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- W4313487870 abstract "Abstract Cancer survival and progression depend on the ability of tumor cells to avoid immune recognition. Advances in the understanding of cancer immunity and tumor immune escape mechanisms enabled the development of immunotherapeutic approaches. In patients with otherwise incurable metastatic cancers, immunotherapy resulted in unprecedented response rates with the potential for durable complete responses. However, primary and acquired resistance mechanisms limit the efficacy of immunotherapy. Further therapeutic advances require a deeper understanding of the interplay between immune cells and tumors. Most high-throughput studies within the past decade focused on an omics characterization at DNA and RNA level. However, proteins are the molecular effectors of genomic information; therefore, the study of proteins provides deeper understanding of cellular functions. Recent advances in mass spectrometry (MS)-based proteomics at a system-wide scale may allow translational and clinical discoveries by enabling the analysis of understudied post-translational modifications, subcellular protein localization, cell signaling, and protein–protein interactions. In this review, we discuss the potential contribution of MS-based proteomics to preclinical and clinical research findings in the context of tumor immunity and cancer immunotherapies." @default.
- W4313487870 created "2023-01-06" @default.
- W4313487870 creator A5022581366 @default.
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- W4313487870 creator A5045150333 @default.
- W4313487870 creator A5046276741 @default.
- W4313487870 creator A5057488386 @default.
- W4313487870 date "2023-01-04" @default.
- W4313487870 modified "2023-10-15" @default.
- W4313487870 title "Proteomics to study cancer immunity and improve treatment" @default.
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