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• W4313487112 abstract "Abstract In response to the COVID-19 pandemic, different types of vaccines, such as inactive, live-attenuated, messenger RNA, and protein subunit, have been developed against SARS-CoV2. This circumstance has unintentionally led to heterologous prime-boost vaccination against a single virus in a large human population. Here, we aimed to analyze whether the immunization order of vaccine types influences the efficacy of heterologous prime-boost vaccination, especially mRNA and protein-based vaccines. We developed a new mRNA vaccine expressing hemagglutinin (HA) of influenza using the 3′UTR and 5′UTR of muscle cells (mRNA-HA) and tested its efficacy by heterologous immunization with an HA protein vaccine (protein-HA). The results demonstrated higher IgG2a levels and hemagglutination inhibition titers in mRNA-HA priming/protein-HA boosting (R-P) regimen than that induced by reverse immunization (protein-HA priming/mRNA-HA boosting, P-R). After the virus challenge, the R-P group showed lower virus titers and less inflammation in the lungs than the P-R group. Transcriptome analysis revealed that heterologous prime-boost groups had differentially activated immune response pathways, according to the order of immunization. In summary, our results demonstrate that the sequence of vaccination is critical to sculpt immune responses. This study provides the potential of a heterologous vaccination strategy using mRNA and protein vaccine platforms against viral infection." @default.
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• W4313487112 date "2023-01-04" @default.
• W4313487112 modified "2023-09-27" @default.
• W4313487112 title "Analysis of vaccine-induced immune responses according to the immunization sequences of mRNA and protein vaccines" @default.
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• W4313487112 doi "https://doi.org/10.21203/rs.3.rs-2361251/v1" @default.
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