- W4313483818 cites W2982502551 @default.
- W4313483818 cites W3002623081 @default.
- W4313483818 cites W3007282081 @default.
- W4313483818 cites W3009920944 @default.
- W4313483818 cites W3012344676 @default.
- W4313483818 cites W3013039453 @default.
- W4313483818 cites W3015851459 @default.
- W4313483818 cites W3033295933 @default.
- W4313483818 cites W3039456903 @default.
- W4313483818 cites W3046454618 @default.
- W4313483818 cites W3047402958 @default.
- W4313483818 cites W3047880178 @default.
- W4313483818 cites W3080263813 @default.
- W4313483818 cites W3080487846 @default.
- W4313483818 cites W3107765474 @default.