FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313489075> ?p ?o ?g. }

• W4313489075 endingPage "15" @default.
• W4313489075 startingPage "1" @default.
• W4313489075 abstract "Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family. It plays a significant role in the regulation of brain metabolic activity, modification of synaptic efficacy, and enhances neuronal survival. A common naturally occurring allelic variation, i.e. G196A (Val66 Met, rs6265) of the BDNF gene is implicated in neuroplasticity. This study analyzes its expression levels and determines the frequency of BDNF G196A gene polymorphism in women with Turner syndrome (TS) compared to the controls. This case–control study comprised 14 TS patients and 8 healthy individuals. The expression levels of BDNF gene in TS patients were checked by qPCR. For BDNF gene, a dynamic expression range along with the presence of G196A polymorphism was found across all TS patients. The effects of Val66 Met mutation on BDNF protein structure and function were studied by molecular dynamics simulations of wild and mutant (Val66 Met) forms. The analysis of different trajectories generated by simulation showed that there was a significant change in the protein structure due to Val66 Met polymorphism, which might lead to functional impairment. This is first time we are reporting the association of BDNF G196A gene polymorphism with TS risk. Our study suggests that in turner patients, BDNF G196A polymorphism may be an important genetic factor predisposing to neuroplasticity risk and can be exploited as diagnostic/prognostic marker for TS. Further study on a large number of TS samples will prove this point beyond doubts or otherwise enriching the much desired repertoire of personalized medicine." @default.
• W4313489075 created "2023-01-06" @default.
• W4313489075 creator A5019444818 @default.
• W4313489075 creator A5019529064 @default.
• W4313489075 creator A5021877247 @default.
• W4313489075 creator A5027913973 @default.
• W4313489075 creator A5038555026 @default.
• W4313489075 creator A5053008837 @default.
• W4313489075 creator A5067380119 @default.
• W4313489075 creator A5078036000 @default.
• W4313489075 creator A5088906706 @default.
• W4313489075 date "2023-01-03" @default.
• W4313489075 modified "2023-09-30" @default.
• W4313489075 title "Brain-derived neurotrophic factor G196A (rs6265) gene polymorphism increases Turner syndrome susceptibility" @default.
• W4313489075 cites W1031578623 @default.
• W4313489075 cites W1484497860 @default.
• W4313489075 cites W1925793145 @default.
• W4313489075 cites W1963488745 @default.
• W4313489075 cites W1974476511 @default.
• W4313489075 cites W1994778680 @default.
• W4313489075 cites W1994958608 @default.
• W4313489075 cites W2008848928 @default.
• W4313489075 cites W2009775232 @default.
• W4313489075 cites W2013373204 @default.
• W4313489075 cites W2021733324 @default.
• W4313489075 cites W2045676051 @default.
• W4313489075 cites W2054668663 @default.
• W4313489075 cites W2067712274 @default.
• W4313489075 cites W2086103057 @default.
• W4313489075 cites W2086299876 @default.
• W4313489075 cites W2092511209 @default.
• W4313489075 cites W2096192426 @default.
• W4313489075 cites W2107277218 @default.
• W4313489075 cites W2130417276 @default.
• W4313489075 cites W2134231018 @default.
• W4313489075 cites W2402691253 @default.
• W4313489075 cites W2529157179 @default.
• W4313489075 cites W2593924056 @default.
• W4313489075 cites W2744868410 @default.
• W4313489075 cites W2809904006 @default.
• W4313489075 cites W2950435009 @default.
• W4313489075 cites W2957177175 @default.
• W4313489075 cites W3016448445 @default.
• W4313489075 cites W3177828909 @default.
• W4313489075 cites W4210970486 @default.
• W4313489075 doi "https://doi.org/10.1080/02648725.2022.2164417" @default.
• W4313489075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36597258" @default.
• W4313489075 hasPublicationYear "2023" @default.
• W4313489075 type Work @default.
• W4313489075 citedByCount "0" @default.
• W4313489075 crossrefType "journal-article" @default.
• W4313489075 hasAuthorship W4313489075A5019444818 @default.
• W4313489075 hasAuthorship W4313489075A5019529064 @default.
• W4313489075 hasAuthorship W4313489075A5021877247 @default.
• W4313489075 hasAuthorship W4313489075A5027913973 @default.
• W4313489075 hasAuthorship W4313489075A5038555026 @default.
• W4313489075 hasAuthorship W4313489075A5053008837 @default.
• W4313489075 hasAuthorship W4313489075A5067380119 @default.
• W4313489075 hasAuthorship W4313489075A5078036000 @default.
• W4313489075 hasAuthorship W4313489075A5088906706 @default.
• W4313489075 hasConcept C104317684 @default.
• W4313489075 hasConcept C126322002 @default.
• W4313489075 hasConcept C134018914 @default.
• W4313489075 hasConcept C149737253 @default.
• W4313489075 hasConcept C160539049 @default.
• W4313489075 hasConcept C170493617 @default.
• W4313489075 hasConcept C180754005 @default.
• W4313489075 hasConcept C2778163459 @default.
• W4313489075 hasConcept C2778790584 @default.
• W4313489075 hasConcept C54355233 @default.
• W4313489075 hasConcept C71924100 @default.
• W4313489075 hasConcept C86803240 @default.
• W4313489075 hasConceptScore W4313489075C104317684 @default.
• W4313489075 hasConceptScore W4313489075C126322002 @default.
• W4313489075 hasConceptScore W4313489075C134018914 @default.
• W4313489075 hasConceptScore W4313489075C149737253 @default.
• W4313489075 hasConceptScore W4313489075C160539049 @default.
• W4313489075 hasConceptScore W4313489075C170493617 @default.
• W4313489075 hasConceptScore W4313489075C180754005 @default.
• W4313489075 hasConceptScore W4313489075C2778163459 @default.
• W4313489075 hasConceptScore W4313489075C2778790584 @default.
• W4313489075 hasConceptScore W4313489075C54355233 @default.
• W4313489075 hasConceptScore W4313489075C71924100 @default.
• W4313489075 hasConceptScore W4313489075C86803240 @default.
• W4313489075 hasFunder F4320320720 @default.
• W4313489075 hasLocation W43134890751 @default.
• W4313489075 hasLocation W43134890752 @default.
• W4313489075 hasOpenAccess W4313489075 @default.
• W4313489075 hasPrimaryLocation W43134890751 @default.
• W4313489075 hasRelatedWork W1867987620 @default.
• W4313489075 hasRelatedWork W1972449685 @default.
• W4313489075 hasRelatedWork W1987406528 @default.
• W4313489075 hasRelatedWork W2057739827 @default.
• W4313489075 hasRelatedWork W2070922469 @default.
• W4313489075 hasRelatedWork W2086317124 @default.
• W4313489075 hasRelatedWork W2104295145 @default.
• W4313489075 hasRelatedWork W2160961970 @default.
• W4313489075 hasRelatedWork W2223919059 @default.

• next