Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313487641> ?p ?o ?g. }
- W4313487641 endingPage "24" @default.
- W4313487641 startingPage "7" @default.
- W4313487641 abstract "Abstract Cardiometabolic disorders (CMD) is a constellation of metabolic predisposing factors for atherosclerosis such as insulin resistance (IR) or diabetes mellitus (DM), systemic hypertension, central obesity, and dyslipidemia. Cardiometabolic diseases (CMDs) continue to be the leading cause of mortality in both developed and developing nations, accounting for over 32% of all fatalities globally each year. Furthermore, dyslipidemia, angina, arrhythmia, heart failure, myocardial infarction (MI), and diabetes mellitus are the major causes of death, accounting for an estimated 19 million deaths in 2012. CVDs will kill more than 23 million individuals each year by 2030. Nonetheless, new drug development (NDD) in CMDs has been increasingly difficult in recent decades due to increased costs and a lower success rate. Drug repositioning in CMDs looks promising in this scenario for launching current medicines for new therapeutic indications. Repositioning is an ancient method that dates back to the 1960s and is mostly based on coincidental findings during medication trials. One significant advantage of repositioning is that the drug’s safety profile is well known, lowering the odds of failure owing to undesirable toxic effects. Furthermore, repositioning takes less time and money than NDD. Given these facts, pharmaceutical corporations are becoming more interested in medication repositioning. In this follow-up, we discussed the notion of repositioning and provided some examples of repositioned medications in cardiometabolic disorders." @default.
- W4313487641 created "2023-01-06" @default.
- W4313487641 creator A5005656921 @default.
- W4313487641 creator A5009691290 @default.
- W4313487641 creator A5018489790 @default.
- W4313487641 creator A5031202475 @default.
- W4313487641 creator A5046390054 @default.
- W4313487641 creator A5054964703 @default.
- W4313487641 creator A5065336510 @default.
- W4313487641 creator A5071061237 @default.
- W4313487641 creator A5073894344 @default.
- W4313487641 creator A5084814033 @default.
- W4313487641 date "2023-01-01" @default.
- W4313487641 modified "2023-10-16" @default.
- W4313487641 title "Repurposing of Drugs for Cardiometabolic Disorders: An Out and Out Cumulation" @default.
- W4313487641 cites W1573357728 @default.
- W4313487641 cites W1577747457 @default.
- W4313487641 cites W169333368 @default.
- W4313487641 cites W1835212113 @default.
- W4313487641 cites W1935617463 @default.
- W4313487641 cites W1963557257 @default.
- W4313487641 cites W1966379378 @default.
- W4313487641 cites W1968217711 @default.
- W4313487641 cites W1968315455 @default.
- W4313487641 cites W1968607405 @default.
- W4313487641 cites W1969068062 @default.
- W4313487641 cites W1972537175 @default.
- W4313487641 cites W1973442218 @default.
- W4313487641 cites W1973901069 @default.
- W4313487641 cites W1974667156 @default.
- W4313487641 cites W1976509021 @default.
- W4313487641 cites W1981715547 @default.
- W4313487641 cites W1983883248 @default.
- W4313487641 cites W1984467425 @default.
- W4313487641 cites W1985592156 @default.
- W4313487641 cites W1987349557 @default.
- W4313487641 cites W1993252135 @default.
- W4313487641 cites W1996063176 @default.
- W4313487641 cites W1997393323 @default.
- W4313487641 cites W2002419343 @default.
- W4313487641 cites W2004830232 @default.
- W4313487641 cites W2005140805 @default.
- W4313487641 cites W2005230361 @default.
- W4313487641 cites W2006922237 @default.
- W4313487641 cites W2008731781 @default.
- W4313487641 cites W2015278347 @default.
- W4313487641 cites W2021654494 @default.
- W4313487641 cites W2028279539 @default.
- W4313487641 cites W2030270894 @default.
- W4313487641 cites W2030562170 @default.
- W4313487641 cites W2030843949 @default.
- W4313487641 cites W2032947201 @default.
- W4313487641 cites W2033746319 @default.
- W4313487641 cites W2034370234 @default.
- W4313487641 cites W2036385867 @default.
- W4313487641 cites W2039702671 @default.
- W4313487641 cites W2044967663 @default.
- W4313487641 cites W2046189497 @default.
- W4313487641 cites W2049995317 @default.
- W4313487641 cites W2050875709 @default.
- W4313487641 cites W2051298109 @default.
- W4313487641 cites W2052301782 @default.
- W4313487641 cites W2055611619 @default.
- W4313487641 cites W2057615392 @default.
- W4313487641 cites W2058563527 @default.
- W4313487641 cites W2062941476 @default.
- W4313487641 cites W2063400466 @default.
- W4313487641 cites W2063818338 @default.
- W4313487641 cites W2065372294 @default.
- W4313487641 cites W2065789765 @default.
- W4313487641 cites W2070768644 @default.
- W4313487641 cites W2073192039 @default.
- W4313487641 cites W2078570369 @default.
- W4313487641 cites W2078727668 @default.
- W4313487641 cites W2080255605 @default.
- W4313487641 cites W2082761367 @default.
- W4313487641 cites W2086200071 @default.
- W4313487641 cites W2086567283 @default.
- W4313487641 cites W2087613795 @default.
- W4313487641 cites W2087955095 @default.
- W4313487641 cites W2090360729 @default.
- W4313487641 cites W2092833954 @default.
- W4313487641 cites W2093179187 @default.
- W4313487641 cites W2093313266 @default.
- W4313487641 cites W2093614281 @default.
- W4313487641 cites W2096335789 @default.
- W4313487641 cites W2099670937 @default.
- W4313487641 cites W2105554519 @default.
- W4313487641 cites W2109677274 @default.
- W4313487641 cites W2113094401 @default.
- W4313487641 cites W2113983413 @default.
- W4313487641 cites W2116831537 @default.
- W4313487641 cites W2123319002 @default.
- W4313487641 cites W2124160215 @default.
- W4313487641 cites W2129551734 @default.
- W4313487641 cites W2133533488 @default.
- W4313487641 cites W2135009079 @default.
- W4313487641 cites W2137218308 @default.