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- W4313488819 abstract "The human immunodeficiency virus type 1 (HIV-1) is an intracellular pathogen whose replication cycle strictly depends on the host cell molecular machinery. HIV-1 crosses twice the plasma membrane, to get in and to get out of the cell. Therefore, the first and the last line of intracellular component encountered by the virus is the cortical actin network. Here, we review the role of actin and actin-related proteins in HIV-1 entry, assembly, budding, and release. We first highlight the mechanisms controlling actin polymerization at the entry site that promote the clustering of HIV-1 receptors, a crucial step for the virus to fuse with the plasma membrane. Then, we describe how actin is transiently depolymerized locally to allow the capsid to cross the actin cortex, before migrating towards the nucleus. Finally, we review the role of several actin-binding proteins in actin remodeling events required for membrane deformation and curvature at the viral assembly site as well as for virus release. Strikingly, it appears that common actin-regulating pathways are involved in viral entry and exit. However, while the role of actin remodeling during entry is well understood, this is not the case during exit. We discuss remaining challenges regarding the actin-dependent mechanisms involved in HIV-1 entry and exit, and how they could be overcome." @default.
- W4313488819 created "2023-01-06" @default.
- W4313488819 creator A5023995745 @default.
- W4313488819 creator A5047282448 @default.
- W4313488819 creator A5065530206 @default.
- W4313488819 date "2023-02-15" @default.
- W4313488819 modified "2023-10-17" @default.
- W4313488819 title "Get in and get out: Remodeling of the cellular actin cytoskeleton upon HIV‐1 infection" @default.
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