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- W4313483836 abstract "The circadian system is composed of a subset of temporal oscillators that function through a transcriptional and post-translational molecular and functional negative feedback loop cycling approximately every 24 hours. The central clock located in the suprachiasmatic nucleus is responsible for entrainment using light as the key timekeeper (zeitgeber); it is responsible for synchronizing and optimizing physiological behavior and function to the environment. Exogenous information, such as day length and light-dark cycles, provide critical temporal cues for adjusting to environmental conditions. Proper alignment to natural light dark cycles and circadian rhythms is optimal for vital health, fitness, and survival in organisms. Although considered previously innocuous, exposure to nighttime lighting is becoming increasingly prevalent due to development and urbanization. This can disrupt time of day variations to environmental adaptations and current literature has demonstrated that light at night (LAN) substantially disrupts physiological function and behavior, dysregulates circadian organization of immune function, metabolism. Further, this is associated with increased cardiometabolic disease, cancer, and other significant health risks. Exposure to LAN is becoming more pervasive to modern life and environments, where over 80% globally, and up to 99% of the United States and European populations are exposed to nighttime lighting. Circadian disruption has been linked to poor disease outcome in cases such as stroke, sepsis, and global ischemia, and critically ill and compromised patients may be especially at risk and vulnerable to the detrimental impacts of nighttime light." @default.
- W4313483836 created "2023-01-06" @default.
- W4313483836 creator A5035767413 @default.
- W4313483836 date "2023-01-04" @default.
- W4313483836 modified "2023-09-28" @default.
- W4313483836 title "Influences of Disrupted Circadian Rhythms on Stroke Outcome" @default.
- W4313483836 doi "https://doi.org/10.33915/etd.11606" @default.
- W4313483836 hasPublicationYear "2023" @default.
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