Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313489037> ?p ?o ?g. }
- W4313489037 endingPage "8" @default.
- W4313489037 startingPage "1" @default.
- W4313489037 abstract "1. The extracellular matrix (ECM) constitutes the basal lamina and the area between follicular cells. Remodelling the ECM is believed to be a key event in follicular development, especially during selection, and plays an important role in cell migration, survival, and steroidogenesis. miR-199-3p is differentially expressed in the goose granulosa layer during follicular selection and is reported to play a primary role in inhibiting cell migration and invasion. Nevertheless, the effect of miR-199-3p on ovarian follicles and its role in follicular cellular migration is not understood.2. In this study, qRT-PCR assays revealed that miR-199-3p was differentially expressed in the granulosa layer from goose ovarian follicles before and after follicular selection. Additionally, miR-199-3p overexpression in cultured granulosa cells (GCs) from goose pre-hierarchical follicles significantly suppressed cell viability and migration. It elevated the concentration of progesterone and the expression of key progesterone production genes. Furthermore, miR-199-3p overexpression in the GCs of goose pre-hierarchical follicles inhibited the expression of ECM-related genes (ITGB8, MMP9 and MMP15) yet promoted the expression of another two ECM-related genes (COL4A1 and LAMA1). Finally, dual-fluorescence reporter experiments on 293T cells established the direct targeting of ECM gene ITGB8 by miR-199-3p.3. In conclusion, miR-199-3p may participate in granulosa cell migration, viability, and steroidogenesis in goose ovarian follicles before selection by modulating ITGB8 and other ECM-related genes." @default.
- W4313489037 created "2023-01-06" @default.
- W4313489037 creator A5012677271 @default.
- W4313489037 creator A5018346512 @default.
- W4313489037 creator A5026224115 @default.
- W4313489037 creator A5049906474 @default.
- W4313489037 creator A5052796762 @default.
- W4313489037 creator A5053745485 @default.
- W4313489037 creator A5075080019 @default.
- W4313489037 creator A5078281556 @default.
- W4313489037 date "2023-02-15" @default.
- W4313489037 modified "2023-09-26" @default.
- W4313489037 title "miR-199-3p suppresses cellular migration and viability and promotes progesterone production in goose ovarian follicles before selection through regulating <i>ITGB8</i> and other ECM-related genes" @default.
- W4313489037 cites W1975593847 @default.
- W4313489037 cites W1990082011 @default.
- W4313489037 cites W1993317008 @default.
- W4313489037 cites W2014639797 @default.
- W4313489037 cites W2020880417 @default.
- W4313489037 cites W2030406469 @default.
- W4313489037 cites W2032416845 @default.
- W4313489037 cites W2034877305 @default.
- W4313489037 cites W2044170628 @default.
- W4313489037 cites W2057811806 @default.
- W4313489037 cites W2098260977 @default.
- W4313489037 cites W2107277218 @default.
- W4313489037 cites W2113705043 @default.
- W4313489037 cites W2115062156 @default.
- W4313489037 cites W2122851311 @default.
- W4313489037 cites W2124744713 @default.
- W4313489037 cites W2130011061 @default.
- W4313489037 cites W2163041776 @default.
- W4313489037 cites W2589821153 @default.
- W4313489037 cites W2599889833 @default.
- W4313489037 cites W2603022558 @default.
- W4313489037 cites W2603864222 @default.
- W4313489037 cites W2625989536 @default.
- W4313489037 cites W2790100887 @default.
- W4313489037 cites W2790856977 @default.
- W4313489037 cites W2790898945 @default.
- W4313489037 cites W2900623784 @default.
- W4313489037 cites W2901185460 @default.
- W4313489037 cites W2911665670 @default.
- W4313489037 cites W2946645625 @default.
- W4313489037 cites W2977298191 @default.
- W4313489037 cites W2981968501 @default.
- W4313489037 cites W2989633385 @default.
- W4313489037 cites W3005333445 @default.
- W4313489037 cites W3109239418 @default.
- W4313489037 cites W3135821062 @default.
- W4313489037 cites W3189920043 @default.
- W4313489037 doi "https://doi.org/10.1080/00071668.2022.2159788" @default.
- W4313489037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36598846" @default.
- W4313489037 hasPublicationYear "2023" @default.
- W4313489037 type Work @default.
- W4313489037 citedByCount "0" @default.
- W4313489037 crossrefType "journal-article" @default.
- W4313489037 hasAuthorship W4313489037A5012677271 @default.
- W4313489037 hasAuthorship W4313489037A5018346512 @default.
- W4313489037 hasAuthorship W4313489037A5026224115 @default.
- W4313489037 hasAuthorship W4313489037A5049906474 @default.
- W4313489037 hasAuthorship W4313489037A5052796762 @default.
- W4313489037 hasAuthorship W4313489037A5053745485 @default.
- W4313489037 hasAuthorship W4313489037A5075080019 @default.
- W4313489037 hasAuthorship W4313489037A5078281556 @default.
- W4313489037 hasConcept C104317684 @default.
- W4313489037 hasConcept C127561419 @default.
- W4313489037 hasConcept C134018914 @default.
- W4313489037 hasConcept C1491633281 @default.
- W4313489037 hasConcept C150194340 @default.
- W4313489037 hasConcept C161733203 @default.
- W4313489037 hasConcept C187785154 @default.
- W4313489037 hasConcept C189165786 @default.
- W4313489037 hasConcept C2775997469 @default.
- W4313489037 hasConcept C2777203538 @default.
- W4313489037 hasConcept C2780536345 @default.
- W4313489037 hasConcept C53227056 @default.
- W4313489037 hasConcept C54355233 @default.
- W4313489037 hasConcept C86803240 @default.
- W4313489037 hasConcept C95444343 @default.
- W4313489037 hasConceptScore W4313489037C104317684 @default.
- W4313489037 hasConceptScore W4313489037C127561419 @default.
- W4313489037 hasConceptScore W4313489037C134018914 @default.
- W4313489037 hasConceptScore W4313489037C1491633281 @default.
- W4313489037 hasConceptScore W4313489037C150194340 @default.
- W4313489037 hasConceptScore W4313489037C161733203 @default.
- W4313489037 hasConceptScore W4313489037C187785154 @default.
- W4313489037 hasConceptScore W4313489037C189165786 @default.
- W4313489037 hasConceptScore W4313489037C2775997469 @default.
- W4313489037 hasConceptScore W4313489037C2777203538 @default.
- W4313489037 hasConceptScore W4313489037C2780536345 @default.
- W4313489037 hasConceptScore W4313489037C53227056 @default.
- W4313489037 hasConceptScore W4313489037C54355233 @default.
- W4313489037 hasConceptScore W4313489037C86803240 @default.
- W4313489037 hasConceptScore W4313489037C95444343 @default.
- W4313489037 hasLocation W43134890371 @default.
- W4313489037 hasLocation W43134890372 @default.
- W4313489037 hasOpenAccess W4313489037 @default.
- W4313489037 hasPrimaryLocation W43134890371 @default.