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• W4313488382 abstract "A new worldwide concern has emerged with the recent emergence of infections caused by Candida auris. This reflects its comparative ease of transmission, substantial mortality, and the increasing level of resistance seen in the three major classes of antifungal drugs. Efforts to create a better design for structure-based drugs that described numerous modifications and the search for secondary metabolic structures derived from plant species are likely to reduce the virulence of several fungal pathogens. In this context, the present work aimed to evaluate in silico two naphthoquinones isolated from the roots of Capraria biflora, biflorin, and its dimmer, bis-biflorin, as potential inhibitors of Candida auris polymerase. Based on the simulation performed with the two naphthoquinones, biflorin and bis-biflorin, it can be stated that bis-biflorin showed the best interactions with Candida auris polymerase. Still, biflorin also demonstrated favorable coupling energy. Predictive pharmacokinetic assays suggest that biflorin has high oral bioavailability and more excellent metabolic stability compared to the bis-biflorin analogue. constituting a promising pharmacological tool.Communicated by Ramaswamy H. Sarma." @default.
• W4313488382 created "2023-01-06" @default.
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• W4313488382 date "2023-01-04" @default.
• W4313488382 modified "2023-10-01" @default.
• W4313488382 title "Naphthoquinones biflorin and bis-biflorin (<i>Capraria biflora</i>) as possible inhibitors of the fungus <i>Candida auris</i> polymerase: molecular docking, molecular dynamics, MM/GBSA calculations and <i>in silico</i> drug-likeness study" @default.
• W4313488382 cites W1567996984 @default.
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• W4313488382 cites W1987095367 @default.
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• W4313488382 cites W2001387448 @default.
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• W4313488382 doi "https://doi.org/10.1080/07391102.2022.2163702" @default.
• W4313488382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36597918" @default.
• W4313488382 hasPublicationYear "2023" @default.
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