Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313487943> ?p ?o ?g. }
- W4313487943 endingPage "1030" @default.
- W4313487943 startingPage "1019" @default.
- W4313487943 abstract "Sepsis-associated encephalopathy (SAE), a neurological dysfunction caused by sepsis, is the most common complication among septic ICU patients. Given the major role of inflammation in the pathophysiology of sepsis-induced anxiety, an extreme and early manifestation of SAE, the present study examined whether tannic acid, as an anti-inflammatory agent, has anxiolytic effects in cecal ligation and puncture (CLP)-induced sepsis. Forty male Wistar rats were assigned to four groups: (1) sham; (2) sham + tannic acid; (3) sepsis and (4) sepsis + tannic acid. Sepsis was induced by cecal ligation and puncture model. Animals in the sham + tannic acid and sepsis + tannic acid groups received tannic acid (20 mg/kg, i.p.), 6, 12, and 18 h after the sepsis induction. Twenty-four hours after the sepsis induction, systolic blood pressure and sepsis score were assessed. Anxiety-related behaviors were evaluated using elevated plus-maze and dark–light transition tests. Moreover, inflammatory markers (TNF-α and IL-6) and oxidative stress parameters (MDA and SOD) were measured in the brain tissue while protein levels (GABAA receptors and IL-1β) were assessed in the hippocampus. Administration of tannic acid significantly improved sepsis score and hypotension induced by sepsis. Anxiety-related behaviors showed a significant decrease in the sepsis + tannic acid group compared to the sepsis group. Tannic acid caused a significant decrease in the brain inflammatory markers and a remarkable improvement in the brain oxidative status compared to the septic rats. Tannic acid prevented animals from decreasing GABAA receptors and increasing IL-1β protein levels in the hippocampus compared to the sepsis group. This study indicated that tannic acid mitigated anxiety-related behaviors through decreasing inflammation and oxidative stress and positively modifying IL-1β/GABAA receptor pathway. Therefore, tannic acid shows promise as an efficacious treatment for comorbid anxiety in septic patients." @default.
- W4313487943 created "2023-01-06" @default.
- W4313487943 creator A5031714474 @default.
- W4313487943 creator A5037995106 @default.
- W4313487943 creator A5056939495 @default.
- W4313487943 creator A5072361932 @default.
- W4313487943 creator A5090170487 @default.
- W4313487943 date "2023-01-04" @default.
- W4313487943 modified "2023-10-17" @default.
- W4313487943 title "Beneficial effects of tannic acid on comorbid anxiety in cecal ligation and puncture-induced sepsis in rats and potential underlying mechanisms" @default.
- W4313487943 cites W2003129702 @default.
- W4313487943 cites W2031082712 @default.
- W4313487943 cites W2036607436 @default.
- W4313487943 cites W2057522312 @default.
- W4313487943 cites W2080238811 @default.
- W4313487943 cites W2092291222 @default.
- W4313487943 cites W2092953670 @default.
- W4313487943 cites W2099206674 @default.
- W4313487943 cites W2120932443 @default.
- W4313487943 cites W2136044952 @default.
- W4313487943 cites W2530157596 @default.
- W4313487943 cites W2558871855 @default.
- W4313487943 cites W2562104100 @default.
- W4313487943 cites W2600496322 @default.
- W4313487943 cites W2750243369 @default.
- W4313487943 cites W2770312732 @default.
- W4313487943 cites W2794554845 @default.
- W4313487943 cites W2902180436 @default.
- W4313487943 cites W2936666063 @default.
- W4313487943 cites W2942634769 @default.
- W4313487943 cites W2964273006 @default.
- W4313487943 cites W2974389792 @default.
- W4313487943 cites W3005652668 @default.
- W4313487943 cites W3005937827 @default.
- W4313487943 cites W3010377023 @default.
- W4313487943 cites W3023781031 @default.
- W4313487943 cites W3025286369 @default.
- W4313487943 cites W3033320057 @default.
- W4313487943 cites W3036360682 @default.
- W4313487943 cites W3048405504 @default.
- W4313487943 cites W3089772362 @default.
- W4313487943 cites W3092507656 @default.
- W4313487943 cites W3196174803 @default.
- W4313487943 cites W3204104160 @default.
- W4313487943 cites W3207979846 @default.
- W4313487943 doi "https://doi.org/10.1007/s00210-022-02374-5" @default.
- W4313487943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36598513" @default.
- W4313487943 hasPublicationYear "2023" @default.
- W4313487943 type Work @default.
- W4313487943 citedByCount "1" @default.
- W4313487943 countsByYear W43134879432023 @default.
- W4313487943 crossrefType "journal-article" @default.
- W4313487943 hasAuthorship W4313487943A5031714474 @default.
- W4313487943 hasAuthorship W4313487943A5037995106 @default.
- W4313487943 hasAuthorship W4313487943A5056939495 @default.
- W4313487943 hasAuthorship W4313487943A5072361932 @default.
- W4313487943 hasAuthorship W4313487943A5090170487 @default.
- W4313487943 hasBestOaLocation W43134879432 @default.
- W4313487943 hasConcept C126322002 @default.
- W4313487943 hasConcept C134018914 @default.
- W4313487943 hasConcept C178790620 @default.
- W4313487943 hasConcept C185592680 @default.
- W4313487943 hasConcept C2776151105 @default.
- W4313487943 hasConcept C2778384902 @default.
- W4313487943 hasConcept C2781161787 @default.
- W4313487943 hasConcept C2781393965 @default.
- W4313487943 hasConcept C42219234 @default.
- W4313487943 hasConcept C71924100 @default.
- W4313487943 hasConcept C98274493 @default.
- W4313487943 hasConceptScore W4313487943C126322002 @default.
- W4313487943 hasConceptScore W4313487943C134018914 @default.
- W4313487943 hasConceptScore W4313487943C178790620 @default.
- W4313487943 hasConceptScore W4313487943C185592680 @default.
- W4313487943 hasConceptScore W4313487943C2776151105 @default.
- W4313487943 hasConceptScore W4313487943C2778384902 @default.
- W4313487943 hasConceptScore W4313487943C2781161787 @default.
- W4313487943 hasConceptScore W4313487943C2781393965 @default.
- W4313487943 hasConceptScore W4313487943C42219234 @default.
- W4313487943 hasConceptScore W4313487943C71924100 @default.
- W4313487943 hasConceptScore W4313487943C98274493 @default.
- W4313487943 hasIssue "5" @default.
- W4313487943 hasLocation W43134879431 @default.
- W4313487943 hasLocation W43134879432 @default.
- W4313487943 hasLocation W43134879433 @default.
- W4313487943 hasOpenAccess W4313487943 @default.
- W4313487943 hasPrimaryLocation W43134879431 @default.
- W4313487943 hasRelatedWork W1966504330 @default.
- W4313487943 hasRelatedWork W1966775726 @default.
- W4313487943 hasRelatedWork W1979139803 @default.
- W4313487943 hasRelatedWork W1991560548 @default.
- W4313487943 hasRelatedWork W2030889776 @default.
- W4313487943 hasRelatedWork W2037631372 @default.
- W4313487943 hasRelatedWork W2040058909 @default.
- W4313487943 hasRelatedWork W2132898409 @default.
- W4313487943 hasRelatedWork W2748952813 @default.
- W4313487943 hasRelatedWork W4249176446 @default.
- W4313487943 hasVolume "396" @default.
- W4313487943 isParatext "false" @default.