Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313488712> ?p ?o ?g. }
- W4313488712 endingPage "501" @default.
- W4313488712 startingPage "489" @default.
- W4313488712 abstract "Proton beam radiotherapy (PRT) has been demonstrated to improve neurocognitive sequelae particularly. Nevertheless, following PRT, increased rates of radiation-induced contrast enhancements (RICE) are feared. How safe and effective is PRT for IDH-mutated glioma WHO grade 2 and 3?We analyzed 194 patients diagnosed with IDH-mutated WHO grade 2 (n = 128) and WHO grade 3 (n = 66) glioma who were treated with PRT from 2010 to 2020. Serial clinical and imaging follow-up was performed for a median of 5.1 years.For WHO grade 2, 61% were astrocytoma and 39% oligodendroglioma while for WHO grade 3, 55% were astrocytoma and 45% oligodendroglioma. Median dose for IDH-mutated glioma was 54 Gy(RBE) [range 50.4-60 Gy(RBE)] for WHO grade 2 and 60 Gy(RBE) [range 54-60 Gy(RBE)] for WHO grade 3. Five year overall survival was 85% in patients with WHO grade 2 and 67% in patients with WHO grade 3 tumors. Overall RICE risk was 25%, being higher in patients with WHO grade 2 (29%) versus in patients with WHO grade 3 (17%, p = 0.13). RICE risk increased independent of tumor characteristics with older age (p = 0.017). Overall RICE was symptomatic in 31% of patients with corresponding CTCAE grades as follows: 80% grade 1, 7% grade 2, 13% grade 3, and 0% grade 3 + . Overall need for RICE-directed therapy was 35%.These data demonstrate the effectiveness of PRT for IDH-mutated glioma WHO grade 2 and 3. The RICE risk differs with WHO grading and is higher in older patients with IDH-mutated Glioma WHO grade 2 and 3." @default.
- W4313488712 created "2023-01-06" @default.
- W4313488712 creator A5000073064 @default.
- W4313488712 creator A5010170241 @default.
- W4313488712 creator A5010687963 @default.
- W4313488712 creator A5016801239 @default.
- W4313488712 creator A5025180611 @default.
- W4313488712 creator A5027505941 @default.
- W4313488712 creator A5042791450 @default.
- W4313488712 creator A5045520915 @default.
- W4313488712 creator A5057500818 @default.
- W4313488712 creator A5070438052 @default.
- W4313488712 creator A5070621357 @default.
- W4313488712 creator A5071865752 @default.
- W4313488712 creator A5080916428 @default.
- W4313488712 creator A5081543556 @default.
- W4313488712 creator A5084960047 @default.
- W4313488712 date "2023-01-04" @default.
- W4313488712 modified "2023-10-13" @default.
- W4313488712 title "Analysis of safety and efficacy of proton radiotherapy for IDH-mutated glioma WHO grade 2 and 3" @default.
- W4313488712 cites W1695525132 @default.
- W4313488712 cites W2022807308 @default.
- W4313488712 cites W2023179262 @default.
- W4313488712 cites W2052527703 @default.
- W4313488712 cites W2059260164 @default.
- W4313488712 cites W2059829307 @default.
- W4313488712 cites W2097512974 @default.
- W4313488712 cites W2113422054 @default.
- W4313488712 cites W2116232743 @default.
- W4313488712 cites W2119838967 @default.
- W4313488712 cites W2126817554 @default.
- W4313488712 cites W2133865472 @default.
- W4313488712 cites W2147013683 @default.
- W4313488712 cites W2149918777 @default.
- W4313488712 cites W2205491567 @default.
- W4313488712 cites W2313086999 @default.
- W4313488712 cites W2338350735 @default.
- W4313488712 cites W2460821456 @default.
- W4313488712 cites W2505666614 @default.
- W4313488712 cites W2744160381 @default.
- W4313488712 cites W2783983963 @default.
- W4313488712 cites W2787816121 @default.
- W4313488712 cites W2887682196 @default.
- W4313488712 cites W2901166159 @default.
- W4313488712 cites W2903061646 @default.
- W4313488712 cites W2913316533 @default.
- W4313488712 cites W2914229690 @default.
- W4313488712 cites W2916850088 @default.
- W4313488712 cites W2967838257 @default.
- W4313488712 cites W2991588978 @default.
- W4313488712 cites W3013098905 @default.
- W4313488712 cites W3044938198 @default.
- W4313488712 cites W3047582945 @default.
- W4313488712 cites W3082797372 @default.
- W4313488712 cites W3110787789 @default.
- W4313488712 cites W3113537649 @default.
- W4313488712 cites W3124619990 @default.
- W4313488712 cites W3161800158 @default.
- W4313488712 cites W3174246647 @default.
- W4313488712 cites W3180953242 @default.
- W4313488712 cites W4200355852 @default.
- W4313488712 cites W4280528478 @default.
- W4313488712 cites W4281855457 @default.
- W4313488712 cites W4293330667 @default.
- W4313488712 cites W4293503695 @default.
- W4313488712 cites W4293503761 @default.
- W4313488712 cites W571060166 @default.
- W4313488712 doi "https://doi.org/10.1007/s11060-022-04217-y" @default.
- W4313488712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36598613" @default.
- W4313488712 hasPublicationYear "2023" @default.
- W4313488712 type Work @default.
- W4313488712 citedByCount "1" @default.
- W4313488712 countsByYear W43134887122023 @default.
- W4313488712 crossrefType "journal-article" @default.
- W4313488712 hasAuthorship W4313488712A5000073064 @default.
- W4313488712 hasAuthorship W4313488712A5010170241 @default.
- W4313488712 hasAuthorship W4313488712A5010687963 @default.
- W4313488712 hasAuthorship W4313488712A5016801239 @default.
- W4313488712 hasAuthorship W4313488712A5025180611 @default.
- W4313488712 hasAuthorship W4313488712A5027505941 @default.
- W4313488712 hasAuthorship W4313488712A5042791450 @default.
- W4313488712 hasAuthorship W4313488712A5045520915 @default.
- W4313488712 hasAuthorship W4313488712A5057500818 @default.
- W4313488712 hasAuthorship W4313488712A5070438052 @default.
- W4313488712 hasAuthorship W4313488712A5070621357 @default.
- W4313488712 hasAuthorship W4313488712A5071865752 @default.
- W4313488712 hasAuthorship W4313488712A5080916428 @default.
- W4313488712 hasAuthorship W4313488712A5081543556 @default.
- W4313488712 hasAuthorship W4313488712A5084960047 @default.
- W4313488712 hasBestOaLocation W43134887121 @default.
- W4313488712 hasConcept C126322002 @default.
- W4313488712 hasConcept C143998085 @default.
- W4313488712 hasConcept C18903297 @default.
- W4313488712 hasConcept C2777286243 @default.
- W4313488712 hasConcept C2777931997 @default.
- W4313488712 hasConcept C2778227246 @default.
- W4313488712 hasConcept C2778880634 @default.
- W4313488712 hasConcept C2989005 @default.