FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313490214> ?p ?o ?g. }

• W4313490214 abstract "Caspases are evolutionarily conserved cysteinyl proteases that are integral in cell development and apoptosis. All apoptotic caspases evolved from a common ancestor into two distinct subfamilies with either monomeric (initiators) or dimeric (effectors) oligomeric states. The regulation of apoptosis is influenced by the activation mechanism of the two subfamilies, but the evolution of the well-conserved caspase-hemoglobinase fold into the two subfamilies is not well understood. We examined the folding landscape of monomeric caspases from two coral species over a broad pH range of 3 to 10.5. On an evolutionary timescale, the two coral caspases diverged from each other approximately 300 million years ago, and they diverged from human caspases about 600 million years ago. Our results indicate that both proteins have overall high stability, ∼ 15 kcal mol -1 near the physiological pH range (pH 6 to pH 8), and unfold via two partially folded intermediates, I 1 and I 2 , that are in equilibrium with the native and the unfolded state. Like the dimeric caspases, the monomeric coral caspases undergo a pH-dependent conformational change resulting from the titration of an evolutionarily conserved site. Data from molecular dynamics simulations paired with limited proteolysis and MALDI-TOF mass spectrometry show that the small subunit of the monomeric caspases is unstable and unfolds prior to the large subunit. Overall, the data suggest that all caspases share a conserved folding landscape, that a conserved allosteric site can be fine-tuned for species-specific regulation, and that the subfamily of stable dimers may have evolved to stabilize the small subunit." @default.
• W4313490214 created "2023-01-06" @default.
• W4313490214 creator A5023203056 @default.
• W4313490214 creator A5062321489 @default.
• W4313490214 date "2023-01-04" @default.
• W4313490214 modified "2023-09-27" @default.
• W4313490214 title "Sequential unfolding mechanisms of monomeric caspases" @default.
• W4313490214 cites W1031578623 @default.
• W4313490214 cites W11634938 @default.
• W4313490214 cites W1919860012 @default.
• W4313490214 cites W1965196431 @default.
• W4313490214 cites W1969331809 @default.
• W4313490214 cites W1976312800 @default.
• W4313490214 cites W1978675599 @default.
• W4313490214 cites W1991794210 @default.
• W4313490214 cites W1995943393 @default.
• W4313490214 cites W2000193215 @default.
• W4313490214 cites W2002061130 @default.
• W4313490214 cites W2005241888 @default.
• W4313490214 cites W2009374111 @default.
• W4313490214 cites W2010053288 @default.
• W4313490214 cites W2014983456 @default.
• W4313490214 cites W2014988811 @default.
• W4313490214 cites W2016540525 @default.
• W4313490214 cites W2020438797 @default.
• W4313490214 cites W202553697 @default.
• W4313490214 cites W2028046413 @default.
• W4313490214 cites W2031773989 @default.
• W4313490214 cites W2058856913 @default.
• W4313490214 cites W2067827857 @default.
• W4313490214 cites W2068574714 @default.
• W4313490214 cites W2070801759 @default.
• W4313490214 cites W2094012816 @default.
• W4313490214 cites W2100246815 @default.
• W4313490214 cites W2111647009 @default.
• W4313490214 cites W2117458899 @default.
• W4313490214 cites W2130060890 @default.
• W4313490214 cites W2133190342 @default.
• W4313490214 cites W2135682056 @default.
• W4313490214 cites W2148461722 @default.
• W4313490214 cites W2153290883 @default.
• W4313490214 cites W2166356964 @default.
• W4313490214 cites W2239536724 @default.
• W4313490214 cites W2510186658 @default.
• W4313490214 cites W2597195148 @default.
• W4313490214 cites W2600396554 @default.
• W4313490214 cites W2804822363 @default.
• W4313490214 cites W2886133886 @default.
• W4313490214 cites W2918063357 @default.
• W4313490214 cites W2983552614 @default.
• W4313490214 cites W3005318734 @default.
• W4313490214 cites W3048551549 @default.
• W4313490214 cites W3201956974 @default.
• W4313490214 cites W4281666337 @default.
• W4313490214 doi "https://doi.org/10.1101/2023.01.04.522771" @default.
• W4313490214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36711547" @default.
• W4313490214 hasPublicationYear "2023" @default.
• W4313490214 type Work @default.
• W4313490214 citedByCount "0" @default.
• W4313490214 crossrefType "posted-content" @default.
• W4313490214 hasAuthorship W4313490214A5023203056 @default.
• W4313490214 hasAuthorship W4313490214A5062321489 @default.
• W4313490214 hasBestOaLocation W43134902141 @default.
• W4313490214 hasConcept C104292427 @default.
• W4313490214 hasConcept C104317684 @default.
• W4313490214 hasConcept C163421366 @default.
• W4313490214 hasConcept C167625842 @default.
• W4313490214 hasConcept C185592680 @default.
• W4313490214 hasConcept C190283241 @default.
• W4313490214 hasConcept C199216141 @default.
• W4313490214 hasConcept C31573885 @default.
• W4313490214 hasConcept C33195913 @default.
• W4313490214 hasConcept C55493867 @default.
• W4313490214 hasConcept C86803240 @default.
• W4313490214 hasConcept C95444343 @default.
• W4313490214 hasConcept C98424977 @default.
• W4313490214 hasConceptScore W4313490214C104292427 @default.
• W4313490214 hasConceptScore W4313490214C104317684 @default.
• W4313490214 hasConceptScore W4313490214C163421366 @default.
• W4313490214 hasConceptScore W4313490214C167625842 @default.
• W4313490214 hasConceptScore W4313490214C185592680 @default.
• W4313490214 hasConceptScore W4313490214C190283241 @default.
• W4313490214 hasConceptScore W4313490214C199216141 @default.
• W4313490214 hasConceptScore W4313490214C31573885 @default.
• W4313490214 hasConceptScore W4313490214C33195913 @default.
• W4313490214 hasConceptScore W4313490214C55493867 @default.
• W4313490214 hasConceptScore W4313490214C86803240 @default.
• W4313490214 hasConceptScore W4313490214C95444343 @default.
• W4313490214 hasConceptScore W4313490214C98424977 @default.
• W4313490214 hasLocation W43134902141 @default.
• W4313490214 hasLocation W43134902142 @default.
• W4313490214 hasLocation W43134902143 @default.
• W4313490214 hasOpenAccess W4313490214 @default.
• W4313490214 hasPrimaryLocation W43134902141 @default.
• W4313490214 hasRelatedWork W1568506601 @default.
• W4313490214 hasRelatedWork W1967264415 @default.
• W4313490214 hasRelatedWork W1984268188 @default.
• W4313490214 hasRelatedWork W2001919785 @default.
• W4313490214 hasRelatedWork W2029107211 @default.
• W4313490214 hasRelatedWork W2048549823 @default.

• next