FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313489188> ?p ?o ?g. }

• W4313489188 endingPage "346" @default.
• W4313489188 startingPage "337" @default.
• W4313489188 abstract "Chronic cannabis use is associated with impaired cognitive function. Evidence indicates cannabidiol (CBD) might be beneficial for treating cannabis use disorder. CBD may also have pro-cognitive effects; however, its effect on cognition in people with cannabis use disorder is currently unclear.We aimed to assess whether a 4-week CBD treatment impacted cognitive function. We hypothesised that CBD treatment would improve cognition from baseline to week 4, compared to placebo.Cognition was assessed as a secondary outcome in a phase 2a randomised, double-blind, parallel-group and placebo-controlled clinical trial of 4-week daily 200 mg, 400 mg and 800 mg CBD for the treatment of cannabis use disorder. Participants had moderate or severe DSM-5 cannabis use disorder and intended to quit cannabis use. Our pre-registered primary cognitive outcome was delayed prose recall. Secondary cognitive outcomes were immediate prose recall, stop signal reaction time, trail-making task performance, verbal fluency and digit span.Seventy participants were randomly assigned to placebo (n = 23), 400 mg CBD (n = 24) and 800 mg CBD (n = 23). A 200 mg group was eliminated from the trial because it was an inefficacious dose at interim analysis (n = 12) and was not analysed here. For the primary cognitive outcome, there was no effect of CBD compared to placebo, evidenced by a lack of dose-by-time interaction at 400 mg (0.46, 95%CIs: - 1.41, 2.54) and 800 mg (0.89, 95%CIs: - 0.99, 2.81). There was no effect of CBD compared to placebo on secondary cognitive outcomes, except backwards digit span which increased following 800 mg CBD (0.30, 95%CIs: 0.02, 0.58).In this clinical trial for cannabis use disorder, CBD did not influence delayed verbal memory. CBD did not have broad cognitive effects but 800 mg daily treatment may improve working memory manipulation.The trial was registered with ClinicalTrials.gov (NCT02044809) and the EU Clinical Trials Register (2013-000,361-36)." @default.
• W4313489188 created "2023-01-06" @default.
• W4313489188 creator A5006122683 @default.
• W4313489188 creator A5007843987 @default.
• W4313489188 creator A5014608136 @default.
• W4313489188 creator A5018031482 @default.
• W4313489188 creator A5023729638 @default.
• W4313489188 creator A5029492033 @default.
• W4313489188 creator A5058235132 @default.
• W4313489188 creator A5070721468 @default.
• W4313489188 creator A5073240173 @default.
• W4313489188 creator A5090852573 @default.
• W4313489188 date "2023-01-04" @default.
• W4313489188 modified "2023-10-14" @default.
• W4313489188 title "Effect of four-week cannabidiol treatment on cognitive function: secondary outcomes from a randomised clinical trial for the treatment of cannabis use disorder" @default.
• W4313489188 cites W1580703892 @default.
• W4313489188 cites W1973088286 @default.
• W4313489188 cites W1975352837 @default.
• W4313489188 cites W2006242135 @default.
• W4313489188 cites W2015441565 @default.
• W4313489188 cites W2044958137 @default.
• W4313489188 cites W2054333577 @default.
• W4313489188 cites W2075705425 @default.
• W4313489188 cites W2106231056 @default.
• W4313489188 cites W2195309282 @default.
• W4313489188 cites W2315745933 @default.
• W4313489188 cites W2772725445 @default.
• W4313489188 cites W2773406626 @default.
• W4313489188 cites W2793709084 @default.
• W4313489188 cites W2795424865 @default.
• W4313489188 cites W2890337129 @default.
• W4313489188 cites W2899112555 @default.
• W4313489188 cites W2924041720 @default.
• W4313489188 cites W2978817856 @default.
• W4313489188 cites W2985168220 @default.
• W4313489188 cites W3046002454 @default.
• W4313489188 cites W3047624740 @default.
• W4313489188 cites W3048366406 @default.
• W4313489188 cites W3087751893 @default.
• W4313489188 cites W3120251132 @default.
• W4313489188 cites W3198342021 @default.
• W4313489188 doi "https://doi.org/10.1007/s00213-022-06303-5" @default.
• W4313489188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36598543" @default.
• W4313489188 hasPublicationYear "2023" @default.
• W4313489188 type Work @default.
• W4313489188 citedByCount "0" @default.
• W4313489188 crossrefType "journal-article" @default.
• W4313489188 hasAuthorship W4313489188A5006122683 @default.
• W4313489188 hasAuthorship W4313489188A5007843987 @default.
• W4313489188 hasAuthorship W4313489188A5014608136 @default.
• W4313489188 hasAuthorship W4313489188A5018031482 @default.
• W4313489188 hasAuthorship W4313489188A5023729638 @default.
• W4313489188 hasAuthorship W4313489188A5029492033 @default.
• W4313489188 hasAuthorship W4313489188A5058235132 @default.
• W4313489188 hasAuthorship W4313489188A5070721468 @default.
• W4313489188 hasAuthorship W4313489188A5073240173 @default.
• W4313489188 hasAuthorship W4313489188A5090852573 @default.
• W4313489188 hasBestOaLocation W43134891881 @default.
• W4313489188 hasConcept C118552586 @default.
• W4313489188 hasConcept C126322002 @default.
• W4313489188 hasConcept C14216870 @default.
• W4313489188 hasConcept C142724271 @default.
• W4313489188 hasConcept C15744967 @default.
• W4313489188 hasConcept C168563851 @default.
• W4313489188 hasConcept C169900460 @default.
• W4313489188 hasConcept C204787440 @default.
• W4313489188 hasConcept C27081682 @default.
• W4313489188 hasConcept C2776895053 @default.
• W4313489188 hasConcept C2777056318 @default.
• W4313489188 hasConcept C71924100 @default.
• W4313489188 hasConcept C97530452 @default.
• W4313489188 hasConceptScore W4313489188C118552586 @default.
• W4313489188 hasConceptScore W4313489188C126322002 @default.
• W4313489188 hasConceptScore W4313489188C14216870 @default.
• W4313489188 hasConceptScore W4313489188C142724271 @default.
• W4313489188 hasConceptScore W4313489188C15744967 @default.
• W4313489188 hasConceptScore W4313489188C168563851 @default.
• W4313489188 hasConceptScore W4313489188C169900460 @default.
• W4313489188 hasConceptScore W4313489188C204787440 @default.
• W4313489188 hasConceptScore W4313489188C27081682 @default.
• W4313489188 hasConceptScore W4313489188C2776895053 @default.
• W4313489188 hasConceptScore W4313489188C2777056318 @default.
• W4313489188 hasConceptScore W4313489188C71924100 @default.
• W4313489188 hasConceptScore W4313489188C97530452 @default.
• W4313489188 hasFunder F4320334626 @default.
• W4313489188 hasIssue "2" @default.
• W4313489188 hasLocation W43134891881 @default.
• W4313489188 hasLocation W43134891882 @default.
• W4313489188 hasLocation W43134891883 @default.
• W4313489188 hasLocation W43134891884 @default.
• W4313489188 hasLocation W43134891885 @default.
• W4313489188 hasOpenAccess W4313489188 @default.
• W4313489188 hasPrimaryLocation W43134891881 @default.
• W4313489188 hasRelatedWork W2607560691 @default.
• W4313489188 hasRelatedWork W2766418163 @default.
• W4313489188 hasRelatedWork W2766462984 @default.
• W4313489188 hasRelatedWork W3105523296 @default.
• W4313489188 hasRelatedWork W3156357446 @default.

• next