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- W4313488829 abstract "Peniandranoids A–E (1–5), five new meroterpenoids, together with three known analogues (6–8), were isolated from the fermentation of a soil-derived fungus, Penicillium sp.sb62. Their structures including absolute configurations were determined by extensive spectroscopic analysis, and the absolute configurations of compounds 1 and 5 were further elucidated by single-crystal X-ray diffraction. Peniandranoids A–E belong to a rare class of andrastin-type meroterpenoids incorporating an extra polyketide unit (a C10 polyketide unit for 1 and 2, a C9 polyketide unit for 3 and 4, and a furancarboxylic acid unit for 5). Compounds 1 and 6 exhibited favorable inhibitory activities against influenza virus A (H1N1) with EC50 values of 19 and 14 μg/mL, respectively. Compounds 3–8 exhibited potent immunosuppressive activities against concanavalin A-induced T cell proliferation with EC50 values ranging from 4.3 to 27 μM and lipopolysaccharide-induced B cell proliferation with EC50 values ranging from 7.5 to 23 μM, respectively." @default.
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- W4313488829 date "2023-01-03" @default.
- W4313488829 modified "2023-10-17" @default.
- W4313488829 title "Peniandranoids A–E: Meroterpenoids with Antiviral and Immunosuppressive Activity from a <i>Penicillium</i> sp." @default.
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- W4313488829 doi "https://doi.org/10.1021/acs.jnatprod.2c00766" @default.
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