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- W4313488703 abstract "Glycopeptide antibiotics (GPAs) are a family of non-ribosomal peptide natural products with polypeptide skeleton characteristics, which are considered the last resort for treating severe infections caused by multidrug-resistant Gram-positive pathogens. Over the past few years, an increasing prevalence of Gram-positive resistant strain superbugs has emerged. Therefore, more efforts are needed to study and modify the GPAs to overcome the challenge of superbugs. In this mini-review, we provide an overview of the complex biosynthetic gene clusters (BGCs), the ingenious crosslinking and tailoring modifications, the new GPA derivatives, the discoveries of new natural GPAs, and the new applications of GPAs in antivirus and anti-Gram-negative bacteria. With the development and interdisciplinary integration of synthetic biology, next-generation sequencing (NGS), and artificial intelligence (AI), more GPAs with new chemical structures and action mechanisms will constantly be emerging." @default.
- W4313488703 created "2023-01-06" @default.
- W4313488703 creator A5009325568 @default.
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- W4313488703 creator A5040718239 @default.
- W4313488703 creator A5043204530 @default.
- W4313488703 creator A5062371912 @default.
- W4313488703 date "2023-01-03" @default.
- W4313488703 modified "2023-10-14" @default.
- W4313488703 title "Newest perspectives of glycopeptide antibiotics: biosynthetic cascades, novel derivatives, and new appealing antimicrobial applications" @default.
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- W4313488703 doi "https://doi.org/10.1007/s11274-022-03512-0" @default.
- W4313488703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36593427" @default.
- W4313488703 hasPublicationYear "2023" @default.
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