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- W4313491161 abstract "Abstract This study was aimed to investigate the effects of p-coumaric acid (PCA), L-dopamine (L-DOPA), and combinations in the neuroblastoma (N1E-115) cell line. Administration of L-DOPA, L-DOPA + pCA caused oxidative stress in N1E-115 cells and it was determined that it caused oxidative stress by increasing 12.54 and 3.68-fold in Superoxide dismutase (SOD) gene, 11.49 and 4.83-fold increase in Catalase (CAT) gene, respectively. In L-DOPA and L-DOPA + pCA application, p21 gene expression was compared to control, respectively; It was observed that it increased 1.28 and 3.20-fold, and this increased change in p21 gene expression compared to the control suggests that the cell cycle stopped in the G1 phase in response to stress in the treatment groups. In the application of L-DOPA + pCA to N1E-115 cells, it was determined that the BCL-2 gene, which is an apoptosis inhibitor, was suppressed and the BAX gene increased 13.04 fold compared to the control. As a result; In the N1E-115 line, it was determined that the cytotoxic effect of L-DOPA + pCA application was less than the individual application of the substances, and it was determined that PCA had an inhibitory effect on dopamine-induced stress." @default.
- W4313491161 created "2023-01-06" @default.
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- W4313491161 date "2023-01-03" @default.
- W4313491161 modified "2023-09-25" @default.
- W4313491161 title "Effects of L-DOPA and PCA combination therapy on oxidative stress, DNA damage, mitochondrial apoptosis in neuroblastoma cells" @default.
- W4313491161 doi "https://doi.org/10.21203/rs.3.rs-2411858/v1" @default.
- W4313491161 hasPublicationYear "2023" @default.
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