Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313489034> ?p ?o ?g. }
- W4313489034 endingPage "11" @default.
- W4313489034 startingPage "1" @default.
- W4313489034 abstract "The cause of Alzheimer's disease (AD), and the pathophysiological mechanisms involved, remain major unanswered questions in medical science. Oral bacteria, especially those species associated with chronic periodontitis and particularly Porphyromonas gingivalis, are being linked causally to AD pathophysiology in a subpopulation of susceptible individuals. P. gingivalis produces large amounts of proteolytic enzymes, haem and iron capture proteins, adhesins and internalins that are secreted and attached to the cell surface and concentrated onto outer membrane vesicles (OMVs). These enzymes and adhesive proteins have been shown to cause host tissue damage and stimulate inflammatory responses. The ecological and pathophysiological roles of P. gingivalis OMVs, their ability to disperse widely throughout the host and deliver functional proteins lead to the proposal that they may be the link between a P. gingivalis focal infection in the subgingivae during periodontitis and neurodegeneration in AD. P. gingivalis OMVs can cross the blood brain barrier and may accelerate AD-specific neuropathology by increasing neuroinflammation, plaque/tangle formation and dysregulation of iron homeostasis, thereby inducing ferroptosis leading to neuronal death and neurodegeneration." @default.
- W4313489034 created "2023-01-06" @default.
- W4313489034 creator A5005897817 @default.
- W4313489034 creator A5006579378 @default.
- W4313489034 creator A5018022715 @default.
- W4313489034 creator A5045261132 @default.
- W4313489034 creator A5048673467 @default.
- W4313489034 date "2023-01-04" @default.
- W4313489034 modified "2023-10-18" @default.
- W4313489034 title "<i>Porphyromonas gingivalis</i> and the pathogenesis of Alzheimer’s disease" @default.
- W4313489034 cites W1508289240 @default.
- W4313489034 cites W1800567007 @default.
- W4313489034 cites W1804731458 @default.
- W4313489034 cites W1805754105 @default.
- W4313489034 cites W1895718854 @default.
- W4313489034 cites W1897291768 @default.
- W4313489034 cites W1946221762 @default.
- W4313489034 cites W1969061171 @default.
- W4313489034 cites W1977824944 @default.
- W4313489034 cites W1984388300 @default.
- W4313489034 cites W1993426964 @default.
- W4313489034 cites W1997183854 @default.
- W4313489034 cites W2013392940 @default.
- W4313489034 cites W2040370662 @default.
- W4313489034 cites W2049057420 @default.
- W4313489034 cites W2054325717 @default.
- W4313489034 cites W2054366592 @default.
- W4313489034 cites W2074150122 @default.
- W4313489034 cites W2074187917 @default.
- W4313489034 cites W2082722053 @default.
- W4313489034 cites W2086953830 @default.
- W4313489034 cites W2088210948 @default.
- W4313489034 cites W2090671384 @default.
- W4313489034 cites W2096158347 @default.
- W4313489034 cites W2127683899 @default.
- W4313489034 cites W2129218043 @default.
- W4313489034 cites W2133993854 @default.
- W4313489034 cites W2134437077 @default.
- W4313489034 cites W2134711807 @default.
- W4313489034 cites W2135686321 @default.
- W4313489034 cites W2136646476 @default.
- W4313489034 cites W2145305106 @default.
- W4313489034 cites W2146766390 @default.
- W4313489034 cites W2148435973 @default.
- W4313489034 cites W2150025846 @default.
- W4313489034 cites W2151292085 @default.
- W4313489034 cites W2172864295 @default.
- W4313489034 cites W2214404521 @default.
- W4313489034 cites W2314634699 @default.
- W4313489034 cites W2316646952 @default.
- W4313489034 cites W2317868549 @default.
- W4313489034 cites W2508296626 @default.
- W4313489034 cites W2621695716 @default.
- W4313489034 cites W2626365750 @default.
- W4313489034 cites W2738537980 @default.
- W4313489034 cites W2745288128 @default.
- W4313489034 cites W2754852214 @default.
- W4313489034 cites W2765303421 @default.
- W4313489034 cites W2768227814 @default.
- W4313489034 cites W2781955495 @default.
- W4313489034 cites W2803109272 @default.
- W4313489034 cites W2805001896 @default.
- W4313489034 cites W2805321653 @default.
- W4313489034 cites W2890601231 @default.
- W4313489034 cites W2895374072 @default.
- W4313489034 cites W2898757824 @default.
- W4313489034 cites W2912555658 @default.
- W4313489034 cites W2935572667 @default.
- W4313489034 cites W2965947914 @default.
- W4313489034 cites W2976719148 @default.
- W4313489034 cites W2980472864 @default.
- W4313489034 cites W2999725630 @default.
- W4313489034 cites W3014529666 @default.
- W4313489034 cites W3015489480 @default.
- W4313489034 cites W3021999147 @default.
- W4313489034 cites W3033688815 @default.
- W4313489034 cites W3034049776 @default.
- W4313489034 cites W3036873436 @default.
- W4313489034 cites W3039737183 @default.
- W4313489034 cites W3045530442 @default.
- W4313489034 cites W3081051521 @default.
- W4313489034 cites W3083830205 @default.
- W4313489034 cites W3100416080 @default.
- W4313489034 cites W3109783177 @default.
- W4313489034 cites W3116047515 @default.
- W4313489034 cites W3122909401 @default.
- W4313489034 cites W3138436947 @default.
- W4313489034 cites W3170872197 @default.
- W4313489034 cites W3174077129 @default.
- W4313489034 cites W3194772670 @default.
- W4313489034 cites W3199463220 @default.
- W4313489034 cites W4200213361 @default.
- W4313489034 cites W4306918395 @default.
- W4313489034 cites W864036077 @default.
- W4313489034 doi "https://doi.org/10.1080/1040841x.2022.2163613" @default.
- W4313489034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36597758" @default.
- W4313489034 hasPublicationYear "2023" @default.
- W4313489034 type Work @default.