FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313487536> ?p ?o ?g. }

• W4313487536 endingPage "107014" @default.
• W4313487536 startingPage "107014" @default.
• W4313487536 abstract "Snake venoms are a complex mixture of proteins and peptides that can activate/inhibit platelet aggregation. Bothrops alternatus venom include three main families: metalloproteinases (SVMPs), serinoproteinases (SVSPs) and phospholipases A2 (PLA2s), among other minor components. In this work, we used inhibitor cocktails (containing Na2-EDTA, PMSF and/or pBPB) to investigate the effect of these three families and of baltergin (a PIII SVMP) on platelet aggregation by a turbidmetric method using a microplate reader. Cocktails 1 (active SVMPs) and 2 (active PLA2s) significantly reduced aggregation induced by ristocetin and collagen and by collagen and thrombin, respectively. Cocktail 3 (active SVSPs) showed a mild activation of aggregation, indicating the content of thrombin-like enzymes (TLEs) in this venom is low. Cocktail 4 (active minor components) displayed inhibitory effect with all agonists assayed (ristocetin, ADP, collagen and thrombin) but at higher IC50 values. Baltergin exhibited inhibitory effect when the catalytic domain was active for ristocetin-stimulated platelet aggregation and showed a non-enzymatic mechanism of inhibition when collagen was used as agonist. It was not able to disaggregate platelet thrombus. We conclude that B. alternatus venom is a source of natural inhibitors of platelet aggregation due to the action of SVMPs and PLA2s. Other minor components such as C-type lectins likely contribute to the antiplatelet effect. The interest in knowing the action of venom components on platelet function lies both in the understanding of the pathophysiology of snake bite envenomation and in their biotechnological application." @default.
• W4313487536 created "2023-01-06" @default.
• W4313487536 creator A5005467784 @default.
• W4313487536 creator A5008906734 @default.
• W4313487536 creator A5017550653 @default.
• W4313487536 creator A5021535017 @default.
• W4313487536 creator A5048892672 @default.
• W4313487536 creator A5071677556 @default.
• W4313487536 creator A5084401756 @default.
• W4313487536 date "2023-02-01" @default.
• W4313487536 modified "2023-10-06" @default.
• W4313487536 title "Platelet aggregation inhibitors from Bothrops alternatus snake venom" @default.
• W4313487536 cites W138546028 @default.
• W4313487536 cites W1538333669 @default.
• W4313487536 cites W1871618339 @default.
• W4313487536 cites W1939750459 @default.
• W4313487536 cites W1965520907 @default.
• W4313487536 cites W1966497279 @default.
• W4313487536 cites W1972970439 @default.
• W4313487536 cites W1984501891 @default.
• W4313487536 cites W1990030076 @default.
• W4313487536 cites W1995520384 @default.
• W4313487536 cites W2001200650 @default.
• W4313487536 cites W2020914789 @default.
• W4313487536 cites W2028590427 @default.
• W4313487536 cites W2034956882 @default.
• W4313487536 cites W2037439512 @default.
• W4313487536 cites W2043383369 @default.
• W4313487536 cites W2052731599 @default.
• W4313487536 cites W2053523671 @default.
• W4313487536 cites W2062420086 @default.
• W4313487536 cites W2072764202 @default.
• W4313487536 cites W2075477360 @default.
• W4313487536 cites W2077999468 @default.
• W4313487536 cites W2080994303 @default.
• W4313487536 cites W2085232594 @default.
• W4313487536 cites W2094001578 @default.
• W4313487536 cites W2095345326 @default.
• W4313487536 cites W2100946608 @default.
• W4313487536 cites W2208861868 @default.
• W4313487536 cites W2322660019 @default.
• W4313487536 cites W2606625770 @default.
• W4313487536 cites W2757432965 @default.
• W4313487536 cites W2789677262 @default.
• W4313487536 cites W2951973322 @default.
• W4313487536 cites W4293247451 @default.
• W4313487536 cites W80085826 @default.
• W4313487536 doi "https://doi.org/10.1016/j.toxicon.2022.107014" @default.
• W4313487536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36610603" @default.
• W4313487536 hasPublicationYear "2023" @default.
• W4313487536 type Work @default.
• W4313487536 citedByCount "0" @default.
• W4313487536 crossrefType "journal-article" @default.
• W4313487536 hasAuthorship W4313487536A5005467784 @default.
• W4313487536 hasAuthorship W4313487536A5008906734 @default.
• W4313487536 hasAuthorship W4313487536A5017550653 @default.
• W4313487536 hasAuthorship W4313487536A5021535017 @default.
• W4313487536 hasAuthorship W4313487536A5048892672 @default.
• W4313487536 hasAuthorship W4313487536A5071677556 @default.
• W4313487536 hasAuthorship W4313487536A5084401756 @default.
• W4313487536 hasConcept C117287731 @default.
• W4313487536 hasConcept C145600735 @default.
• W4313487536 hasConcept C185592680 @default.
• W4313487536 hasConcept C203014093 @default.
• W4313487536 hasConcept C2776057759 @default.
• W4313487536 hasConcept C2776725428 @default.
• W4313487536 hasConcept C2777292125 @default.
• W4313487536 hasConcept C2779231127 @default.
• W4313487536 hasConcept C2779394231 @default.
• W4313487536 hasConcept C2779448229 @default.
• W4313487536 hasConcept C2779815518 @default.
• W4313487536 hasConcept C55493867 @default.
• W4313487536 hasConcept C86803240 @default.
• W4313487536 hasConcept C89560881 @default.
• W4313487536 hasConcept C98274493 @default.
• W4313487536 hasConceptScore W4313487536C117287731 @default.
• W4313487536 hasConceptScore W4313487536C145600735 @default.
• W4313487536 hasConceptScore W4313487536C185592680 @default.
• W4313487536 hasConceptScore W4313487536C203014093 @default.
• W4313487536 hasConceptScore W4313487536C2776057759 @default.
• W4313487536 hasConceptScore W4313487536C2776725428 @default.
• W4313487536 hasConceptScore W4313487536C2777292125 @default.
• W4313487536 hasConceptScore W4313487536C2779231127 @default.
• W4313487536 hasConceptScore W4313487536C2779394231 @default.
• W4313487536 hasConceptScore W4313487536C2779448229 @default.
• W4313487536 hasConceptScore W4313487536C2779815518 @default.
• W4313487536 hasConceptScore W4313487536C55493867 @default.
• W4313487536 hasConceptScore W4313487536C86803240 @default.
• W4313487536 hasConceptScore W4313487536C89560881 @default.
• W4313487536 hasConceptScore W4313487536C98274493 @default.
• W4313487536 hasLocation W43134875361 @default.
• W4313487536 hasLocation W43134875362 @default.
• W4313487536 hasOpenAccess W4313487536 @default.
• W4313487536 hasPrimaryLocation W43134875361 @default.
• W4313487536 hasRelatedWork W1501816728 @default.
• W4313487536 hasRelatedWork W1604512593 @default.
• W4313487536 hasRelatedWork W2109863777 @default.
• W4313487536 hasRelatedWork W2114015583 @default.

• next