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• W4313485095 abstract "How the growth rate of a microbial population responds to the environmental availability of chemical nutrients and other resources is a fundamental question in microbiology. Models of this response, such as the widely used Monod model, are generally characterized by a maximum growth rate and a half-saturation concentration of the resource. What values should we expect for these half-saturation concentrations, and how should they depend on the environmental concentration of the resource? We survey growth response data across a wide range of organisms and resources. We find that the half-saturation concentrations vary across orders of magnitude, even for the same organism and resource. To explain this variation, we develop an evolutionary model to show that demographic fluctuations (genetic drift) can constrain the adaptation of half-saturation concentrations. We find that this effect fundamentally differs depending on the type of population dynamics: Populations undergoing periodic bottlenecks of fixed size will adapt their half-saturation concentrations in proportion to the environmental resource concentrations, but populations undergoing periodic dilutions of fixed size will evolve half-saturation concentrations that are largely decoupled from the environmental concentrations. Our model not only provides testable predictions for laboratory evolution experiments, but it also reveals how an evolved half-saturation concentration may not reflect the organism’s environment. In particular, this explains how organisms in resource-rich environments can still evolve fast growth at low resource concentrations. Altogether, our results demonstrate the critical role of population dynamics in shaping fundamental ecological traits." @default.
• W4313485095 created "2023-01-06" @default.
• W4313485095 creator A5056958220 @default.
• W4313485095 creator A5070974187 @default.
• W4313485095 creator A5089627775 @default.
• W4313485095 date "2023-01-04" @default.
• W4313485095 modified "2023-10-12" @default.
• W4313485095 title "Microbial population dynamics decouple growth response from environmental nutrient concentration" @default.
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• W4313485095 doi "https://doi.org/10.1073/pnas.2207295120" @default.
• W4313485095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36598949" @default.
• W4313485095 hasPublicationYear "2023" @default.
• W4313485095 type Work @default.
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• W4313485095 hasAuthorship W4313485095A5056958220 @default.
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• W4313485095 hasAuthorship W4313485095A5089627775 @default.
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