FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313489600> ?p ?o ?g. }

• W4313489600 endingPage "505" @default.
• W4313489600 startingPage "493" @default.
• W4313489600 abstract "We report on the clinicopathologic features of 27 pleomorphic giant cell carcinoma (PGCC) cases of the prostate identified in 20 patients with an age range of 51 to 84 years (68 ± 9; median 71 years). Charlson comorbidity index ranged from 3 to 12. Serum PSA ranged from 4.30 to 662 ng/mL (median 13 ng/mL). On histologic examination, bizarre giant cells with pleomorphic nuclei characterized pleomorphic giant cell carcinoma of the prostate. PGCC component was present in 5% to 100%, with half of the patients presenting with ≥ 20%. Half of the patients initially presented with T4 and 26% with T3 disease. All patients were considered Gleason scores of 9 to 10 (ISUP grade 5). A combination of hormone therapy with chemotherapy with or without radiation therapy was applied in 68% of patients. On follow-up, 14 patients (52%) were alive with disease (1-69 months) or dead of disease (1-38 months). Patients diagnosed earlier with lower TNM stage had longer survival than those diagnosed at a later T-stage or with metastatic disease (p = 0.02). The percentage of PGCC was not related to survival in the current study. Molecular alterations in 3 samples showed a microsatellite-stable disease with low tumor mutation burden and variable PTEN, PTCH1, KDM6A, ARv7, and PIK3CA loss/alteration, TP53 mutation, TMPRSS2-ERG fusion, and MYC, PIK3CB, RICTOR, or IRS2 amplification. Our findings suggest that PGCC is a rare and aggressive subtype of prostate carcinoma whose recognition may steer clinicians to adopt more aggressive treatments and investigate new therapeutic strategies." @default.
• W4313489600 created "2023-01-06" @default.
• W4313489600 creator A5004296799 @default.
• W4313489600 creator A5025973467 @default.
• W4313489600 creator A5027474880 @default.
• W4313489600 creator A5030533194 @default.
• W4313489600 creator A5039758071 @default.
• W4313489600 creator A5056783674 @default.
• W4313489600 creator A5058161742 @default.
• W4313489600 creator A5089188957 @default.
• W4313489600 date "2023-01-05" @default.
• W4313489600 modified "2023-10-14" @default.
• W4313489600 title "Pleomorphic giant cell carcinoma of the prostate: clinicopathologic analysis and oncological outcomes" @default.
• W4313489600 cites W1590098473 @default.
• W4313489600 cites W2036763066 @default.
• W4313489600 cites W2049140983 @default.
• W4313489600 cites W2065273953 @default.
• W4313489600 cites W2066395486 @default.
• W4313489600 cites W2106315111 @default.
• W4313489600 cites W2137974207 @default.
• W4313489600 cites W2138160084 @default.
• W4313489600 cites W2148622489 @default.
• W4313489600 cites W2502134830 @default.
• W4313489600 cites W2571250257 @default.
• W4313489600 cites W2598884790 @default.
• W4313489600 cites W2611365525 @default.
• W4313489600 cites W2750109247 @default.
• W4313489600 cites W2790119669 @default.
• W4313489600 cites W2911195739 @default.
• W4313489600 cites W2915648514 @default.
• W4313489600 cites W2964673115 @default.
• W4313489600 cites W3005870288 @default.
• W4313489600 cites W3019083657 @default.
• W4313489600 cites W3041588796 @default.
• W4313489600 cites W3132184200 @default.
• W4313489600 cites W4250567874 @default.
• W4313489600 doi "https://doi.org/10.1007/s00428-022-03481-7" @default.
• W4313489600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36600115" @default.
• W4313489600 hasPublicationYear "2023" @default.
• W4313489600 type Work @default.
• W4313489600 citedByCount "1" @default.
• W4313489600 countsByYear W43134896002023 @default.
• W4313489600 crossrefType "journal-article" @default.
• W4313489600 hasAuthorship W4313489600A5004296799 @default.
• W4313489600 hasAuthorship W4313489600A5025973467 @default.
• W4313489600 hasAuthorship W4313489600A5027474880 @default.
• W4313489600 hasAuthorship W4313489600A5030533194 @default.
• W4313489600 hasAuthorship W4313489600A5039758071 @default.
• W4313489600 hasAuthorship W4313489600A5056783674 @default.
• W4313489600 hasAuthorship W4313489600A5058161742 @default.
• W4313489600 hasAuthorship W4313489600A5089188957 @default.
• W4313489600 hasBestOaLocation W43134896001 @default.
• W4313489600 hasConcept C121608353 @default.
• W4313489600 hasConcept C126322002 @default.
• W4313489600 hasConcept C142724271 @default.
• W4313489600 hasConcept C143998085 @default.
• W4313489600 hasConcept C146357865 @default.
• W4313489600 hasConcept C151730666 @default.
• W4313489600 hasConcept C2776235491 @default.
• W4313489600 hasConcept C2777546739 @default.
• W4313489600 hasConcept C509974204 @default.
• W4313489600 hasConcept C71924100 @default.
• W4313489600 hasConcept C77076574 @default.
• W4313489600 hasConcept C86803240 @default.
• W4313489600 hasConcept C90924648 @default.
• W4313489600 hasConceptScore W4313489600C121608353 @default.
• W4313489600 hasConceptScore W4313489600C126322002 @default.
• W4313489600 hasConceptScore W4313489600C142724271 @default.
• W4313489600 hasConceptScore W4313489600C143998085 @default.
• W4313489600 hasConceptScore W4313489600C146357865 @default.
• W4313489600 hasConceptScore W4313489600C151730666 @default.
• W4313489600 hasConceptScore W4313489600C2776235491 @default.
• W4313489600 hasConceptScore W4313489600C2777546739 @default.
• W4313489600 hasConceptScore W4313489600C509974204 @default.
• W4313489600 hasConceptScore W4313489600C71924100 @default.
• W4313489600 hasConceptScore W4313489600C77076574 @default.
• W4313489600 hasConceptScore W4313489600C86803240 @default.
• W4313489600 hasConceptScore W4313489600C90924648 @default.
• W4313489600 hasFunder F4320321579 @default.
• W4313489600 hasIssue "3" @default.
• W4313489600 hasLocation W43134896001 @default.
• W4313489600 hasLocation W43134896002 @default.
• W4313489600 hasLocation W43134896003 @default.
• W4313489600 hasOpenAccess W4313489600 @default.
• W4313489600 hasPrimaryLocation W43134896001 @default.
• W4313489600 hasRelatedWork W1966531936 @default.
• W4313489600 hasRelatedWork W2008450458 @default.
• W4313489600 hasRelatedWork W2038093082 @default.
• W4313489600 hasRelatedWork W2041171795 @default.
• W4313489600 hasRelatedWork W2080831921 @default.
• W4313489600 hasRelatedWork W2155941014 @default.
• W4313489600 hasRelatedWork W2356105190 @default.
• W4313489600 hasRelatedWork W2384708512 @default.
• W4313489600 hasRelatedWork W2388189771 @default.
• W4313489600 hasRelatedWork W2418695766 @default.
• W4313489600 hasVolume "482" @default.
• W4313489600 isParatext "false" @default.
• W4313489600 isRetracted "false" @default.

• next