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• W4313488753 abstract "Abstract Previous studies have demonstrated that lipopolysaccharide (LPS), as a central toxic factor of gram‐negative bacteria, can induce oxidative stress and cellular inflammation to result in the impairment of female fertility in different organisms. Particularly, it has harmful effects on the oocyte quality and subsequent embryonic development. However, the approach concerning how to prevent oocytes from LPS‐induced deterioration still remains largely unexplored. We assessed the effective influences of velvet antler water extract (VAWE) by immunostaining and fluorescence intensity quantification on the meiotic maturation, mitochondrial function and sperm binding ability of oocytes under oxidative stress. Here, we report that VAWE treatment restores the quality of porcine oocytes exposed to LPS. Specifically, LPS exposure contributed to the failed oocyte maturation, reduced sperm binding ability and fertilization capability by disturbing the dynamics and arrangement of meiotic apparatuses and organelles, including spindle assembly, chromosome alignment, actin polymerization, mitochondrial dynamics and cortical granule distribution, the indicators of oocyte nuclear and cytoplasmic maturation. Notably, VAWE treatment recovered these meiotic defects by removing the LPS‐induced excessive ROS and thus inhibiting the apoptosis. Collectively, our study illustrates that VAWE treatment is a feasible strategy to improve the oocyte quality deteriorated by the LPS‐induced oxidative stress." @default.
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• W4313488753 date "2023-01-03" @default.
• W4313488753 modified "2023-09-26" @default.
• W4313488753 title "Velvet antler water extract protects porcine oocytes from lipopolysaccharide‐induced meiotic defects" @default.
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• W4313488753 doi "https://doi.org/10.1111/cpr.13392" @default.
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