Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313488756> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4313488756 abstract "Abstract Background To evaluate the effect of addition of ruxolitinib in Graft‐versus‐Host Disease (GVHD) prophylaxis on pediatric patients with β‐thalassemia major after allogeneic hematopoietic stem cell transplantation(HSCT). Methods This retrospective study reviewed 49 consecutive β‐thalassemia major pediatric patients who underwent HSCT from unrelated or haploidentical donors from February 2018 to October 2022. All transplantation recipients received cyclosporine A (CsA), mycophenolate mofetil (MMF), and short‐term methotrexate (MTX) as GVHD prophylaxis; while 27 of them in the ruxolitinib group had added ruxolitinib oral to GVHD prophylaxis regimen at 2.5 mg twice daily once successful engraftment after January 2020. Results The outcome showed that the ruxolitinib group had a lower cumulative incidence than the control group regardless of acute GVHD (22.2% vs.40.9%; p = .153) or chronic GVHD (18.5% vs.40.9%; p = .072); especially, the incidence of grade III‐IV acute GVHD was reported significantly less frequently in ruxolitinib group than that of the control group (0 vs. 27.3%, p = .005). No significant difference was detected between the two groups in EBV (Epstein–Barr virus)/CMV (cytomegalovirus) reactivation and BKV (BK virus) infection ( p = .703, 1.000, and .436, respectively). Twenty‐six patients (96.3%) in the ruxolitinib group were alive, while two patients (9.1%) in the control group died of intestinal acute GVHD. The 2‐year overall survival (OS) and thalassemia‐free survival (TFS) were both 96.296% in the ruxolitinib group, while both 90.909% in the control group. Conclusion This study reveals that ruxolitinib prophylaxis is a promising option to decrease the incidence of grade III‐IV acute GVHD in pediatric patients with β‐thalassemia major." @default.
- W4313488756 created "2023-01-06" @default.
- W4313488756 creator A5002537755 @default.
- W4313488756 creator A5010517165 @default.
- W4313488756 creator A5015832664 @default.
- W4313488756 creator A5030374840 @default.
- W4313488756 date "2023-01-03" @default.
- W4313488756 modified "2023-10-01" @default.
- W4313488756 title "Addition of ruxolitinib in <scp>Graft‐versus‐Host</scp> disease prophylaxis for pediatric <scp>β‐Thalassemia</scp> major patients after allogeneic stem cell transplantation: A retrospective cohort study" @default.
- W4313488756 cites W1986677646 @default.
- W4313488756 cites W1993860179 @default.
- W4313488756 cites W2004645291 @default.
- W4313488756 cites W2032313248 @default.
- W4313488756 cites W2106721661 @default.
- W4313488756 cites W2130948352 @default.
- W4313488756 cites W2167739766 @default.
- W4313488756 cites W2238351347 @default.
- W4313488756 cites W2379365975 @default.
- W4313488756 cites W2401011429 @default.
- W4313488756 cites W2598185545 @default.
- W4313488756 cites W2784147480 @default.
- W4313488756 cites W2794083546 @default.
- W4313488756 cites W2890092744 @default.
- W4313488756 cites W2926774858 @default.
- W4313488756 cites W2969508088 @default.
- W4313488756 cites W3001276384 @default.
- W4313488756 cites W3002819959 @default.
- W4313488756 cites W3017383148 @default.
- W4313488756 cites W3020112827 @default.
- W4313488756 cites W3145694737 @default.
- W4313488756 cites W3154826771 @default.
- W4313488756 cites W4247737273 @default.
- W4313488756 doi "https://doi.org/10.1111/petr.14466" @default.
- W4313488756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36597217" @default.
- W4313488756 hasPublicationYear "2023" @default.
- W4313488756 type Work @default.
- W4313488756 citedByCount "2" @default.
- W4313488756 countsByYear W43134887562023 @default.
- W4313488756 crossrefType "journal-article" @default.
- W4313488756 hasAuthorship W4313488756A5002537755 @default.
- W4313488756 hasAuthorship W4313488756A5010517165 @default.
- W4313488756 hasAuthorship W4313488756A5015832664 @default.
- W4313488756 hasAuthorship W4313488756A5030374840 @default.
- W4313488756 hasBestOaLocation W43134887561 @default.
- W4313488756 hasConcept C120665830 @default.
- W4313488756 hasConcept C121332964 @default.
- W4313488756 hasConcept C126322002 @default.
- W4313488756 hasConcept C141071460 @default.
- W4313488756 hasConcept C167135981 @default.
- W4313488756 hasConcept C2776112149 @default.
- W4313488756 hasConcept C2777408962 @default.
- W4313488756 hasConcept C2777799968 @default.
- W4313488756 hasConcept C2779972918 @default.
- W4313488756 hasConcept C2780007613 @default.
- W4313488756 hasConcept C2780076729 @default.
- W4313488756 hasConcept C2911091166 @default.
- W4313488756 hasConcept C61511704 @default.
- W4313488756 hasConcept C71924100 @default.
- W4313488756 hasConcept C72563966 @default.
- W4313488756 hasConcept C88879693 @default.
- W4313488756 hasConcept C90924648 @default.
- W4313488756 hasConceptScore W4313488756C120665830 @default.
- W4313488756 hasConceptScore W4313488756C121332964 @default.
- W4313488756 hasConceptScore W4313488756C126322002 @default.
- W4313488756 hasConceptScore W4313488756C141071460 @default.
- W4313488756 hasConceptScore W4313488756C167135981 @default.
- W4313488756 hasConceptScore W4313488756C2776112149 @default.
- W4313488756 hasConceptScore W4313488756C2777408962 @default.
- W4313488756 hasConceptScore W4313488756C2777799968 @default.
- W4313488756 hasConceptScore W4313488756C2779972918 @default.
- W4313488756 hasConceptScore W4313488756C2780007613 @default.
- W4313488756 hasConceptScore W4313488756C2780076729 @default.
- W4313488756 hasConceptScore W4313488756C2911091166 @default.
- W4313488756 hasConceptScore W4313488756C61511704 @default.
- W4313488756 hasConceptScore W4313488756C71924100 @default.
- W4313488756 hasConceptScore W4313488756C72563966 @default.
- W4313488756 hasConceptScore W4313488756C88879693 @default.
- W4313488756 hasConceptScore W4313488756C90924648 @default.
- W4313488756 hasIssue "2" @default.
- W4313488756 hasLocation W43134887561 @default.
- W4313488756 hasLocation W43134887562 @default.
- W4313488756 hasOpenAccess W4313488756 @default.
- W4313488756 hasPrimaryLocation W43134887561 @default.
- W4313488756 hasRelatedWork W2004368639 @default.
- W4313488756 hasRelatedWork W2360260519 @default.
- W4313488756 hasRelatedWork W2415666441 @default.
- W4313488756 hasRelatedWork W3031996156 @default.
- W4313488756 hasRelatedWork W3039265579 @default.
- W4313488756 hasRelatedWork W3116752139 @default.
- W4313488756 hasRelatedWork W3125696196 @default.
- W4313488756 hasRelatedWork W3133718536 @default.
- W4313488756 hasRelatedWork W3135392213 @default.
- W4313488756 hasRelatedWork W4231152149 @default.
- W4313488756 hasVolume "27" @default.
- W4313488756 isParatext "false" @default.
- W4313488756 isRetracted "false" @default.
- W4313488756 workType "article" @default.