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• W4313488112 abstract "Abstract Objective To improve our understanding of the immune response, including the neutralization antibody response, following COVID‐19 vaccination in pregnancy. Methods This was a prospective cohort study comprising patients with PCR‐confirmed SARS‐CoV‐2 infection and patients who received both doses of mRNA COVID‐19 vaccine (mRNA‐1273, BNT162b2) in pregnancy recruited from two hospitals in Atlanta, GA, USA. Maternal blood and cord blood at delivery were assayed for anti‐receptor binding domain (RBD) IgG, IgA and IgM, and neutralizing antibody. The detection of antibodies, titers, and maternal to fetal transfer ratios were compared. Results Nearly all patients had detectable RBD‐binding IgG in maternal and cord samples. The vaccinated versus infected cohort had a significantly greater proportion of cord samples with detectable neutralizing antibody (94% vs. 28%, P < 0.001) and significantly higher transfer ratios for RBD‐specific IgG and neutralizing antibodies with a transfer efficiency of 105% (vs. 80%, P < 0.001) and 110% (vs. 90%, P < 0.001), respectively. There was a significant linear decline in maternal and cord blood RBD‐specific IgG and neutralizing antibody titers as time from vaccination to delivery increased. Conclusions Those who receive the mRNA COVID‐19 vaccine mount an immune response that is equivalent to—if not greater than—those naturally infected by SARS‐CoV‐2 during pregnancy." @default.
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• W4313488112 date "2023-01-19" @default.
• W4313488112 modified "2023-10-16" @default.
• W4313488112 title "Antibody response, neutralizing potency, and transplacental antibody transfer following <scp>SARS‐CoV</scp>‐2 infection versus <scp>mRNA</scp>‐1273, <scp>BNT162b2 COVID</scp>‐19 vaccination in pregnancy" @default.
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• W4313488112 doi "https://doi.org/10.1002/ijgo.14648" @default.
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