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- W4313489042 abstract "Septic arthritis is a joint disease caused by Staphylococcus aureus. Different macrophage populations contribute in various ways to control blood-borne infections and induce inflammatory responses. Macrophage tissue-resident niche is necessary for the suppression of chronic inflammation and may contribute to the pathogenesis of septic arthritis. Thus, to obtain a resolution of the disease and restoration of synovial homeostasis, it needs the activation of macrophages that further regulate the inflammatory consequences. The aim of this study was to find out the mechanism by which neutralization of transforming growth factor-beta (TGF-β) and/or interleukin (IL)-6 after induction of septic arthritis could alter the specific macrophage responses in spleen and synovial joints via different cytokines (osteoprotegerin (OPG), osteopontin (OPN), IL-10, IL-12 and CXCL8) cross-talking, and how the response could be modulated by reactive oxygen species vs antioxidant enzyme activities. Dual neutralization of TGF-β and IL-6 is notably effective in eliciting splenic and synovial tissue-resident macrophage responses. Synovial macrophage-derived IL-10 can elicit protection against septic arthritis via regulating receptor-activated nuclear factor Kappa-B ligand (RANKL)/OPG interaction. They also reduced oxidative stress by increasing the activity of antioxidant enzymes including SOD and catalase. Histopathological analysis revealed that dual neutralization of TGF-β and IL-6 prevented bone destruction and osteoclastic activity in septic arthritis by promoting the differential functional response of the splenic and synovial macrophages. Additionally, the macrophage-derived IL-10 can elicit protection against S. aureus-induced septic arthritis via regulating RANKL/OPG interaction. Further studies on STAT3 and STAT4 are needed for the understanding of such cross-talking in resident macrophages of arthritic mice." @default.
- W4313489042 created "2023-01-06" @default.
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- W4313489042 creator A5022196586 @default.
- W4313489042 creator A5031957747 @default.
- W4313489042 creator A5085095180 @default.
- W4313489042 date "2023-01-10" @default.
- W4313489042 modified "2023-10-02" @default.
- W4313489042 title "Simultaneous neutralization of <scp>TGF</scp>‐β and <scp>IL</scp>‐6 attenuates <i>Staphylococcus aureus</i>‐induced arthritic inflammation through differential modulation of splenic and synovial macrophages" @default.
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- W4313489042 doi "https://doi.org/10.1111/sji.13252" @default.
- W4313489042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36597222" @default.
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