FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313488798> ?p ?o ?g. }

• W4313488798 abstract "Bacterial defense barriers, such as DNA methylation-associated restriction-modification (R-M) and the CRISPR-Cas system, play an important role in bacterial antimicrobial resistance (AMR). Recently, a novel R-M system based on DNA phosphorothioate (PT) modification has been shown to be widespread in the kingdom of Bacteria as well as Archaea. However, the potential role of the PT R-M system in bacterial AMR remains unclear. In this study, we explored the role of PT R-Ms in AMR with a series of common clinical pathogenic bacteria. By analyzing the distribution of AMR genes related to mobile genetic elements (MGEs), it was shown that the presence of PT R-M effectively reduced the distribution of horizontal gene transfer (HGT)-derived AMR genes in the genome, even in the bacteria that did not tend to acquire AMR genes by HGT. In addition, unique gene variation analysis based on pangenome analysis and MGE prediction revealed that the presence of PT R-M could suppress HGT frequency. Thus, this is the first report showing that the PT R-M system has the potential to repress HGT-derived AMR gene acquisition by reducing the HGT frequency. IMPORTANCE In this study, we demonstrated the effect of DNA PT modification-based R-M systems on horizontal gene transfer of AMR genes in pathogenic bacteria. We show that there is no apparent association between the genetic background of the strains harboring PT R-Ms and the number of AMR genes or the kinds of gene families. The strains equipped with PT R-M harbor fewer plasmid-derived, prophage-derived, or integrating mobile genetic element (iMGE)-related AMR genes and have a lower HGT frequency, but the degree of inhibition varies among different bacteria. In addition, compared with Salmonella enterica and Escherichia coli, Klebsiella pneumoniae prefers to acquire MGE-derived AMR genes, and there is no coevolution between PT R-M clusters and bacterial core genes." @default.
• W4313488798 created "2023-01-06" @default.
• W4313488798 creator A5005995308 @default.
• W4313488798 creator A5006857370 @default.
• W4313488798 creator A5007588252 @default.
• W4313488798 creator A5027116236 @default.
• W4313488798 creator A5044549423 @default.
• W4313488798 creator A5053475062 @default.
• W4313488798 creator A5059228473 @default.
• W4313488798 creator A5070860231 @default.
• W4313488798 creator A5073069952 @default.
• W4313488798 creator A5074461919 @default.
• W4313488798 date "2023-02-14" @default.
• W4313488798 modified "2023-09-26" @default.
• W4313488798 title "The DNA Phosphorothioation Restriction-Modification System Influences the Antimicrobial Resistance of Pathogenic Bacteria" @default.
• W4313488798 cites W1760095190 @default.
• W4313488798 cites W1983888098 @default.
• W4313488798 cites W1983926688 @default.
• W4313488798 cites W1998157707 @default.
• W4313488798 cites W2005350671 @default.
• W4313488798 cites W2010122109 @default.
• W4313488798 cites W2016315684 @default.
• W4313488798 cites W2018273458 @default.
• W4313488798 cites W2030323881 @default.
• W4313488798 cites W2034302623 @default.
• W4313488798 cites W2038662968 @default.
• W4313488798 cites W2047058604 @default.
• W4313488798 cites W2048895938 @default.
• W4313488798 cites W2057168828 @default.
• W4313488798 cites W2060425093 @default.
• W4313488798 cites W2070099253 @default.
• W4313488798 cites W2074663598 @default.
• W4313488798 cites W2078151980 @default.
• W4313488798 cites W2096093282 @default.
• W4313488798 cites W2097162882 @default.
• W4313488798 cites W2098417493 @default.
• W4313488798 cites W2104485225 @default.
• W4313488798 cites W2105329815 @default.
• W4313488798 cites W2107903949 @default.
• W4313488798 cites W2115888213 @default.
• W4313488798 cites W2116475900 @default.
• W4313488798 cites W2122673596 @default.
• W4313488798 cites W2124363431 @default.
• W4313488798 cites W2126944400 @default.
• W4313488798 cites W2127774996 @default.
• W4313488798 cites W2130124027 @default.
• W4313488798 cites W2136723682 @default.
• W4313488798 cites W2137561105 @default.
• W4313488798 cites W2139321752 @default.
• W4313488798 cites W2141149764 @default.
• W4313488798 cites W2142654521 @default.
• W4313488798 cites W2143325926 @default.
• W4313488798 cites W2163330376 @default.
• W4313488798 cites W2174705797 @default.
• W4313488798 cites W2174972341 @default.
• W4313488798 cites W2277953252 @default.
• W4313488798 cites W2318209259 @default.
• W4313488798 cites W2399329356 @default.
• W4313488798 cites W2412140074 @default.
• W4313488798 cites W2460324897 @default.
• W4313488798 cites W2460333423 @default.
• W4313488798 cites W2475182620 @default.
• W4313488798 cites W2544493586 @default.
• W4313488798 cites W2590256596 @default.
• W4313488798 cites W2615583214 @default.
• W4313488798 cites W2621446108 @default.
• W4313488798 cites W2742846446 @default.
• W4313488798 cites W2789357097 @default.
• W4313488798 cites W2792564185 @default.
• W4313488798 cites W2803074811 @default.
• W4313488798 cites W2803245377 @default.
• W4313488798 cites W2809571030 @default.
• W4313488798 cites W2833799666 @default.
• W4313488798 cites W2885680427 @default.
• W4313488798 cites W2889178232 @default.
• W4313488798 cites W2892679831 @default.
• W4313488798 cites W2894871764 @default.
• W4313488798 cites W2903347362 @default.
• W4313488798 cites W2940408580 @default.
• W4313488798 cites W2949096170 @default.
• W4313488798 cites W2958211769 @default.
• W4313488798 cites W2973862493 @default.
• W4313488798 cites W2978742879 @default.
• W4313488798 cites W3005968613 @default.
• W4313488798 cites W3007341353 @default.
• W4313488798 cites W3010270404 @default.
• W4313488798 cites W3013683123 @default.
• W4313488798 cites W3034156734 @default.
• W4313488798 cites W3035259866 @default.
• W4313488798 cites W3036319615 @default.
• W4313488798 cites W3090034530 @default.
• W4313488798 cites W3123252891 @default.
• W4313488798 cites W3159245254 @default.
• W4313488798 cites W4206154257 @default.
• W4313488798 cites W4220722231 @default.
• W4313488798 cites W4230932396 @default.
• W4313488798 cites W4254111046 @default.
• W4313488798 cites W2762576037 @default.
• W4313488798 doi "https://doi.org/10.1128/spectrum.03509-22" @default.
• W4313488798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36598279" @default.

• next