Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313485055> ?p ?o ?g. }
- W4313485055 abstract "Abstract Background Rotator cuff (RC) tears are one of the most common shoulder disorders. The causes of RC tears include acute trauma and chronic impact injury. The clinical outcome of RC tears is not satisfactory because the pathogenesis of RC tears is not well understood. Therefore, the molecular mechanisms involved in RC tears need to be elucidated in order to develop clinical innovative therapies. Methods The mechanism of ferroptosis and inflammation involved in the development of RC tears was investigated and confirmed using a combination of bioinformatics methodology and in vivo experimental approaches. Results The Gene Expression Omnibus database was used to obtain the microarray data relevant to the RC tears for further investigation. In addition to carrying out function enrichment analysis, protein-protein correlation analysis, building the correlation regulatory network, and examining potential associations between ferroptosis and immune abnormalities and inflammatory responses in RC tears, a number of bioinformatic techniques were used to identify the ferroptosis-related genes. Last but not least, we created an RC tears rat model for in vivo experimental validation. This model was primarily based on histological analysis and the qPCR approach to assess the major correlation pairs in regulating ferroptosis and the inflammatory response in RC tears. For the additional function enrichment analysis, 10 hub ferroptosis-related genes were chosen to construct the correlation regulation network. In RC tears, it was discovered that genes related to hub ferroptosis and hub inflammatory response were strongly correlated. The outcomes of in vivo tests showed that RC tears were related to Cd68 - Cxcl13 , Acsl4 - Sat1 , Acsl3 - Eno3 , Acsl3 - Ccr7 , and Ccr7 - Eno3 pairings in regulating ferroptosis and inflammatory response. Conclusion The pairs Cd68-Cxcl13, Acsl4-Sat1, Acsl3-Eno3, Acsl3-Ccr7, and Ccr7-Eno3 were found to be connected to RC tears in regulating ferroptosis and the inflammatory response. Our results show an association between ferroptosis and inflammation, providing a new avenue to explore the clinical treatment of RC tears." @default.
- W4313485055 created "2023-01-06" @default.
- W4313485055 creator A5008249680 @default.
- W4313485055 creator A5027369479 @default.
- W4313485055 creator A5027704528 @default.
- W4313485055 creator A5046122394 @default.
- W4313485055 creator A5046706991 @default.
- W4313485055 creator A5062177057 @default.
- W4313485055 creator A5072670069 @default.
- W4313485055 creator A5084363318 @default.
- W4313485055 date "2023-01-04" @default.
- W4313485055 modified "2023-09-26" @default.
- W4313485055 title "Mechanisms of ferroptosis with immune infiltration and inflammatory response in rotator cuff injury" @default.
- W4313485055 cites W1863138831 @default.
- W4313485055 cites W1972571860 @default.
- W4313485055 cites W1975831811 @default.
- W4313485055 cites W1978269338 @default.
- W4313485055 cites W1981228003 @default.
- W4313485055 cites W1985987855 @default.
- W4313485055 cites W1991278770 @default.
- W4313485055 cites W1995949259 @default.
- W4313485055 cites W2010856745 @default.
- W4313485055 cites W2015412442 @default.
- W4313485055 cites W2045341555 @default.
- W4313485055 cites W2058334209 @default.
- W4313485055 cites W2068538815 @default.
- W4313485055 cites W2094914028 @default.
- W4313485055 cites W2103912979 @default.
- W4313485055 cites W2108723188 @default.
- W4313485055 cites W2112039060 @default.
- W4313485055 cites W2144067550 @default.
- W4313485055 cites W2151328705 @default.
- W4313485055 cites W2159675211 @default.
- W4313485055 cites W2537623931 @default.
- W4313485055 cites W2773549048 @default.
- W4313485055 cites W2774325855 @default.
- W4313485055 cites W2791758888 @default.
- W4313485055 cites W2799287501 @default.
- W4313485055 cites W2807134042 @default.
- W4313485055 cites W2948017193 @default.
- W4313485055 cites W2951506786 @default.
- W4313485055 cites W2963095670 @default.
- W4313485055 cites W3028234091 @default.
- W4313485055 cites W3041754841 @default.
- W4313485055 cites W3045738499 @default.
- W4313485055 cites W3096669046 @default.
- W4313485055 cites W3115773653 @default.
- W4313485055 cites W3118563385 @default.
- W4313485055 cites W3159365861 @default.
- W4313485055 cites W3171018860 @default.
- W4313485055 cites W4285592387 @default.
- W4313485055 cites W4300960565 @default.
- W4313485055 doi "https://doi.org/10.21203/rs.3.rs-2424316/v1" @default.
- W4313485055 hasPublicationYear "2023" @default.
- W4313485055 type Work @default.
- W4313485055 citedByCount "0" @default.
- W4313485055 crossrefType "posted-content" @default.
- W4313485055 hasAuthorship W4313485055A5008249680 @default.
- W4313485055 hasAuthorship W4313485055A5027369479 @default.
- W4313485055 hasAuthorship W4313485055A5027704528 @default.
- W4313485055 hasAuthorship W4313485055A5046122394 @default.
- W4313485055 hasAuthorship W4313485055A5046706991 @default.
- W4313485055 hasAuthorship W4313485055A5062177057 @default.
- W4313485055 hasAuthorship W4313485055A5072670069 @default.
- W4313485055 hasAuthorship W4313485055A5084363318 @default.
- W4313485055 hasConcept C104317684 @default.
- W4313485055 hasConcept C141071460 @default.
- W4313485055 hasConcept C150194340 @default.
- W4313485055 hasConcept C17991360 @default.
- W4313485055 hasConcept C186836561 @default.
- W4313485055 hasConcept C203014093 @default.
- W4313485055 hasConcept C207001950 @default.
- W4313485055 hasConcept C2776511800 @default.
- W4313485055 hasConcept C2776914184 @default.
- W4313485055 hasConcept C2778275304 @default.
- W4313485055 hasConcept C54355233 @default.
- W4313485055 hasConcept C71924100 @default.
- W4313485055 hasConcept C86803240 @default.
- W4313485055 hasConcept C8891405 @default.
- W4313485055 hasConceptScore W4313485055C104317684 @default.
- W4313485055 hasConceptScore W4313485055C141071460 @default.
- W4313485055 hasConceptScore W4313485055C150194340 @default.
- W4313485055 hasConceptScore W4313485055C17991360 @default.
- W4313485055 hasConceptScore W4313485055C186836561 @default.
- W4313485055 hasConceptScore W4313485055C203014093 @default.
- W4313485055 hasConceptScore W4313485055C207001950 @default.
- W4313485055 hasConceptScore W4313485055C2776511800 @default.
- W4313485055 hasConceptScore W4313485055C2776914184 @default.
- W4313485055 hasConceptScore W4313485055C2778275304 @default.
- W4313485055 hasConceptScore W4313485055C54355233 @default.
- W4313485055 hasConceptScore W4313485055C71924100 @default.
- W4313485055 hasConceptScore W4313485055C86803240 @default.
- W4313485055 hasConceptScore W4313485055C8891405 @default.
- W4313485055 hasLocation W43134850551 @default.
- W4313485055 hasOpenAccess W4313485055 @default.
- W4313485055 hasPrimaryLocation W43134850551 @default.
- W4313485055 hasRelatedWork W1983371565 @default.
- W4313485055 hasRelatedWork W198564910 @default.
- W4313485055 hasRelatedWork W2003736806 @default.
- W4313485055 hasRelatedWork W2075593810 @default.