FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313487930> ?p ?o ?g. }

• W4313487930 endingPage "2629" @default.
• W4313487930 startingPage "2617" @default.
• W4313487930 abstract "The fibrillization and deposition of the human islet amyloid polypeptide (hIAPP) are the pathological hallmark of type 2 diabetes mellitus (T2DM), and these insoluble fibrotic depositions of hIAPP are considered to strongly affect insulin secretion by inducing toxicity toward pancreatic islet β-cells. The current strategy of preventing amyloid aggregation by nanoparticle-assisted inhibitors can only disassemble fibrotic amyloids into more toxic oligomers and/or protofibrils. Herein, for the first time, we propose a type of cysteine-derived chiral carbon quantum dot (CQD) that targets plasmin, a core natural fibrinolytic protease in humans. These CQDs can serve as fibrinolytic activity regulators for plasmin to cleave hIAPP into nontoxic polypeptides or into even smaller amino acid fragments, thus alleviating hIAPP’s fibrotic amyloid-induced cytotoxicity. Our experiments indicate that chiral CQDs have opposing effects on plasmin activity. The l-CQDs promote the cleavage of hIAPP by enhancing plasmin activity at a promotion ratio of 23.2%, thus protecting β-cells from amyloid-induced toxicity. In contrast, the resultant d-CQDs significantly inhibit proteolysis, decreasing plasmin activity by 31.5% under the same reaction conditions. Second harmonic generation (SHG) microscopic imaging is initially used to dynamically characterize hIAPP before and after proteolysis. The l-CQD promotion of plasmin activity thus provides a promising avenue for the hIAPP-targeted treatment of T2DM to treat low fibrinolytic activity, while the d-CQDs, as inhibitors of plasmin activity, may improve patient survival for hyperfibrinolytic conditions, such as those existing during surgeries and traumas." @default.
• W4313487930 created "2023-01-06" @default.
• W4313487930 creator A5002018518 @default.
• W4313487930 creator A5004802154 @default.
• W4313487930 creator A5026066382 @default.
• W4313487930 creator A5058048748 @default.
• W4313487930 creator A5065243448 @default.
• W4313487930 creator A5070059518 @default.
• W4313487930 creator A5088664989 @default.
• W4313487930 date "2023-01-03" @default.
• W4313487930 modified "2023-10-16" @default.
• W4313487930 title "Cysteine-Derived Chiral Carbon Quantum Dots: A Fibrinolytic Activity Regulator for Plasmin to Target the Human Islet Amyloid Polypeptide for Type 2 Diabetes Mellitus" @default.
• W4313487930 cites W1887477306 @default.
• W4313487930 cites W1993548467 @default.
• W4313487930 cites W1995388090 @default.
• W4313487930 cites W1997347054 @default.
• W4313487930 cites W2012721217 @default.
• W4313487930 cites W2024941512 @default.
• W4313487930 cites W2026727321 @default.
• W4313487930 cites W2047816702 @default.
• W4313487930 cites W2052419530 @default.
• W4313487930 cites W2053669884 @default.
• W4313487930 cites W2064682352 @default.
• W4313487930 cites W2072002791 @default.
• W4313487930 cites W2075705506 @default.
• W4313487930 cites W2089218123 @default.
• W4313487930 cites W2091293942 @default.
• W4313487930 cites W2113115394 @default.
• W4313487930 cites W2162974554 @default.
• W4313487930 cites W2164187654 @default.
• W4313487930 cites W2170552507 @default.
• W4313487930 cites W2309593741 @default.
• W4313487930 cites W2334002376 @default.
• W4313487930 cites W2339965549 @default.
• W4313487930 cites W2404671794 @default.
• W4313487930 cites W2407144023 @default.
• W4313487930 cites W2414781026 @default.
• W4313487930 cites W2523470124 @default.
• W4313487930 cites W2532190852 @default.
• W4313487930 cites W2574347556 @default.
• W4313487930 cites W2599244054 @default.
• W4313487930 cites W2795953711 @default.
• W4313487930 cites W2805074648 @default.
• W4313487930 cites W2809540449 @default.
• W4313487930 cites W2846468914 @default.
• W4313487930 cites W2904129075 @default.
• W4313487930 cites W2916676406 @default.
• W4313487930 cites W2936936355 @default.
• W4313487930 cites W2944574613 @default.
• W4313487930 cites W2954568549 @default.
• W4313487930 cites W2955076562 @default.
• W4313487930 cites W2963040265 @default.
• W4313487930 cites W2995878473 @default.
• W4313487930 cites W3000379363 @default.
• W4313487930 cites W3013449264 @default.
• W4313487930 cites W3080278350 @default.
• W4313487930 cites W3084716063 @default.
• W4313487930 cites W3084854026 @default.
• W4313487930 cites W3105146261 @default.
• W4313487930 cites W3138386527 @default.
• W4313487930 cites W3143552619 @default.
• W4313487930 cites W3154855081 @default.
• W4313487930 cites W3185388140 @default.
• W4313487930 cites W3207620315 @default.
• W4313487930 cites W3212975416 @default.
• W4313487930 cites W4246436303 @default.
• W4313487930 doi "https://doi.org/10.1021/acsami.2c17975" @default.
• W4313487930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36596222" @default.
• W4313487930 hasPublicationYear "2023" @default.
• W4313487930 type Work @default.
• W4313487930 citedByCount "3" @default.
• W4313487930 countsByYear W43134879302023 @default.
• W4313487930 crossrefType "journal-article" @default.
• W4313487930 hasAuthorship W4313487930A5002018518 @default.
• W4313487930 hasAuthorship W4313487930A5004802154 @default.
• W4313487930 hasAuthorship W4313487930A5026066382 @default.
• W4313487930 hasAuthorship W4313487930A5058048748 @default.
• W4313487930 hasAuthorship W4313487930A5065243448 @default.
• W4313487930 hasAuthorship W4313487930A5070059518 @default.
• W4313487930 hasAuthorship W4313487930A5088664989 @default.
• W4313487930 hasConcept C12554922 @default.
• W4313487930 hasConcept C134018914 @default.
• W4313487930 hasConcept C165220095 @default.
• W4313487930 hasConcept C179104552 @default.
• W4313487930 hasConcept C181199279 @default.
• W4313487930 hasConcept C185592680 @default.
• W4313487930 hasConcept C2777633098 @default.
• W4313487930 hasConcept C2779201268 @default.
• W4313487930 hasConcept C2779281246 @default.
• W4313487930 hasConcept C2779306644 @default.
• W4313487930 hasConcept C2781071845 @default.
• W4313487930 hasConcept C2781307694 @default.
• W4313487930 hasConcept C49039625 @default.
• W4313487930 hasConcept C55493867 @default.
• W4313487930 hasConcept C86803240 @default.
• W4313487930 hasConcept C95444343 @default.
• W4313487930 hasConceptScore W4313487930C12554922 @default.
• W4313487930 hasConceptScore W4313487930C134018914 @default.

• next