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- W4313487510 endingPage "137748" @default.
- W4313487510 startingPage "137748" @default.
- W4313487510 abstract "In vivo, in vitro, and epidemiological evidence suggests that perfluoroalkyl substances (PFAS) may alter thyroid function in human health, with negative effects on maternal and fetal development outcomes. However, data on the effects of PFAS on thyroid hormones remain controversial. Here, we conducted a meta-analysis of 13 eligible studies searched from Embase, PubMed, and Web of Science by July 10, 2022, to explore the relationship between maternal exposure to PFAS and thyroid health effects, including thyroid stimulating hormone (TSH), triiodothyronine (TT3), thyroxin (TT4), free T3 (FT3), and free T4 (FT4). The estimated values (β) and the corresponding confidence intervals (95%CI) were extracted for analysis. The tests for heterogeneity, sensitivity and publication bias between studies were performed using Stata 15.0. The combined results showed a positive association between changes in TSH and exposure to perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA), with no significant correlation observed between changes in other thyroid hormones and exposure to PFAS. This difference was attributed to sample size, region, sample type, body mass index (BMI), and gestational week. Our data recommend verifying the relationship between PFAS exposure and thyroid health effects in a large sample population cohort in future studies. In addition, health care should be taken into account in early and mid-pregnancy." @default.
- W4313487510 created "2023-01-06" @default.
- W4313487510 creator A5016285103 @default.
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- W4313487510 creator A5071798264 @default.
- W4313487510 date "2023-02-01" @default.
- W4313487510 modified "2023-10-16" @default.
- W4313487510 title "Contact to perfluoroalkyl substances and thyroid health effects: A meta-analysis directing on pregnancy" @default.
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- W4313487510 doi "https://doi.org/10.1016/j.chemosphere.2023.137748" @default.
- W4313487510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36610509" @default.
- W4313487510 hasPublicationYear "2023" @default.
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