Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313490248> ?p ?o ?g. }
- W4313490248 abstract "Abstract There are no known approved pharmacotherapies for non‐alcoholic fatty liver disease (NAFLD) in the clinical setting. Although studies have provided substantial evidence that geranylgeranyl diphosphate synthase (GGPPS) is a potential therapeutic target for the treatment of NAFLD corresponding drug screening is rare. A GGPPS‐targeted inhibitor is identified using a structure‐based virtual small molecule screening method. The interaction of 4‐AZ and GGPPS is detected by microscale thermophoresis. 4‐AZ degradation of GGPPS by the ubiquitin‐proteasome pathway is detected by western blotting. The anti‐steatotic effect of 4‐AZ in vivo is detected by CT. Lipid‐related gene detection is detected by real‐time PCR both in primary hepatocytes and mice. The compound inhibits the accumulation of lipids in primary hepatocytes and decreases lipogenic gene expression through GGPPS. Pharmacological studies show that 4‐AZ can attenuate hepatic steatosis and improve liver injury in high‐fat diet‐induced mice. This data provides a novel application of 4‐AZ NAFLD therapy, proving that the inhibition of GGPPS is a novel strategy for the treatment of NAFLD." @default.
- W4313490248 created "2023-01-06" @default.
- W4313490248 creator A5004405673 @default.
- W4313490248 creator A5012182255 @default.
- W4313490248 creator A5015864983 @default.
- W4313490248 creator A5021388534 @default.
- W4313490248 creator A5021583927 @default.
- W4313490248 creator A5035894738 @default.
- W4313490248 creator A5040588043 @default.
- W4313490248 creator A5041061250 @default.
- W4313490248 creator A5041536834 @default.
- W4313490248 creator A5042080788 @default.
- W4313490248 creator A5044616652 @default.
- W4313490248 creator A5049692788 @default.
- W4313490248 creator A5050925267 @default.
- W4313490248 creator A5076479076 @default.
- W4313490248 creator A5078240233 @default.
- W4313490248 creator A5081379713 @default.
- W4313490248 creator A5089277479 @default.
- W4313490248 date "2023-01-04" @default.
- W4313490248 modified "2023-10-14" @default.
- W4313490248 title "Alleviation of Hepatic Steatosis by 4‐azidophlorizin via the Degradation of Geranylgeranyl Diphosphate Synthase by the Ubiquitin‐Proteasome Pathway in Vivo and in Vitro" @default.
- W4313490248 cites W1966922165 @default.
- W4313490248 cites W1972401702 @default.
- W4313490248 cites W1975295948 @default.
- W4313490248 cites W1992284130 @default.
- W4313490248 cites W2010316877 @default.
- W4313490248 cites W2018631536 @default.
- W4313490248 cites W2019265270 @default.
- W4313490248 cites W2036615743 @default.
- W4313490248 cites W2044874695 @default.
- W4313490248 cites W2128460332 @default.
- W4313490248 cites W2264072217 @default.
- W4313490248 cites W2364200298 @default.
- W4313490248 cites W2508708811 @default.
- W4313490248 cites W2747071866 @default.
- W4313490248 cites W2759997926 @default.
- W4313490248 cites W2808779488 @default.
- W4313490248 cites W2810423511 @default.
- W4313490248 cites W2811019994 @default.
- W4313490248 cites W2884528442 @default.
- W4313490248 cites W2891680487 @default.
- W4313490248 cites W2898998692 @default.
- W4313490248 cites W2923695679 @default.
- W4313490248 cites W2924788077 @default.
- W4313490248 cites W2994320390 @default.
- W4313490248 cites W2994671505 @default.
- W4313490248 cites W3004644667 @default.
- W4313490248 cites W3006306205 @default.
- W4313490248 cites W3009731211 @default.
- W4313490248 cites W3088075449 @default.
- W4313490248 cites W3126030429 @default.
- W4313490248 cites W3200461277 @default.
- W4313490248 cites W3207086349 @default.
- W4313490248 cites W4242397592 @default.
- W4313490248 doi "https://doi.org/10.1002/adbi.202200150" @default.
- W4313490248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36599632" @default.
- W4313490248 hasPublicationYear "2023" @default.
- W4313490248 type Work @default.
- W4313490248 citedByCount "0" @default.
- W4313490248 crossrefType "journal-article" @default.
- W4313490248 hasAuthorship W4313490248A5004405673 @default.
- W4313490248 hasAuthorship W4313490248A5012182255 @default.
- W4313490248 hasAuthorship W4313490248A5015864983 @default.
- W4313490248 hasAuthorship W4313490248A5021388534 @default.
- W4313490248 hasAuthorship W4313490248A5021583927 @default.
- W4313490248 hasAuthorship W4313490248A5035894738 @default.
- W4313490248 hasAuthorship W4313490248A5040588043 @default.
- W4313490248 hasAuthorship W4313490248A5041061250 @default.
- W4313490248 hasAuthorship W4313490248A5041536834 @default.
- W4313490248 hasAuthorship W4313490248A5042080788 @default.
- W4313490248 hasAuthorship W4313490248A5044616652 @default.
- W4313490248 hasAuthorship W4313490248A5049692788 @default.
- W4313490248 hasAuthorship W4313490248A5050925267 @default.
- W4313490248 hasAuthorship W4313490248A5076479076 @default.
- W4313490248 hasAuthorship W4313490248A5078240233 @default.
- W4313490248 hasAuthorship W4313490248A5081379713 @default.
- W4313490248 hasAuthorship W4313490248A5089277479 @default.
- W4313490248 hasConcept C126322002 @default.
- W4313490248 hasConcept C134018914 @default.
- W4313490248 hasConcept C150903083 @default.
- W4313490248 hasConcept C185592680 @default.
- W4313490248 hasConcept C207001950 @default.
- W4313490248 hasConcept C27740335 @default.
- W4313490248 hasConcept C2776175330 @default.
- W4313490248 hasConcept C2778772119 @default.
- W4313490248 hasConcept C2779134260 @default.
- W4313490248 hasConcept C4733338 @default.
- W4313490248 hasConcept C48289651 @default.
- W4313490248 hasConcept C55493867 @default.
- W4313490248 hasConcept C71924100 @default.
- W4313490248 hasConcept C86803240 @default.
- W4313490248 hasConcept C98274493 @default.
- W4313490248 hasConceptScore W4313490248C126322002 @default.
- W4313490248 hasConceptScore W4313490248C134018914 @default.
- W4313490248 hasConceptScore W4313490248C150903083 @default.
- W4313490248 hasConceptScore W4313490248C185592680 @default.
- W4313490248 hasConceptScore W4313490248C207001950 @default.
- W4313490248 hasConceptScore W4313490248C27740335 @default.
- W4313490248 hasConceptScore W4313490248C2776175330 @default.