FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313488158> ?p ?o ?g. }

• W4313488158 abstract "Macrophages are one of the main cellular targets of human immunodeficiency virus type 1 (HIV-1). Macrophage infection by HIV-1 is inefficient due to the presence of the viral restriction factor sterile alpha motif and histidine aspartic acid domain containing protein 1 (SAMHD1). Ex vivo human monocyte-derived macrophages (MDMs) express SAMHD1 in an equilibrium between active (unphosphorylated) and inactive (phosphorylated) states. We and others have shown that treatment of MDMs with the FDA-approved tyrosine kinase inhibitor, dasatinib, ablates SAMHD1 phosphorylation, thus skewing the balance towards a cellular state that is refractory to HIV-1 infection. We hypothesized that dasatinib inhibits a putative tyrosine kinase that is upstream of SAMHD1. In search for this tyrosine kinase, we probed several candidates and were unable to identify a single target that, when inhibited, was sufficient to explain the dephosphorylation of SAMHD1 we observe upon treatment with dasatinib. On the other hand, we probed the ability of dasatinib to directly inhibit the serine/threonine cyclin dependent kinases 1, 2, 4 and 6 and confirmed that dasatinib directly inhibits these kinases. Therefore, our results show that inhibition of the proximal CDKs 1, 2, 4 and 6 by dasatinib is clearly detectable, leads to blockade of infection by HIV-1, and may be sufficient to explain the activity of dasatinib against SAMHD1 phosphorylation." @default.
• W4313488158 created "2023-01-06" @default.
• W4313488158 creator A5001606196 @default.
• W4313488158 creator A5003732913 @default.
• W4313488158 creator A5036762753 @default.
• W4313488158 creator A5042773644 @default.
• W4313488158 creator A5045108590 @default.
• W4313488158 creator A5055452041 @default.
• W4313488158 creator A5061011421 @default.
• W4313488158 creator A5073208226 @default.
• W4313488158 creator A5087224920 @default.
• W4313488158 date "2022-01-01" @default.
• W4313488158 modified "2023-09-27" @default.
• W4313488158 title "Dasatinib: effects on the macrophage phospho proteome with a focus on SAMHD1 and HIV-1 infection." @default.
• W4313488158 cites W1548870648 @default.
• W4313488158 cites W1966903977 @default.
• W4313488158 cites W2000195190 @default.
• W4313488158 cites W2017279636 @default.
• W4313488158 cites W2019388385 @default.
• W4313488158 cites W2027853473 @default.
• W4313488158 cites W2056322765 @default.
• W4313488158 cites W2066106215 @default.
• W4313488158 cites W2069554621 @default.
• W4313488158 cites W2092606584 @default.
• W4313488158 cites W2097946794 @default.
• W4313488158 cites W2101381491 @default.
• W4313488158 cites W2101492432 @default.
• W4313488158 cites W2104574305 @default.
• W4313488158 cites W2117891939 @default.
• W4313488158 cites W2127664187 @default.
• W4313488158 cites W2141819122 @default.
• W4313488158 cites W2154715621 @default.
• W4313488158 cites W2156711667 @default.
• W4313488158 cites W2204308538 @default.
• W4313488158 cites W2240213927 @default.
• W4313488158 cites W2261805883 @default.
• W4313488158 cites W2273522648 @default.
• W4313488158 cites W2274212151 @default.
• W4313488158 cites W2294972389 @default.
• W4313488158 cites W2320158336 @default.
• W4313488158 cites W2341674440 @default.
• W4313488158 cites W2513468234 @default.
• W4313488158 cites W2582842684 @default.
• W4313488158 cites W2603755872 @default.
• W4313488158 cites W2766673110 @default.
• W4313488158 cites W2803336874 @default.
• W4313488158 cites W2803982612 @default.
• W4313488158 cites W2884169896 @default.
• W4313488158 cites W2896804758 @default.
• W4313488158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36589263" @default.
• W4313488158 hasPublicationYear "2022" @default.
• W4313488158 type Work @default.
• W4313488158 citedByCount "1" @default.
• W4313488158 countsByYear W43134881582023 @default.
• W4313488158 crossrefType "journal-article" @default.
• W4313488158 hasAuthorship W4313488158A5001606196 @default.
• W4313488158 hasAuthorship W4313488158A5003732913 @default.
• W4313488158 hasAuthorship W4313488158A5036762753 @default.
• W4313488158 hasAuthorship W4313488158A5042773644 @default.
• W4313488158 hasAuthorship W4313488158A5045108590 @default.
• W4313488158 hasAuthorship W4313488158A5055452041 @default.
• W4313488158 hasAuthorship W4313488158A5061011421 @default.
• W4313488158 hasAuthorship W4313488158A5073208226 @default.
• W4313488158 hasAuthorship W4313488158A5087224920 @default.
• W4313488158 hasConcept C104317684 @default.
• W4313488158 hasConcept C11960822 @default.
• W4313488158 hasConcept C121608353 @default.
• W4313488158 hasConcept C124320809 @default.
• W4313488158 hasConcept C1491633281 @default.
• W4313488158 hasConcept C156719811 @default.
• W4313488158 hasConcept C184235292 @default.
• W4313488158 hasConcept C2776315342 @default.
• W4313488158 hasConcept C2778820342 @default.
• W4313488158 hasConcept C2779536868 @default.
• W4313488158 hasConcept C29537977 @default.
• W4313488158 hasConcept C42362537 @default.
• W4313488158 hasConcept C54355233 @default.
• W4313488158 hasConcept C55493867 @default.
• W4313488158 hasConcept C62478195 @default.
• W4313488158 hasConcept C67705224 @default.
• W4313488158 hasConcept C86803240 @default.
• W4313488158 hasConcept C95444343 @default.
• W4313488158 hasConceptScore W4313488158C104317684 @default.
• W4313488158 hasConceptScore W4313488158C11960822 @default.
• W4313488158 hasConceptScore W4313488158C121608353 @default.
• W4313488158 hasConceptScore W4313488158C124320809 @default.
• W4313488158 hasConceptScore W4313488158C1491633281 @default.
• W4313488158 hasConceptScore W4313488158C156719811 @default.
• W4313488158 hasConceptScore W4313488158C184235292 @default.
• W4313488158 hasConceptScore W4313488158C2776315342 @default.
• W4313488158 hasConceptScore W4313488158C2778820342 @default.
• W4313488158 hasConceptScore W4313488158C2779536868 @default.
• W4313488158 hasConceptScore W4313488158C29537977 @default.
• W4313488158 hasConceptScore W4313488158C42362537 @default.
• W4313488158 hasConceptScore W4313488158C54355233 @default.
• W4313488158 hasConceptScore W4313488158C55493867 @default.
• W4313488158 hasConceptScore W4313488158C62478195 @default.
• W4313488158 hasConceptScore W4313488158C67705224 @default.
• W4313488158 hasConceptScore W4313488158C86803240 @default.
• W4313488158 hasConceptScore W4313488158C95444343 @default.

• next