FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313489073> ?p ?o ?g. }

• W4313489073 abstract "Duck plague virus (DPV) is a high-morbidity fowl alphaherpesvirus that causes septicemic lesions in various organs. Most DPV genes are conserved among herpesviruses, while a few are specific to fowl herpesviruses, including the LORF3 gene, for which there is currently no literature describing its biological properties and functions. This study first addressed whether the LORF3 protein is expressed by making specific polyclonal antibodies. We could demonstrate that DPV LORF3 is an early gene and encodes a protein involved in virion assembly, mainly localized in the nucleus of DPV-infected DEF cells. To investigate the role of this novel LORF3 protein in DPV pathogenesis, we generated a recombinant virus that lacks expression of the LORF3 protein. Our data revealed that the LORF3 protein is not essential for viral replication but contributes to DPV replication in vitro and in vivo and promotes duck plague disease morbidity and mortality. Interestingly, deletion of the LORF3 protein abolished thymus atrophy in DPV-vaccinated ducks. In conclusion, this study revealed the expression of avian herpesviruses-specific genes and unraveled the role of the early protein LORF3 in the pathogenesis of DPV. IMPORTANCE DPV is a highly lethal alphaherpesvirus that causes duck plague in birds of the order Anseriformes. The virus has caused huge economic losses to the poultry industry due to high morbidity and mortality and the cost of vaccination. DPV encodes 78 open reading frames (ORFs), and these genes are involved in various processes of the viral life cycle. Functional characterization of DPV genes is important for understanding the complex viral life cycle and DPV pathogenesis. Here, we identified a novel protein encoded by LORF3, and our data suggest that the LORF3 protein is involved in the occurrence and development of duck plague." @default.
• W4313489073 created "2023-01-06" @default.
• W4313489073 creator A5000460901 @default.
• W4313489073 creator A5007648400 @default.
• W4313489073 creator A5010409371 @default.
• W4313489073 creator A5013741739 @default.
• W4313489073 creator A5017902690 @default.
• W4313489073 creator A5019205025 @default.
• W4313489073 creator A5021517739 @default.
• W4313489073 creator A5028136131 @default.
• W4313489073 creator A5035312767 @default.
• W4313489073 creator A5039291898 @default.
• W4313489073 creator A5045418032 @default.
• W4313489073 creator A5049672306 @default.
• W4313489073 creator A5051671094 @default.
• W4313489073 creator A5064308879 @default.
• W4313489073 creator A5072909687 @default.
• W4313489073 creator A5075014478 @default.
• W4313489073 creator A5076699095 @default.
• W4313489073 creator A5076996063 @default.
• W4313489073 creator A5081902040 @default.
• W4313489073 creator A5083228843 @default.
• W4313489073 creator A5086086173 @default.
• W4313489073 creator A5088124858 @default.
• W4313489073 date "2023-01-31" @default.
• W4313489073 modified "2023-10-14" @default.
• W4313489073 title "Characterization of a Unique Novel LORF3 Protein of Duck Plague Virus and Its Potential Pathogenesis" @default.
• W4313489073 cites W1914632942 @default.
• W4313489073 cites W1967907506 @default.
• W4313489073 cites W1979698677 @default.
• W4313489073 cites W1979817387 @default.
• W4313489073 cites W1986299128 @default.
• W4313489073 cites W2002393523 @default.
• W4313489073 cites W2026604862 @default.
• W4313489073 cites W2040501853 @default.
• W4313489073 cites W2075048680 @default.
• W4313489073 cites W2079761535 @default.
• W4313489073 cites W2109739804 @default.
• W4313489073 cites W2113058731 @default.
• W4313489073 cites W2125290827 @default.
• W4313489073 cites W2125451710 @default.
• W4313489073 cites W2137720225 @default.
• W4313489073 cites W2147456352 @default.
• W4313489073 cites W2160268840 @default.
• W4313489073 cites W2161762799 @default.
• W4313489073 cites W2170461079 @default.
• W4313489073 cites W2215593807 @default.
• W4313489073 cites W2440390059 @default.
• W4313489073 cites W2578206074 @default.
• W4313489073 cites W2589576581 @default.
• W4313489073 cites W2600041157 @default.
• W4313489073 cites W2607014872 @default.
• W4313489073 cites W2755127639 @default.
• W4313489073 cites W2782729461 @default.
• W4313489073 cites W2785153058 @default.
• W4313489073 cites W2794292500 @default.
• W4313489073 cites W2794616879 @default.
• W4313489073 cites W2897661836 @default.
• W4313489073 cites W2921870141 @default.
• W4313489073 cites W2954755198 @default.
• W4313489073 cites W2954873408 @default.
• W4313489073 cites W3000611223 @default.
• W4313489073 cites W3019262622 @default.
• W4313489073 cites W3034984136 @default.
• W4313489073 cites W3086014788 @default.
• W4313489073 cites W3104012312 @default.
• W4313489073 cites W3117641399 @default.
• W4313489073 cites W3215028575 @default.
• W4313489073 cites W4206666007 @default.
• W4313489073 cites W4223452924 @default.
• W4313489073 cites W4224233429 @default.
• W4313489073 cites W4236722384 @default.
• W4313489073 doi "https://doi.org/10.1128/jvi.01577-22" @default.
• W4313489073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36598202" @default.
• W4313489073 hasPublicationYear "2023" @default.
• W4313489073 type Work @default.
• W4313489073 citedByCount "2" @default.
• W4313489073 countsByYear W43134890732023 @default.
• W4313489073 crossrefType "journal-article" @default.
• W4313489073 hasAuthorship W4313489073A5000460901 @default.
• W4313489073 hasAuthorship W4313489073A5007648400 @default.
• W4313489073 hasAuthorship W4313489073A5010409371 @default.
• W4313489073 hasAuthorship W4313489073A5013741739 @default.
• W4313489073 hasAuthorship W4313489073A5017902690 @default.
• W4313489073 hasAuthorship W4313489073A5019205025 @default.
• W4313489073 hasAuthorship W4313489073A5021517739 @default.
• W4313489073 hasAuthorship W4313489073A5028136131 @default.
• W4313489073 hasAuthorship W4313489073A5035312767 @default.
• W4313489073 hasAuthorship W4313489073A5039291898 @default.
• W4313489073 hasAuthorship W4313489073A5045418032 @default.
• W4313489073 hasAuthorship W4313489073A5049672306 @default.
• W4313489073 hasAuthorship W4313489073A5051671094 @default.
• W4313489073 hasAuthorship W4313489073A5064308879 @default.
• W4313489073 hasAuthorship W4313489073A5072909687 @default.
• W4313489073 hasAuthorship W4313489073A5075014478 @default.
• W4313489073 hasAuthorship W4313489073A5076699095 @default.
• W4313489073 hasAuthorship W4313489073A5076996063 @default.
• W4313489073 hasAuthorship W4313489073A5081902040 @default.
• W4313489073 hasAuthorship W4313489073A5083228843 @default.
• W4313489073 hasAuthorship W4313489073A5086086173 @default.

• next