FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313487839> ?p ?o ?g. }

• W4313487839 endingPage "17" @default.
• W4313487839 startingPage "1" @default.
• W4313487839 abstract "Diabetes is a chronic metabolic disorder marked by postprandial hyperglycemia due to several etiologies including abnormal carbohydrate digestion and glycation of hemoglobin. The prolong use of synthetic drugs results in characteristic side effects which necessitates the discovery of safe and cost-effective substitutes. The aim of the current study is to isolate and evaluate the antidiabetic potential of the phenolic compounds from the leaves of Tradescantia pallida. Syringic acid, p-coumaric acid, morin and catechin (compounds 1-4) were isolated and characterized from Tradescantia pallida leaves using column chromatography and spectroscopic techniques. The in vitro antidiabetic potential of the phenolic compounds were assessed using α-amylase and non-enzymatic glycosylation of hemoglobin protein assays. A mechanistic insight of interactions between phenolic compounds and human α-amylase and hemoglobin protein were scrutinized by employing molecular docking method. Prime Molecular Mechanics/Generalized Born Surface Area (MM-GBSA) calculations were carried out to find the binding energies of the ligand-protein complexes. Morin and catechin were further analyzed to find the dynamic and thermodynamic constraints of the complexes under specific biological conditions using molecular dynamic simulation trajectories. The stability and flexibility of the complexes were justified by fluctuation of α-carbon chain, Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF) and type of interactions involved which authenticated the in vitro inhibitory potential of morin and catechin against enzymatic and non-enzymatic pathways. The current study could be fruitful in rational designing of safe antidiabetic drugs of natural origin.Communicated by Ramaswamy H. Sarma." @default.
• W4313487839 created "2023-01-06" @default.
• W4313487839 creator A5014210739 @default.
• W4313487839 creator A5016291114 @default.
• W4313487839 creator A5035855082 @default.
• W4313487839 creator A5073308410 @default.
• W4313487839 date "2023-01-04" @default.
• W4313487839 modified "2023-10-10" @default.
• W4313487839 title "Phenolic compounds from <i>Tradescantia pallida</i> ameliorate diabetes by inhibiting enzymatic and non-enzymatic pathways" @default.
• W4313487839 cites W1637147801 @default.
• W4313487839 cites W1860649260 @default.
• W4313487839 cites W1969594076 @default.
• W4313487839 cites W1972758026 @default.
• W4313487839 cites W1991025907 @default.
• W4313487839 cites W1991794210 @default.
• W4313487839 cites W1994149233 @default.
• W4313487839 cites W2004182866 @default.
• W4313487839 cites W2005875349 @default.
• W4313487839 cites W2023536393 @default.
• W4313487839 cites W2039219549 @default.
• W4313487839 cites W2043969520 @default.
• W4313487839 cites W2053174787 @default.
• W4313487839 cites W2058287541 @default.
• W4313487839 cites W2059789790 @default.
• W4313487839 cites W2063822338 @default.
• W4313487839 cites W2065815743 @default.
• W4313487839 cites W2068388923 @default.
• W4313487839 cites W2079174719 @default.
• W4313487839 cites W2094726623 @default.
• W4313487839 cites W2095719702 @default.
• W4313487839 cites W2103145453 @default.
• W4313487839 cites W2103397106 @default.
• W4313487839 cites W2103593741 @default.
• W4313487839 cites W2104478003 @default.
• W4313487839 cites W2129133439 @default.
• W4313487839 cites W2153338729 @default.
• W4313487839 cites W2154650052 @default.
• W4313487839 cites W2222589778 @default.
• W4313487839 cites W2462813263 @default.
• W4313487839 cites W2516762108 @default.
• W4313487839 cites W2522951514 @default.
• W4313487839 cites W2597582142 @default.
• W4313487839 cites W2620981436 @default.
• W4313487839 cites W2738714166 @default.
• W4313487839 cites W2789884447 @default.
• W4313487839 cites W2883292758 @default.
• W4313487839 cites W2885308748 @default.
• W4313487839 cites W2888459204 @default.
• W4313487839 cites W2894233472 @default.
• W4313487839 cites W2895046785 @default.
• W4313487839 cites W2898462909 @default.
• W4313487839 cites W2905438995 @default.
• W4313487839 cites W2912007829 @default.
• W4313487839 cites W2954094311 @default.
• W4313487839 cites W2971148593 @default.
• W4313487839 cites W2972222556 @default.
• W4313487839 cites W3003765589 @default.
• W4313487839 cites W3005890700 @default.
• W4313487839 cites W3012829982 @default.
• W4313487839 cites W3013100798 @default.
• W4313487839 cites W3025110670 @default.
• W4313487839 cites W3033153447 @default.
• W4313487839 cites W3036725561 @default.
• W4313487839 cites W3037320348 @default.
• W4313487839 cites W3046227393 @default.
• W4313487839 cites W3047169666 @default.
• W4313487839 cites W3131262417 @default.
• W4313487839 cites W3186955845 @default.
• W4313487839 cites W4200026682 @default.
• W4313487839 cites W4200055430 @default.
• W4313487839 cites W4200310486 @default.
• W4313487839 cites W4237523698 @default.
• W4313487839 cites W4281780639 @default.
• W4313487839 cites W4284961083 @default.
• W4313487839 cites W4310039561 @default.
• W4313487839 doi "https://doi.org/10.1080/07391102.2022.2164059" @default.
• W4313487839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36597930" @default.
• W4313487839 hasPublicationYear "2023" @default.
• W4313487839 type Work @default.
• W4313487839 citedByCount "2" @default.
• W4313487839 countsByYear W43134878392023 @default.
• W4313487839 crossrefType "journal-article" @default.
• W4313487839 hasAuthorship W4313487839A5014210739 @default.
• W4313487839 hasAuthorship W4313487839A5016291114 @default.
• W4313487839 hasAuthorship W4313487839A5035855082 @default.
• W4313487839 hasAuthorship W4313487839A5073308410 @default.
• W4313487839 hasConcept C142724271 @default.
• W4313487839 hasConcept C147990577 @default.
• W4313487839 hasConcept C170493617 @default.
• W4313487839 hasConcept C181199279 @default.
• W4313487839 hasConcept C185592680 @default.
• W4313487839 hasConcept C2776439734 @default.
• W4313487839 hasConcept C2778004101 @default.
• W4313487839 hasConcept C2779431889 @default.
• W4313487839 hasConcept C2779968248 @default.
• W4313487839 hasConcept C55493867 @default.
• W4313487839 hasConcept C70899900 @default.
• W4313487839 hasConcept C71924100 @default.

• next