FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313488595> ?p ?o ?g. }

• W4313488595 abstract "Tigecycline has in vitro bacteriostatic activity against a broad spectrum of bacteria, including carbapenem-resistant Gram-negative bacteria (CR-GNB). However, the role of tigecycline in treatment of nosocomial pneumonia caused by CR-GNB remains controversial and clinical evidences are limited. We aimed to investigate the clinical benefits of tigecycline as part of the combination treatment of nosocomial CR-GNB pneumonia in intensive care unit (ICU).This multi-centre cohort study retrospectively enrolled ICU-admitted patients with nosocomial pneumonia caused by CR-GNB. Patients were categorized based on whether add-on tigecycline was used in combination with at least one anti-CR-GNB antibiotic. Clinical outcomes and all-cause mortality between patients with and without tigecycline were compared in the original and propensity score (PS)-matched cohorts. A subgroup analysis was also performed to explore the differences of clinical efficacies of add-on tigecycline treatment when combined with various anti-CR-GNB agents.We analysed 395 patients with CR-GNB nosocomial pneumonia, of whom 148 received tigecycline and 247 did not. More than 80% of the enrolled patients were infected by CR-Acinetobacter baumannii (CRAB). A trend of lower all-cause mortality on day 28 was noted in tigecycline group in the original cohort (27.7% vs. 36.0%, p = 0.088). In PS-matched cohort (102 patient pairs), patients with tigecycline had significantly lower clinical failure (46.1% vs. 62.7%, p = 0.017) and mortality rates (28.4% vs. 52.9%, p < 0.001) on day 28. In multivariate analysis, tigecycline treatment was a protective factor against clinical failure (PS-matched cohort: aOR 0.52, 95% CI 0.28-0.95) and all-cause mortality (original cohort: aHR 0.69, 95% CI 0.47-0.99; PS-matched cohort: aHR 0.47, 95% CI 0.30-0.74) at 28 days. Kaplan-Meier survival analysis in subgroups of patients suggested significant clinical benefits of tigecycline when added to a colistin-included (log rank p value 0.005) and carbapenem-included (log rank p value 0.007) combination regimen.In this retrospective observational study that included ICU-admitted patients with nosocomial pneumonia caused by tigecycline-susceptible CR-GNB, mostly CRAB, tigecycline as part of a combination treatment regimen was associated with lower clinical failure and all-cause mortality rates." @default.
• W4313488595 created "2023-01-06" @default.
• W4313488595 creator A5017489241 @default.
• W4313488595 creator A5024233272 @default.
• W4313488595 creator A5024724363 @default.
• W4313488595 creator A5030973241 @default.
• W4313488595 creator A5035619863 @default.
• W4313488595 creator A5040142887 @default.
• W4313488595 creator A5040738592 @default.
• W4313488595 creator A5045825529 @default.
• W4313488595 creator A5052380151 @default.
• W4313488595 creator A5061526243 @default.
• W4313488595 date "2023-01-03" @default.
• W4313488595 modified "2023-10-14" @default.
• W4313488595 title "Clinical effectiveness of tigecycline in combination therapy against nosocomial pneumonia caused by CR-GNB in intensive care units: a retrospective multi-centre observational study" @default.
• W4313488595 cites W1465225786 @default.
• W4313488595 cites W1985109169 @default.
• W4313488595 cites W2006989561 @default.
• W4313488595 cites W2055297383 @default.
• W4313488595 cites W2064648176 @default.
• W4313488595 cites W2078561636 @default.
• W4313488595 cites W2096338321 @default.
• W4313488595 cites W2111635289 @default.
• W4313488595 cites W2136450019 @default.
• W4313488595 cites W2137408524 @default.
• W4313488595 cites W2153850990 @default.
• W4313488595 cites W2169847442 @default.
• W4313488595 cites W2202739373 @default.
• W4313488595 cites W2227953089 @default.
• W4313488595 cites W2464655073 @default.
• W4313488595 cites W2473016454 @default.
• W4313488595 cites W2509557099 @default.
• W4313488595 cites W2766228807 @default.
• W4313488595 cites W2895497511 @default.
• W4313488595 cites W2909686608 @default.
• W4313488595 cites W2911959439 @default.
• W4313488595 cites W2966408359 @default.
• W4313488595 cites W3019205265 @default.
• W4313488595 cites W3042822489 @default.
• W4313488595 cites W3094338265 @default.
• W4313488595 cites W3126332138 @default.
• W4313488595 cites W3158468349 @default.
• W4313488595 cites W3185640361 @default.
• W4313488595 cites W3186398894 @default.
• W4313488595 cites W3197702115 @default.
• W4313488595 cites W3206422054 @default.
• W4313488595 cites W4200036649 @default.
• W4313488595 cites W4200250437 @default.
• W4313488595 cites W4220656053 @default.
• W4313488595 cites W4229924182 @default.
• W4313488595 doi "https://doi.org/10.1186/s40560-022-00647-y" @default.
• W4313488595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36597165" @default.
• W4313488595 hasPublicationYear "2023" @default.
• W4313488595 type Work @default.
• W4313488595 citedByCount "0" @default.
• W4313488595 crossrefType "journal-article" @default.
• W4313488595 hasAuthorship W4313488595A5017489241 @default.
• W4313488595 hasAuthorship W4313488595A5024233272 @default.
• W4313488595 hasAuthorship W4313488595A5024724363 @default.
• W4313488595 hasAuthorship W4313488595A5030973241 @default.
• W4313488595 hasAuthorship W4313488595A5035619863 @default.
• W4313488595 hasAuthorship W4313488595A5040142887 @default.
• W4313488595 hasAuthorship W4313488595A5040738592 @default.
• W4313488595 hasAuthorship W4313488595A5045825529 @default.
• W4313488595 hasAuthorship W4313488595A5052380151 @default.
• W4313488595 hasAuthorship W4313488595A5061526243 @default.
• W4313488595 hasBestOaLocation W43134885951 @default.
• W4313488595 hasConcept C126322002 @default.
• W4313488595 hasConcept C167135981 @default.
• W4313488595 hasConcept C17923572 @default.
• W4313488595 hasConcept C201903717 @default.
• W4313488595 hasConcept C2776315533 @default.
• W4313488595 hasConcept C2776376669 @default.
• W4313488595 hasConcept C2777027569 @default.
• W4313488595 hasConcept C2777637488 @default.
• W4313488595 hasConcept C2777914695 @default.
• W4313488595 hasConcept C501593827 @default.
• W4313488595 hasConcept C523546767 @default.
• W4313488595 hasConcept C54355233 @default.
• W4313488595 hasConcept C71924100 @default.
• W4313488595 hasConcept C72563966 @default.
• W4313488595 hasConcept C86803240 @default.
• W4313488595 hasConcept C89423630 @default.
• W4313488595 hasConceptScore W4313488595C126322002 @default.
• W4313488595 hasConceptScore W4313488595C167135981 @default.
• W4313488595 hasConceptScore W4313488595C17923572 @default.
• W4313488595 hasConceptScore W4313488595C201903717 @default.
• W4313488595 hasConceptScore W4313488595C2776315533 @default.
• W4313488595 hasConceptScore W4313488595C2776376669 @default.
• W4313488595 hasConceptScore W4313488595C2777027569 @default.
• W4313488595 hasConceptScore W4313488595C2777637488 @default.
• W4313488595 hasConceptScore W4313488595C2777914695 @default.
• W4313488595 hasConceptScore W4313488595C501593827 @default.
• W4313488595 hasConceptScore W4313488595C523546767 @default.
• W4313488595 hasConceptScore W4313488595C54355233 @default.
• W4313488595 hasConceptScore W4313488595C71924100 @default.
• W4313488595 hasConceptScore W4313488595C72563966 @default.
• W4313488595 hasConceptScore W4313488595C86803240 @default.
• W4313488595 hasConceptScore W4313488595C89423630 @default.
• W4313488595 hasFunder F4320323275 @default.

• next