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• W4313488505 endingPage "92" @default.
• W4313488505 startingPage "69" @default.
• W4313488505 abstract "Multiple sclerosis (MS) is a chronic autoimmune demyelinating and neurodegenerative disease of the central nervous system with a wide variety of clinical phenotypes. In spite of the phenotypic classification of MS patients, current data provide evidence that diffuse neuroinflammation and neurodegeneration coexist in all MS forms, the latter gaining increasing clinical relevance in progressive phases. Given that the transition phase of relapsing-remitting MS (RRMS) to secondary progressive MS (SPMS) is not well defined, and widely accepted criteria for SPMS are lacking, randomised controlled trials (RCTs) specifically designed for the transition phase have not been conducted. This review summarizes primary and secondary analyses and reports derived from phase III prospective clinical RCTs listed in PubMed of compounds authorised through the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) for the treatment of MS. The best data are available for interferon beta-1a (IFNb-1a) subcutaneous (s.c.), IFNb-1b s.c., mitoxantrone and siponimod, the latter being the most modern compound with likely the best risk-to-effect ratio. Moreover, there is a labels discrepancy for many disease-modifying treatments (DMTs) between the FDA and EMA, which have to be taken into consideration when opting for a specific DMT." @default.
• W4313488505 created "2023-01-06" @default.
• W4313488505 creator A5012275404 @default.
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• W4313488505 creator A5034872348 @default.
• W4313488505 creator A5065061887 @default.
• W4313488505 creator A5082233226 @default.
• W4313488505 date "2023-01-01" @default.
• W4313488505 modified "2023-10-06" @default.
• W4313488505 title "Treatment of Patients with Multiple Sclerosis Transitioning Between Relapsing and Progressive Disease" @default.
• W4313488505 cites W1537248629 @default.
• W4313488505 cites W1967507425 @default.
• W4313488505 cites W1967838438 @default.
• W4313488505 cites W1969129043 @default.
• W4313488505 cites W1970663794 @default.
• W4313488505 cites W1976243978 @default.
• W4313488505 cites W1982495693 @default.
• W4313488505 cites W1986991730 @default.
• W4313488505 cites W1987053154 @default.
• W4313488505 cites W1997880566 @default.
• W4313488505 cites W2000349584 @default.
• W4313488505 cites W2025694051 @default.
• W4313488505 cites W2026092194 @default.
• W4313488505 cites W2039497421 @default.
• W4313488505 cites W2043591841 @default.
• W4313488505 cites W2045273967 @default.
• W4313488505 cites W2057431866 @default.
• W4313488505 cites W2086091627 @default.
• W4313488505 cites W2088453744 @default.
• W4313488505 cites W2093009907 @default.
• W4313488505 cites W2097669496 @default.
• W4313488505 cites W2103758700 @default.
• W4313488505 cites W2104301864 @default.
• W4313488505 cites W2104948944 @default.
• W4313488505 cites W2105206040 @default.
• W4313488505 cites W2112165124 @default.
• W4313488505 cites W2118735809 @default.
• W4313488505 cites W2119172537 @default.
• W4313488505 cites W2122542523 @default.
• W4313488505 cites W2122999365 @default.
• W4313488505 cites W2127001605 @default.
• W4313488505 cites W2129967156 @default.
• W4313488505 cites W2131960843 @default.
• W4313488505 cites W2133329597 @default.
• W4313488505 cites W2135440918 @default.
• W4313488505 cites W2139204856 @default.
• W4313488505 cites W2139367012 @default.
• W4313488505 cites W2139560482 @default.
• W4313488505 cites W2141919552 @default.
• W4313488505 cites W2142577589 @default.
• W4313488505 cites W2146662840 @default.
• W4313488505 cites W2148677082 @default.
• W4313488505 cites W2148766438 @default.
• W4313488505 cites W2151340435 @default.
• W4313488505 cites W2158202057 @default.
• W4313488505 cites W2162978315 @default.
• W4313488505 cites W2163394083 @default.
• W4313488505 cites W2169098250 @default.
• W4313488505 cites W2233606434 @default.
• W4313488505 cites W2267348707 @default.
• W4313488505 cites W2296989255 @default.
• W4313488505 cites W2397308456 @default.
• W4313488505 cites W2464491214 @default.
• W4313488505 cites W2471246678 @default.
• W4313488505 cites W2561881161 @default.
• W4313488505 cites W2565433170 @default.
• W4313488505 cites W2574627421 @default.
• W4313488505 cites W2618423461 @default.
• W4313488505 cites W2620062671 @default.
• W4313488505 cites W2752554587 @default.
• W4313488505 cites W2767362256 @default.
• W4313488505 cites W2790816436 @default.
• W4313488505 cites W2793526309 @default.
• W4313488505 cites W2909270098 @default.
• W4313488505 cites W2920592419 @default.
• W4313488505 cites W2922528121 @default.
• W4313488505 cites W2955819068 @default.
• W4313488505 cites W2971487735 @default.
• W4313488505 cites W2971577153 @default.
• W4313488505 cites W2977010198 @default.
• W4313488505 cites W2998920613 @default.
• W4313488505 cites W3012254007 @default.
• W4313488505 cites W3026936125 @default.
• W4313488505 cites W3029315732 @default.
• W4313488505 cites W3033968144 @default.
• W4313488505 cites W3047302551 @default.
• W4313488505 cites W3084064893 @default.
• W4313488505 cites W3096310943 @default.
• W4313488505 cites W3116218681 @default.
• W4313488505 cites W3122113057 @default.
• W4313488505 cites W3149798718 @default.
• W4313488505 cites W3157239883 @default.
• W4313488505 cites W3160486350 @default.
• W4313488505 cites W3176563303 @default.
• W4313488505 cites W3176688419 @default.
• W4313488505 cites W3184969801 @default.
• W4313488505 cites W3207622496 @default.
• W4313488505 cites W3207899699 @default.

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